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Serum proteins in chronic hepatitis B patients treated with peginterferon alfa-2b

World Journal of Gastroenterology 2013年第31期19卷 5067-5075页

作者： Sunida Kuakarn Poorichaya SomParn Pisit Tangkijvanich Varocha Mahachai Visith Thongboonkerd Nattiya Hirankarn Medical Microbiology Interdisciplinary Program Graduate School Chulalongkorn University Bangkok 10330 Thailand Immunology Unit Department of Microbiology Faculty of Medicine Chulalong-korn University Bangkok 10330 Thailand Department of Biochemistry Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Medical Proteomics Unit Office for Research and Development Faculty of Medicine Siriraj HospitalMahidol University Bangkok 10700 Thailand Center for Research in Complex Systems Science Mahidol University Bangkok 10700 Thailand

AIM: To study the differential protein profile in serum of hepatitis B ***: Serum samples were obtained from patients with chronic hepatitis B who were receiving peginterferon *** serum samples were subjected to albumin depletion and analyzed by two-dimensional gel electrophoresis(2-DE).Differentially expressed protein spots were identified by electrospray ionizationquadrupole time-of-flight mass ***2-hs-glycoprotein,complement component C3c and CD5 antigen were further analyzed by an enzymelinked immunosorbent assay and ***: Nineteen patients with HBeAg-positive chronic hepatitis B(CHB) were *** patients were followed for at least 1 year after treatment and were classified according to their treatment response: responders(n = 9) and non-responders(n = 10).2-DE and MS/MS analysis were performed to compare the serum proteins before initiating peginterferon *** the quantitative analysis of the 2-D gel,7 proteins were detected between the two groups at different levels before *** these potential candidates,serum levels of alpha-2-hs-glycoprotein,complement component C3c and CD5 antigen-like precursor were further *** the validation phase,23 subjects,9 sustained responders and 14 nonresponders,were ***,the levels of alpha-2-hs-glycoprotein and complement component C3c were elevated in the serum of the non-responders compared to the ***: Serum alpha-2-hs-glycoprotein and complement component C3c may be potential serum biomarkers in predicting the treatment response of peginterferon alfa-2b in patients with CHB prior to treatment.

关键词： Proteomics Peginterferon alfa-2b Chronic hepatitis B alpha-2-hs-glycoprotein Serum

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Role of fetuin A in the diagnosis and treatment of joint arthritis

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World Journal of Orthopedics 2017年第6期8卷 461-464页

作者： Eleni Pappa Despina S Perrea Spiridon Pneumaticos Vasileios S Nikolaou Laboratory of Experimental Surgery "N.S.Christeas" National and Kapodistrian University of AthensSchool of Medicine 3~(rd) Department of Orthopaedics KAT HospitalNational and Kapodistrian University of AthensSchool of Medicine 2~(nd) Department of Orthopaedics Agia Olga HospitalNational and Kapodistrian University of AthensSchool of Medicine

Osteoarthritis is a slowly progressive disease which includes the intervention of several cytokines, macrophage metalleinoproteinases reaction, leading to the degradation of the local cartilage but also having an impact on the serum acute phase proteins(APPs). Subsequently, biomarkers seem to be essential to estimate its progression and the need for any surgical intervention such as total arthroplasty, but also can be used as therapeutic agents. Recently, among APPs, fetuin A drew attention regarding its possible anti-inflammatory role in animal models but also as a therapeutic agent in the inflammatory joint disease in clinical trials. In contrast with other APPs such as C-reactive protein, fetuin A appears to be lower in the serum of patients with degenerative joint disease in comparison with the healthy ones, and also acts as an antagonist of the anti-proliferative potential of transforming growth factor-b(TGF-b) cytokines. Because of its lower serum levels in arthritis, an unregulated binding of TGF-b and bone morphogenetic proteins takes place leading to further arthritic lesions. The purpose of the present review is to assess the current evidence regarding the multipotent role of the alpha-2-hsglycoprotein or as also known Fetuin-a in animal models but also as a biomarker of the degenerative joint arthritis in clinical trials.

关键词： Fetuin A Arthritis alpha-2-hs-glycoprotein Bone morphogenetic protein Inflammation glycoprotein Treatment

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