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Hereditary hemochromatosis:Temporal trends,sociodemographic characteristics,and independent risk factor of hepatocellular cancer–nationwide population-based study

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World Journal of Hepatology 2022年第9期14卷 1804-1816页

作者： Maryam Bilal Haider Ali Al Sbihi Ahmed Jamal Chaudhary Syed M Haider Ahmed Iqbal Edhi Department of Internal Medicine Detroit Medical CenterWayne State UniversitySinai Grace HospitalDetroitMI 48235United States System Science Binghamton UniversityBinghamtonNY 13902United States Department of Gastroenterology William Beaumont HospitalRoyal OakMI 48073United States

BACKGROUND Hereditary hemochromatosis(HH)has an increased risk of hepatocellular cancer(HCC)both due to genetic risks and iron overload as iron overload can be carcinogenic;HH impacts the increasing risk of HCC,not only through the development of cirrhosis but concerning hepatic iron deposition,which has been studied further *** To evaluate HH yearly trends,patient demographics,symptoms,comorbidities,and hospital *** secondary aim sheds light on the risk of iron overload for developing HCC in HH patients,independent of liver cirrhosis *** study investigated HH(without cirrhosis)as an independent risk factor for *** We analyzed data from National Inpatient Sample(NIS)Database,the largest national inpatient data collection in the United States,and selected HH and HCC *** was first defined in 2011 International Classification of Disease-9th edition(ICD-9)as a separate diagnosis;the HH cohort is extracted from January 2011 to December 2019 using 275.01(ICD-9)and E83.110(ICD-10)diagnosis codes of *** were excluded from the HH cohort if they had a primary or secondary diagnostic code of cirrhosis(alcoholic,non-alcoholic,and biliary),viralhepatitis,alcoholic liver disease,non-alcoholic fatty liver disease(NAFLD),and non-alcoholic steatohepatitis(NASH).We removed these patients from the HH cohort to rule out bias or ICD-10 diagnostic *** HCC cohort is selected from January 2011 to December 2019 using the ICD-9 and ICD-10 codes of *** selected a non-HCC cohort with the 1:1 fixed ratio nearest neighbor(greedy)propensity score method using the patients'age,gender,and *** performed multivariate analysis for the risk factors of HCC in the HCC and non-HCC matched *** further analyzed HH without cirrhosis(removing HH patients with a diagnosis of cirrhosis)as an independent risk factor of HCC after adjusting all known risk factors of HCC in the multivariate *** During the 2011-2019 period,a total o

关键词： Hereditary hemochromatosis Hepatocellular carcinoma,cirrhosis Hepatitis Diabetes mellitus Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Wilson disease alpha1-antitrypsin deficiency Blood transfusion Epidemiology Demographics Big data Hospitalization

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