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Chromatographic fingerprint analysis and quantitative evaluate the rhizomes of alpinia officinarum hance(lesser galangal)

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Journal of Chinese Pharmaceutical Sciences 2019年第10期28卷 728-738页

作者： Haoyan Jiao Shengmei Xu Chunlin Fan Qingwen Zhang Ying Wang School of Pharmacy Guangdong Food and Drug Vocational CollegeGuangzhou 510520China Institute of Traditional Chinese Medicine&Natural Products College of PharmacyJinan UniversityGuangzhou 510000China JNU-HKUST Joint Laboratory for Neuroscience&Innovative Drug Research Jinan UniversityGuangzhou 510000China Institute of Chinese Medical Sciences University of MacaoMacao 999078China

The rhizome of alpinia officinarum hance is a well-known traditional Chinese medicine(TCM)and has been widely used for the remedy of gastrointestinal *** the present study,a simple and rapid HPLC-DAD was developed for the quality control of the rhizomes of *** chemical fingerprint was established using raw material of 15 different origins in *** analysis(SA)and hierarchical clusting analysis(HCA)were applied to select the qualitative *** components analysis(PCA)was conducted to select the quantitative markers of the rhizomes of *** samples from different *** constituents were confirmed by(+)electrospray ionization LC-MS.12 constituents were selected as common peaks and 10 of them were confirmed by(+)electrospray ionization *** bioactive constituents including DPHA,galangin flavanone,galangin,galangin 3-methylether,DPHB and DPHC were simultaneous determination by using the HPLC-DAD *** developed method was able to determine the bioactive components with excellent resolution,precision and *** results indicated that chromatographic fingerprint combination with multi-components determination method is suitable for quality assessment of the rhizomes of ***.

关键词： alpinia officinarum hance Simultaneous determination Chromatographic fingerprint Quality evaluation Traditional Chinese medicine

Herb-drug interaction in the protective effect of alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats

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Journal of Pharmaceutical Analysis 2021年第2期11卷 200-209页

作者： Xuguang Zhang Zhenrui Xie Xun Chen Junqiang Qiu Yinfeng Tan Xiaoliang Li Hailong Li Junqing Zhang Key Laboratory of Tropical Translation Medicine of Ministry of Education Hainan Provincial Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou571199China

alpinia officinarum hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effects. However, the role of herb-drug interaction between indomethacin and A. officinarum based on pharmacokinetic, tissue distribution and excretion still remains unknown. In this study, an ultra-fast liquid-tandem mass spectrometry(UFLC-MS/MS) method was developed for simultaneous determination of indomethacin and its three metabolites, O-desmethylindomethacin(ODI), deschlorobenzoylindomethacin(NDI) and indomethacin acyl-b-D-glucuronide(IDAbG) by oral administration of indomethacin solution with and without the ethanolic extract of A. officinarum and applied to comparative pharmacokinetic, tissue distribution and excretion studies. Our results clarified that oral administration of A. officinarum produced significant alterations in the pharmacokinetic parameters of indomethacin. And the pharmacokinetic interaction between indomethacin and A. officinarum reduced the systemic exposure of indomethacin and increased its elimination. Tissue distribution results demonstrated that co-administration of A. officinarum could not reduce the accumulation of indomethacin in the target tissue of the stomach, but could accelerate the excretions of indomethacin and its three metabolites including ODI, NDI and IDAb G in the bile and feces of rats in the excretion ***, A. officinarum might have a gastrointestinal protective effect through the interaction role with indomethacin based on the pharmacokinetics and excretion in rats.

关键词： alpinia officinarum hance Indomethacin Herb-drug interaction Pharmacokinetics Tissue distribution Excretion

A new dimeric diarylheptanoid from the rhizomes of alpinia officinarum

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Chinese Journal of Natural Medicines 2014年第2期12卷 139-141页

作者： LIU Dan QU Wei ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu Department of Natural Medicinal Chemistry China Pharmaceutical University College of Biotechnology and Pharmaceutical Engineering Wuhan Polytechnic University Institute of Botany Jiangsu Province and Chinese Academy of Science

AIM: To study the chemical constituents of the rhizomes of alpinia officinarum hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named alpinin B(1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B(1), 1, 7-diphenyl-3,5-heptanedione(2),(4E)-1, 7-diphenylhept-4-en-3-one(3) and(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol L 1.

关键词： alpinia officinarum hance diarylheptanoid alpinin B 1,7-diphenyl-3,5-heptanedione (4E)-l,7-diphenylhept-4-en -3-one