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Evaluation of retinal and choroidal changes in patients with alzheimer’s type dementia using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 860-868页

作者： Ze-Bing Li Zhong-Jing Lin Na Li Huan Yu Yan-Lin Wu Xi shen Department of Ophthalmology Ruijin HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

AIM:To evaluate the changes in fundus parameters in patients with alzheimer’s type dementia(ATD)using optical coherence tomography angiography(OCTA),to record flash electroretinograms(ERG)using the RETeval system and to explore changes in retinal ***:Twenty-nine patients with ATD and 26 age-matched normal subjects were *** subjects underwent OCTA scans to analyse the superficial retinal vessel parameters in the macular area,including the vessel length density,the vessel perfusion density and the area of foveal avascular zone(FAZ),as well as the choroidal *** differences between the patients with ATD and the normal control group were compared and explored the relevant factors affecting vessel *** also recorded the flash ERGs using the RETeval system and intended to explore changes in retinal function by analysing the ERG image amplitude in patients with ***:The vessel parameters[Pvessel length density=0.005 and Pvessel perfusion density=0.006]and average choroid thickness(Ps less than the control *** FAZ area was statistically significantly enlarged in the ATD group(Pse parameters were correlated with the Mini-Mental state Examination(MMsE)score and the Montreal Cognitive Assessment(MoCA).CONCLUsION:Patients with ATD exhibit decreases in the parameters associated with *** addition,these indicators significantly correlate with the MMsE score and the MoCA *** may be an adjunct tool with strong potential to track changes in the diagnosis and monitoring the progression of the disease.

关键词： optical coherence tomography angiography alzheimer’s type dementia Mini-Mental state Examination Montreal Cognitive Assessment scale RETeval system flash electroretinogram

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