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Dietary Enteromorpha polysaccharide-Zn supplementation regulates amino acid and fatty acid metabolism by improving the antioxidant activity in chicken

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Journal of Animal Science and Biotechnology 2022年第3期13卷 878-896页

作者： Teketay Wassie Xinyi Duan Chunyan Xie Ruxia Wang Xin Wu Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionHunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionChangsha 410125HunanChina College of Bioscience and Biotechnology Hunan Agricultural UniversityChangshaChina Institute of Biological Resources Jiangxi Academy of SciencesNanchang 330096China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308PR China

Background:Enteromorpha prolifera(E.prolifera)polysaccharide has become a promising feed additive with a variety of physiological activities,such as anti-oxidant,anti-cancer,anti-diabetic,immunomodulatory,hypolipidemic,and cation chelating ability.However,whether Enteromorpha polysaccharide-trace element complex supplementation regulates amino acid and fatty acid metabolism in chicken is largely unknown.This study was conducted to investigate the effects of E.prolifera polysaccharide(EP)-Zn supplementation on growth performance,amino acid,and fatty acid metabolism in chicken.Methods:A total of 184 one-day-old Ross-308 broiler chickens were randomly divided into two treatment groups with 8 replicates,12 chickens per replicate,and fed either the basal diet(control group)or basal diet plus E.prolifera polysaccharide-Zinc(400 mg EP-Zn/kg diet).Results:Dietary EP-Zn supplementation significantly increased(Pamino acid digestibility and upregulate the mRNA expression of amino acid transporter genes in the jejunum,ileum,breast muscle,and liver tissues(Pamino acid content.Furthermore,EP-Zn supplementation upregulated(Pmetabolism by inhibiting the gene expression of key enzymes involved in the fatty acid synthesis and activating genes that participated in fatty acid oxidation in the liver tissue.Conclusions:It is concluded that EP-Zn comple

关键词： amino acid metabolism Antioxidant Chicken Enteromorpha prolifera Lipid metabolism Oxidative stress

Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy

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World Journal of Stem Cells 2022年第4期14卷 267-286页

作者： Qi Zhang Wei Li Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Cancer stem cells(CSCs)possess self-renewal and differentiation potential,which may be related to recurrence,metastasis,and radiochemotherapy resistance during tumor treatment.Understanding the mechanisms via which CSCs maintain self-renewal may reveal new therapeutic targets for attenuating CSC resistance and extending patient life-span.Recent studies have shown that amino acid metabolism plays an important role in maintaining the self-renewal of CSCs and is involved in regulating their tumorigenicity characteristics.This review summarizes the relationship between CSCs and amino acid metabolism,and discusses the possible mechanisms by which amino acid metabolism regulates CSC characteristics particularly self-renewal,survival and stemness.The ultimate goal is to identify new targets and research directions for elimination of CSCs.

关键词： amino acid metabolism Cancer stem cell Self-renewal Resistance

Characteristics of amino acid metabolism in colorectal cancer

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世界临床病例杂志 2023年第27期11卷 6318-6326页

作者： Fen Xu Hong-Liang Jiang Wei-Wei Feng Chen Fu Jiang-Chang Zhou Department of Gastroenterology Xinhua Hospital Affiliated to Dalian UniversityDalian 116000Liaoning ProvinceChina

In recent years,metabolomics research has become a hot spot in the screening and treatment of cancer.It is a popular technique for the quantitative characterization of small molecular compounds in biological cells,tissues,organs or organisms.Further study of the tumor revealed that amino acid changes may occur early in the tumor.The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids.An abundant supply of amino acids is important for cancer to maintain its proliferative driving force.Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes.Therefore,it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer.This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

关键词： Metabolomics amino acid metabolism Colorectal cancer Glutamine

Effects of adding sodium dichloroacetate to low-protein diets on nitrogen balance and amino acid metabolism in the portaldrained viscera and liver of pigs

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Journal of Animal Science and Biotechnology 2020年第3期11卷 884-895页

作者： Weizhong Sun Yunxia Li Zhiru Tang Huiyuan Chen Ke Wan Rui An Liuting Wu Zhihong Sun Laboratory for Bio-feed and Molecular Nutrition College of Animal Science and TechnologySouthwest UniversityChongqing 400715People’s Republic of China Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130People’s Republic of China

Background:Identifying regulatory measures to promote glucose oxidative metabolism while simultaneously reducing amino acid oxidative metabolism is one of the foremost challenges in formulating low-protein(LP)diets designed to reduce the excretion of nitrogen-containing substances known to be potential pollutants.In this study,we investigated the effects of adding sodium dichloroacetate(DCA)to a LP diet on nitrogen balance and amino acid metabolism in the portal-drained viscera(PDV)and liver of pigs.To measure nitrogen balance,18 barrows(40±1.0 kg)were fed one of three diets(n=6 per group):18%crude protein(CP,control),13.5%CP(LP),and 13.5%CP+100 mg DCA/kg dry matter(LP-DCA).To measure amino acid metabolism in the PDV and liver,15 barrows(40±1.0 kg)were randomly assigned to one of the three diets(n=5 per group).Four essential amino acids(Lys,Met,Thr,and Trp)were added to the LP diets such that these had amino acid levels comparable to those of the control diet.Results:The LP-DCA diet reduced nitrogen excretion in pigs relative to that of pigs fed the control diet(P0.05).There were no differences between the control and LP-DCA groups with respect to amino acid supply to the liver and extra-hepatic tissues in pigs(P>0.05).The net release of ammonia into the portal vein and production rate of urea in the liver of pigs fed the LP-DCA diet was reduced relative to that of pigs fed the control and LP diets(Pamino acids to the liver and extra-hepatic tissues.

关键词： amino acid metabolism Low-protein diet Nitrogen excretion Pig Sodium dichloroacetate

Reconstruction of Pathways Associated with amino acid metabolism in Human Mitochondria

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Genomics, Proteomics & Bioinformatics 2007年第3期5卷 166-176页

作者： Purnima Guda Chittibabu Guda Shankar Subramaniam Gen *NY* sis Center for Excellence in Cancer Genomics and Department of Epidemiology and Biostatistics State University of New York at AlbanyRensselaerNY 12144-3456USA San Diego Supercomputer Center University of California at San DiegoLa JollaCA 92093-0505USA Departments of BioengineeringChemistry and BiochemistryUniversity of California at San DiegoLa JollaCA 92093USA.

We have used a bioinformatics approach for the identification and reconstruction of metabolic pathways associated with amino acid metabolism in human mitochondria. Human mitochondrial proteins determined by experimental and computational methods have been superposed on the reference pathways from the KEGG database to identify mitochondrial pathways. Enzymes at the entry and exit points for each reconstructed pathway were identified, and mitochondrial solute carrier proteins were determined where applicable. Intermediate enzymes in the mitochondrial pathways were identified based on the annotations available from public databases, evidence in current literature, or our MITOPRED program, which predicts the mitochondrial localization of proteins. Through integration of the data derived from experimental, bibliographical, and computational sources, we reconstructed the amino acid metabolic pathways in human mitochondria, which could help better understand the mitochondrial metabolism and its role in human health.

关键词： mitochondria metabolic pathways amino acid metabolism human

Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye Yin-Hua Huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of DR.METHODS:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene sequencing.Sixty fecal samples from PDR,DM,and HC groups were assayed by untargeted metabolomics.Fecal metabolites were measured using liquid chromatographymass spectrometry(LC-MS)analysis.Associations between gut microbiota and fecal metabolites were analyzed.RESULTS:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were found.To be specific,the structure of gut microbiota differed in four groups.Diversity and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was observed.Functional analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC group.Arginine,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC group.Functional analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR group.Correlation analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal samples.CONCLUSION:This study elaborates the different microbiota structure in the gut from four groups.The relative abundance of Ruminococcaceae-UCG-002 and Parabacteroides are

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

Global research trends and prospects of cellular metabolism in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 527-542页

作者： Yan-Chen Liu Zhi-Cheng Gong Chao-Qun Li Peng Teng Yan-Yan Chen Zhao-Hui Huang Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through bibliometrics.AIM To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by visualization.METHODS Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer 1.6.19.RESULTS The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields.Meanwhile,China and the United States were two of the most prominent contri-butors in these four areas.In addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-Yuan Fang,Senji Hirasawa,Wei Jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in NM.CONCLUSION Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC.Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.

关键词： Cellular metabolism Colorectal cancer Glucose metabolism amino acid metabolism Lipid metabolism Nucleotide metabolism

From the imbalance of tumor amino acid metabolism,the application of fuzheng detoxification method in interfering with the transformation of colitis cancer was discussed

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Microenvironment & Microecology Research 2022年第3期4卷 15-18页

作者： Yi Li Gui-Jie Wang Lu Feng Bo Pang Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250014China

Objective:From the perspective of tumor amino acid metabolism imbalance,the application of fuzheng detoxification method in intervening in the transformation of colitis cancer was discussed.Methods:By consulting CNKI's concept of tumor microenvironment,energy metabolism,amino acid metabolism,and colitis cancer transformation,it provides theoretical and data support for research purposes.Results:The study found that the transformation of colitis cancer refers to the metabolic imbalance of the tumor microenvironment under the condition of repeated stimulation of chronic inflammatory responses of colon tissue,which is mainly related to energy metabolism,sugar metabolism,fat metabolism,and amino acid metabolism imbalance,which promotes the transformation of the inflammatory microenvironment to the tumor microenvironment.amino acids as an important source of nutrients for cells,its metabolic imbalance is an important cause of inflammation and cancer transformation.Conclusion:Chinese medicine believes that the transformation of inflammation and cancer is mainly related to the incurable treatment of evil in the internal organs,the loss of Qi,and the poison damage to the blood network.Colon cancer disease mechanism is always positive deficiency and stasis,the pathogenesis is based on the virtual standard,the virtual and real are mixed,and the clinical use of correct detoxification to adjust the balance of the body.

关键词： chronic colitis inflammatory carcinogenesis amino acid metabolism correct detoxification

Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-Li Zheng Department of Basic Medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal studies.AIM To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying mechanism.METHODS To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with LGZG.The determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance tests.Using a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic steatosis.It effectively controlled blood glucose and food intake while protecting islet cells.Metabolite analysis revealed significant differences between the HFD and HFDLGZG groups.LGZG intervention reduced branched-chain amino acid levels.Levels of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased significantly.IR may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by qRT-PCR.CONCLUSIONS Our study strongly suggests that LGZG decoction reduces HFD-induced IR.LGZG may activate S6K1 via metabolic pathways.These findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance amino acid metabolism S6K1