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aminothiols exchange in coronavirus disease 2019

Frigid Zone Medicine 2023年第1期3卷 37-41页

作者： Fefelova Elena Viktorovna Karavaeva Tatyana Mikhailovna Parshina Anastasia Anatolyevna Ma Van De Vasilina Denisovna Tereshkov Pavel Petrovich Department of Pathological Physiology Chita State Medical AcademyChita 672090Russia Department of Chemistry and Biochemistry Chita State Medical AcademyChita 672090Russia Department of Faculty Therapy Chita State Medical AcademyChita 672090Russia Laboratory of Experimental and Clinical Biochemistry and Immunology Chita State Medical AcademyChita 672090Russia

Objective:Clinical manifestation of the inflammatory process in its relation to biochemical markers(total cysteine[Cys],cysteine-glycine[CysGly],glutathione[GSH],glutamate-cysteine[Glu-Cys],homocysteine[Hcy],the ratio of reduced to oxidized glutathione[GSH/GSSG],the ratio of reduced to oxidized cysteine[CySH/CySS],malondialdehyde-oxidized low-density lipoproteins[MDA-oxLDL])has been studied in patients with coronavirus disease 2019(COVID-19).Material and methods:48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our *** participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6(IL-6).Results:All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6(by 54.6%).There was no comorbidity in patients with mild COVID-19(nasopharyngitis symptoms)and in healthy control subjects.50%of patients with lung damage had accompanying *** of aminoethyl metabolism were detected in COVID-19 patients:as reflected by the decreased levels of Cys,CysGly,and Glu-Cys and the increased levels of GSH as compared to the control ***:Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation,specifically MDA-oxLDL.

关键词： coronavirus disease 2019 aminothiols oxidative stress interleukin-6 oxidized lipoproteins

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Blood concentration of aminothiols in children with relapse of nephrotic syndrome

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世界儿科杂志:英文版 2016年第3期12卷 353-359页

作者： Marcin Tkaczyk Monika Miklaszewska Jolanta Lukamowicz Wojciech Fendler Division of Nephrology Polish Mother's Memorial Hospital Research Institute of lodz281/289 Rzgowska st.93-338lodzPoland Department of Pediatric Nephrology Collegium Medicum of Jagiellonian UniversityWielicka 26530-663 KrakowPoland Center of Medical Diagnostics Polish Mother's Memorial Hospital Research Institute of lodzPoland281/289 Rzgowska st.93-338 lodzPoland Medical University of lodz al.Kosciuszki 4lodzPoland

Background:The role of idiopathic nephrotic syndrome(INS)in the pathogenesis of atherosclerosis in childhood has not been clearly ***,antioxidative defense in INS is thought to be *** study aimed to assess the changes of plasma concentration of selected aminothiols in the blood of children with INS at various stages of the ***:This cross-sectional study was conducted in 125 children aged 2-18 *** children were divided into 4 groups:group A,early relapse(n=37);group B,early remission for 4-6 weeks from the onset(n=37);group C,late steroid-free remission(n=31);and group D,long-term remission for 2-5 years(n=20).Control group(E)consisted of 30 age-and gender-matched healthy *** study protocol comprised an analysis of plasma concentrations of glutathione,homocysteine,cysteine and cysteinylglycine by high-performance liquid *** of protein-bound and free aminothiols were *** injury was assessed by thrombomodulin,PAI-1 concentration,and von Willebrand factor ***:The children with INS had unbalanced aminothiol metabolism only in relapse and early remission,that shifted towards increased oxidative *** of cyclosporine A caused a significant increase in homocysteine and cysteine *** in aminothiol metabolism were significantly related to endothelial ***:The fi ndings of this study may be helpful in elucidating the pathogenesis of premature atherosclerosis in patients with INS refractory to the treatment or in the case of frequent relapse.

关键词： aminothiols children cyclosporine A homocysteine nephrotic syndrome

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Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation

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World Journal of Hepatology 2018年第7期10卷 496-508页

作者： Neha Vithal Bhilare Suneela Sunil Dhaneshwar Kakasaheb Ramoo Mahadik Department of Pharmaceutical Chemistry Poona College of Pharmacy Bharati Vidyapeeth University

AIM To overcome the hazardous effects on liver caused by long-term use of antitubercular agent isoniazid(INH) by developing a novel hepatoprotective prodrug strategy by conjugating INH with aminothiols as antioxidant promoities for probable synergistic *** INH was conjugated with N-acetyl cysteine(NAC) and N-(2)-mercaptopropionyl glycine using the SchottenBaumann reaction and with L-methionine using Boc-anhydride through a biocleavable amide linkage. Synthesized prodrugs were characterized by spectral analysis, and in vitro and in vivo release studies were carried out using HPLC. Their hepatoprotective potential was evaluated in male Wistar rats by performing liver function tests, measuring markers of oxidative stress and carrying out histopathology *** Prodrugs were found to be stable in acidic(pH 1.2) and basic(pH 7.4) buffers and in rat stomach homogenates, whereas they were hydrolysed significantly(59.43%-94.93%) in intestinal homogenates over a period of 6 h. Upon oral administration of prodrug NI to rats, 52.4%-61.3% INH and 47.4%-56.8% of NAC were recovered in blood in 8-10 h. Urine and faeces samples pooled over a period of 24 h exhibited 1.3%-2.5% and 0.94%-0.9% of NAC, respectively, without any presence of intact NI or INH. Prodrugs were biologically evaluated for hepatoprotective activity. All the prodrugs were effective in abating oxidative stress and re-establishing the normal hepatic physiology. The effect of prodrug of INH with NAC in restoring the levels of the enzymes superoxide dismutase and glutathione peroxidase and abrogating liver damage was noteworthy especially. CONCLUSION The findings of this investigation demonstrated that the reported prodrugs can add safety and efficacy to future clinical protocols of tuberculosis treatment.

关键词： aminothiols antioxidants N-acetyl cysteine N-(2-mercaptopropionyl)glycine isoniazid L-methionine liver injury tuberculosis

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