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Study on the hepatoprotective effect of Sporidiobolus pararoseus polysaccharides under the“gut microbiome-amino acids metabolism”network

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Food Bioscience 2022年第5期49卷 1318-1326页

作者： Chang Liu Hanyi Hua Yahui Guo He Qian Jingfang Liu Yuliang Cheng State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Institutional Center for Shared Technologies and Facilities of Institute of Microbiology Chinese Academy of SciencesNO.1 Beichen West RoadChaoyang DistrictBeijing100101China

The“gut-liver”axis plays an important role in the mechanism of alcoholic liver disease(ALD).Sporidiobolus pararoseus polysaccharides(SPP)have been shown to improve the gut barrier and liver damage in mice with ***,the process is modulated via the gut microbiome and amino acids in the gut-liver axis has not been *** this study,the gut microbiome and metabolic function were explored for the mechanism by which SPP improve *** results showed that after the SPP were metabolized by ALD mice,microbial diversity was altered,and the relative abundances of Lachnospiraceae,Alistipes,Eubacterium siraeum,and Bacteroides *** predicted results of microbiome functions promoted the biosynthesis of amino acids,tyrosine,tryptophan,valine,leucine,and isoleucine were *** results also confirmed that butanoate metabolism and biosynthesis of phenylalanine,tyrosine,and tryptophan are the main regulatory pathways of *** gut microbiome metabolizes the hallmark metabolites of SPP were L-tyrosine,L-histidine,and *** analysis and interaction network deeply mine gut microbiome(Lachnospiraceae,Eubacterium siraeum,Erysipelotrichaceae),metabolites(L􀀀serine,L􀀀tyrosine),and metabolism(biosynthesis of amino acids,valine,leucine,and isoleucine biosynthesis)may be key factors in the SPP-gut microbiome-metabolites-metabolism in ALD ***,SPP have the effect of proliferating beneficial gut microbiome that metabolize polysaccharides,promoting the production of amino acids,and regulating liver metabolic disorders.

关键词： Sporidiobolus pararoseus polysaccharides Gut microbiome amino acids metabolism Bioinformatics

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