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als3-Th-cell-epitope plus the novel combined adjuvants of CpG,MDP and FIA synergistically enhanced the immune response of recombinant TRAP derived from Staphylococcus aureus in mice

Als3-Th-cell-epitope plus the novel combined adjuvants of Cp...

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第十四届全国免疫学学术大会

作者： Jinzhu Ma Wei Liu Simiao Yu Baifen Song Yongzhong Yu Chunyu Tong Liquan Yu Yudong Cui Heilongjiang Bayi Agricultural University

Introduction:Staphylococcus aureus(***) is a gram-positive opportunistic pathogen,there are currently no high effective vaccine against *** in humans and animals,the development of an efficient vaccine remains an important challenge to prevent *** ***,we prepared als3-Th-cell-epitope-TRAP(ATT) proteins plus the novel combined adjuvants to develop a promising vaccine candidate against ***:The recombinant pET-28 a(+)-att plasmids were constructed,and the ATT proteins were expressed and obtained,then,ATT plus Freund’s adjuvant or the novel combined adjuvants of CpG,MDP and FIA were immunized in *** booster immunization,the levels of IFN-γ,IL-4,IL-10 and IL-17 A cytokine were evaluated,the humoral immune responses against TRAP were detected in mice,and the survival rate of mice was confirmed by challenge ***:The mice immunized with ATT plus Freund’s adjuvant exhibited significantly higher level of IFN-γ,IL-4,IL-1 0 and IL-17 A,and displayed the stronger humoral immune response against TRAP than control groups,importantly,the survival rate of these mice was significantly higher than control *** addition,compared with the control groups,ATT+CpG+MDP+FIA group was elicited significantly higher level of IFN-γ,IL-4,IL-10 and IL-17 A,and was triggered the stronger humoral immune responses against TRAP,moreover,generated the higher survival rate of ***:als3 epitopes significantly enhanced TRAP *** plus the novel combined adjuvants of CpG,MDP and FIA induced the strong immune response and protection against ***,revealing the combination of CpG,MDP and FIA adjuvant acts the synergistic effect.

关键词： als3 epitopes ATT,CpG MDP FIA Combined adjuvants

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