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Antibiofilm activity of alpha-mangostin loaded nanoparticles against Streptococcus mutans

Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 325-332页

作者： Phuong T.M.Nguyen Minh T.H.Nguyen Lien T.Quach Phuong T.M.Nguyen Lam L.Nguyen Dong V.Quyen Institute of Biotechnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Institute of Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam University of Science and Technology of Hanoi Vietnam Academy of Science and Technology18-Hoang Quoc Viet RoadCau GiayHanoiVietnam

Objective:To investigate the antibiofilm activity of alphamangostin(AMG)loaded nanoparticle(nano AMG)against dental caries pathogen Streptococcus ***:AMG was isolated from the peels of Garcinia mangostana *** silica gel columns and chemically analysed by high performance liquid chromatography and nuclear magnetic *** AMG was prepared using the solvent evaporation method combined with high-speed *** nanoparticles were characterized using dynamic light scattering,field emission scanning electron microscopy(FE-SEM)and Fourier transform infrared spectroscopy(FTIR).The toxicity of nano AMG in fibroblast NIH/3 T3 cell line was determined using MTT *** antibiofilm effect of nano AMG was determined through the evaluation of biofilm formation by Streptococcus mutans using a 96-well *** biomass was quantified using crystal *** viability was observed under confocal microscopy using LIVE/DEAD Bac Light ***,gene expression was determined by quantitative real-time PCR and membrane permeabilization activity by measuring the uptake of o-nitrophenol-β-***:Nano AMG size was in a range of 10-50 nm with a polydispersity index of<0.3 and zeta potential value of-35.2 m *** size and the incorporation of AMG in the nanoparticles were confirmed by FE-SEM and FTIR *** IC50 values of the test agents on NIH/3 T3 cells were(9.80±0.63)μg/m L for AMG and(8.70±0.81)μg/m L for nano AMG,while no toxicity was generated from excipients used to prepare *** the early stage of biofilm formation,treatment with 6.25μmol/L nano AMG caused a reduction in biofilm biomass up to 49.1%,compared to 33.4%for *** contrast,biofilms at the late stage were more resistant to the test *** 96μmol/L(=10×MIC),nano AMG reduced only 20.7%of biofilm biomass while AMG did not showany *** of gtf B and gtf C genes involved in biofilm formation were down-regulated 3.3 and 12.5 folds,res

关键词： alpha-mangostin Nanoparticle Antibiofilm activity Streptococcus mutans

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Preparation and evaluation of alpha-mangostin solid self-emulsifying drug delivery system

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 225-226页

作者： Kun Sodalee Pimchanok Sapsuphan Ratta Wongsirikul Satit Puttipipatkhachorn Department of Manufacturing Pharmacy Faculty of PharmacyMahidol UniversityBangkok 10400Thailand Center of Excellence in Innovative Drug Delivery and Nanomedicine Faculty of PharmacyMahidol UniversityBangkok 10400Thailand

alpha-mangostin(AMG),a natural xanthone extracted from Garcinia mangostana Linn,has a variety of pharmacological therapeutic effects such as antioxidant activity,antibacterial activity,anticancer,and anti-inflammatory[1].However,it has poor aqueous-solubility and dissolution,which results in low *** self-emulsifying drug delivery system(solid-SEDDS),an effective pharmaceutical strategy,offers the potential for enhancing the oral bioavailability of poorly water-soluble drugs[2].Therefore,solid-SEDDS is of interest as a potential method for enhancing the solubility and dissolution of AMG.

关键词： alpha-mangostin Solid self-emulsifying drug delivery system Solubility Solid carrier

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The Influence of Drying Temperature and Extraction Methods on a-mangostin in Mangosteen Pericarp

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Journal of Food Science and Engineering 2011年第2期1卷 85-92页

作者： W. Satong-aun R. Assawarachan A. Noomhorm Food Engineering and Bioprocess Technology School of Environment Resources and Development Asian Institute of TechnologyKlong Luang Pathumthani 12120 Thailand Faculty of Engineering and Agro-lndustry Maejo University Sansai Chiang Mai 50290 Thailand

The effects of drying temperature and extraction methods on α-mangostin content in mangosteen pericarp （Garcinia mangostana L.） powder were investigated. In the first part of experiment suitable drying temperature for retention α-mangostin content was determined. Three levels of drying temperatures （55, 65 and 75 ℃） were used in this study. The drying rates were increased with drying temperature. Room temperature extraction method was performed to investigate the effect of drying temperature on retention α-mangostin content in mangosteen pericarp. The α-mangostin content extracted at three different drying temperatures （55, 65 and 75 ℃） was 35.98 ± 0.49%, 40.32 ± 0.24%, and 37.79±0.34% w/w, respectively. The results showed that the suitable temperature for drying mangosteen pericarp was 65 ℃ that gave the highest of α-mangostin content. The second part of experiment was the comparison between extraction methods, such as shaking water bath extraction （SWE）, soxhlet extraction （SE） and microwave-assisted extraction （MAE）. The results show that MAE gave the highest extraction rate and α-mangostin content as compare to SWE and SE. The α-mangostin content extraction from SWE, SE and MAE are 45.83 ± 0.02, 34.82± 0.17 and 49.79 ± 0.15% w/w of crude extract, respectively.

关键词： Mangosteen pericarp alpha-mangostin hot air drying room temperature extraction water bath extraction soxhletextraction microwave-assisted extraction.

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