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Numerical study on the thermal performance of packed-bed latent heat thermal energy storage system with biomimetic alveoli structure capsule

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Science China(Technological Sciences) 2021年第7期64卷 1544-1554页

作者： WANG FuQiang DONG Yan LI Yang XU Jie ZHANG GuoLiang School of Physics Harbin Institute of TechnologyHarbin150001China School of New Energy Harbin Institute of TechnologyWeihai264209China School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China College of Petroleum Engineering Liaoning Shihua UniversityFushun113001China

Bionics provides a positive and beneficial impact on the development of various materials and systems, which has been widely used in energy storage, heat transfer enhancement, and solar thermochemical reactions. In this paper, the idea of heat storage unit with biomimetic alveoli structure is proposed and introduced to increase the heat transfer area and improve the thermal performance of the packed-bed latent heat thermal energy storage(LHTES) system. The effects of heat storage unit structure on temperature distribution, liquid fraction, thermal storage capacity, and other performance indexes of the conventional model and biomimetic model are analyzed. The numerical results indicate that the biomimetic alveoli structure can improve the thermal response of heat storage unit, increase the specific surface area, and achieve a faster heat storage process of the packed-bed compared with the conventional structure. Among various existing models, the double-cell model has a significant *** with the conventional model, the maximum increase of liquid fraction and charging efficiency are 9.8% and 6.4%,respectively. This study can provide references to optimize packed-bed LHTES and improve its thermal performance under practical conditions.

关键词： solar energy thermal energy storage packed bed biomimetic alveoli phase change material

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Fegeneration of functional alveoli by adult human SOX9^＋ airway basal cell transplantation

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Protein & Cell 2018年第3期9卷 267-282页

作者： Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China Southwest Hospital Third Military Medical University of PLA Chongqing 400038 China Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China The Institute for Biomedical Engineering and Nano Science School of Medicine Tongji University Shanghai 200029 China Kiangnan Stem Cell Institute Zhejiang 311300 China Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China

Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9^＋ basal cells （BCs） located at airway epithelium rugae can regenerate adult human lung. Human SOX9^＋ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition. Expanded human SOX9^＋ BCs can give rise to alveolar and bronchiolar epithelium after being transplanted into injured mouse lung, with air-blood exchange system reconstructed and recipient＇s lung function improved. Manipulation of lung microenvironment with Pirfenidone to suppress TGF-β signaling could further boost the transplantation efficiency. Moreover, we conducted the first autologous SOX9^＋ BCs transplantation clinical trial in two bronchiectasis patients. Lung tissue repair and pulmonary function enhancement was observed in patients 3-12 months after cell transplantation. Alto- gether our current work indicated that functional adult human lung structure can be reconstituted by orthotopic transplantation of tissue-specific stem/progenitor cells, which could be translated into a mature regenerative therapeutic strategy in near future.

关键词： lung regeneration transplantation stem cell. bronchiectasis alveoli

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Epithelial stem cells and niches in lung alveolar regeneration and diseases

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 17-26页

作者： Jilei Zhang Yuru Liu Department of Pharmacology and Regenerative Medicine University of Illinois College of MedicineChicagoIL 60612USA University of Illinois Cancer Center ChicagoIL 60612USA

alveoli serve as the functional units of the lungs,responsible for the critical task of blood-gas ***-prising type I(AT1)and type II(AT2)cells,the alveolar epithelium is continuously subject to external aggressors like pathogens and airborne *** such,preserving lung function requires both the homeostatic renewal and reparative regeneration of this epithelial *** in these processes contribute to various lung *** research has pinpointed specific cell subgroups that act as potential stem or progenitor cells for the alveolar epithelium during both homeostasis and ***,endothelial cells,fibroblasts,and immune cells synergistically establish a nurturing microenvironment-or“niche”-that modulates these ep-ithelial stem *** review aims to consolidate the latest findings on the identities of these stem cells and the components of their niche,as well as the molecular mechanisms that govern ***,this article highlights diseases that arise due to perturbations in stem cell-niche *** also discuss recent technical innovations that have catalyzed these ***,this review underscores the heterogeneity,plastic-ity,and dynamic regulation of these stem cell-niche *** is our aspiration that a deeper understanding of the fundamental cellular and molecular mechanisms underlying alveolar homeostasis and regeneration will open avenues for identifying novel therapeutic targets for conditions such as chronic obstructive pulmonary disease(COPD),fibrosis,coronavirus disease 2019(COVID-19),and lung cancer.

关键词： alveoli Epithelium Type II cell(AT2) Stem cell Niche

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Sudden Death due to Diffuse Alveolar Hemorrhage Induced by Pul- monary Renal Syndrome： Two Case Reports

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法医学杂志 2015年第3期31卷 246-248页

作者： DENG Kai-fei SHEN Shan-shan CHEN Yi-jiu HUANG Ping Shanghai Key Laboratory of Forensic Medici. Institute of Forensic Science Ministry of Justice Shanghai 200063China Public Security Bureau of Nanshi District Baoding 071000 China

Patients developing hemoptysis or pulmonary infiltrates together with glomerulonephritis, particu- larly the rapidly progressive cases, are considered to be pulmonary renal syndrome （PRS）. The occur- rence of PRS, an etiologically rare heterogeneous group of diseases, constitutes a medical emergency associated with a high risk of fatal outcome.

关键词： forensic pathology death, sudden hemorrhage pulmonary alveoli pulmonary renal syndrome

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