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Associations of Polymorphism of rs9944155, rs1051052, and rs1243166 Locus Allele in alpha-1-antitrypsin with Chronic Obstructive Pulmonary Disease in Uygur Population of Kashgar Region

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Chinese Medical Journal 2018年第6期131卷 684-688页

作者： Xue-Mei Zhong Li Li Huai-Zhen Wang Xiao-Guang Zou Ping Zhang Mireban Rexiati Maimaitiaili Tnerxun Jie Ren Mukeremu Yasen Juan Zhang Ai-Fang Zheng Paierda Aini Department of Respiration The First People's Hospital of Xinjiang Kashgar Area Kashgar Xinjiang 844000 China

Background： Previous studies conducted in various geographical and ethnical populations have shown that alpha-1 -antitrypsin （alpha-1-AT） expression affects the occurrence and progression of chronic obstructive puh-nonary disease （COPD）. We aimed to explore the associations of rs9944155AG, rsl051052AG, and rs1243166AG polymorphisms in the A lpha-1-A T gene with the risk of COPD in Uygur population in the Kashgar region. Methods： From March 2013 to December 2015. a total of 225 Uygur COPD patients and 198 healthy people were recruited as cases and controls, respectively, in Kashgar region. DNA was extracted according to the protocol of the DNA genome kit, and Sequenom MassARRAY single-nucleotide polymorphism technology was used for genotype determination. Serum concentration of alpha-1-AT was detected by enzyme-linked immunosorbent assay. A logistic regression model was used to estimate the associations of polymorphisms with COPD. Results： The rs1243166-G allele was associated with a higher risk of COPD （odds ratio [OR] = 2.039, 95% confidence interval [CI]： 1.116-3.725, P = 0.019）. In cases, alpha-1-AT levels were the highest among participants can-yiug rs1243166 AG genotype, followed by AA and GG genotype （χ2 = 11.89, P = 0.003）. Similarly, the rs1051052-G allele was associated with a higher risk of COPD （OR = 19.433, 95% CI： 8.783-43.00, P 〈 0.001）. The highest alpha-1-ATlevels were observed in cases carrying rs1051052 AA genotype, followed by cases with AG and GG genotypes （χ2= 122.45, P 〈 0.001）. However, individuals with rs9944155-G allele exhibited a lower risk of COPD than those carrying the rs9944155-A allele （OR = 0.121, 95% CI： 0.070-0.209, P 〈 0.001 ）. in both cases and controls, no significant difference in alpha-l-AT levels was observed among various rs9944115 genotypes. Conclusions： rs 1243166, rs9944155, and rs 1051052 sites of alpha- I-A Tmay be associated with the COPD morbidity in Uygur population. While rs 1243166-G allele and rs1051052-G allele a

关键词： alpha-1-antitrypsin Chronic Obstructive Pulmonary Disease Polymorphism Uygur Population

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DETECTION OF alpha-1 ANTICHYMOTRYPSIN IN HEPATOCELLULAR CARCINOMA TISSUE

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Chinese Journal of Cancer Research 1991年第3期3卷 56-59页

作者：荆雪枫于佩良

One hundred and fifty-three consecutive cases of HCC and 25 controls from autopsy material were studied by immunohistochemical method in this paper. A review of the histopathology and demonstration of AFP, alpha- 1-antichymotrypsin (AACT), alpha 1-antitrypsin (AAT) and CEA were *** the tumor markers. AACT yielded the highest positive rate, 109 cases (71%) out of 153 HCC. CEA was the next, 95 cases (62%) .AFP and AAT gave the same result, 72 cases (47%) . AACT, AAT and CEA were not found in the controls. AFP was present in a few hepatocytes in 1 of 25 controls. The results were in keeping with serum tests so far as the highest positive rate being AACT was concerned. Therefore, combined determination of AACT and AFP would seem a better screening method than by that of AFP alone for survey of HCC.

关键词： alpha fetal protein alpha- 1-antichymotrypsin alpha-1-antitrypsin hepatoma.

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Protein-loosing enteropathy associated with rotavirus infection in an infant

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World Journal of Gastroenterology 2008年第10期14卷 1630-1632页

作者： Tadashi Iwasa Nobuyuki Matsubayashi Department of Pediatrics Mie University Graduate School of Medicine Tsu Mie Japan Department of Pediatrics Shima Prefectural Hospital Shima Mie Japan

Rotavirus is an acute enteric pathogen in infants and children. We reported a rare case of a 6-mo-old infant with protein-loosing enteropathy (PLE) caused by rotavirus gastroenteritis, and evaluated the immunological profile in peripheral blood lymphocytes. Laboratory examinations showed lymphopenia, hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and elevation of alpha-1-antitrypsin (α1-AT) clearance. Lymphocytes subpopulation study revealed the reversal of CD4+/CD8+ ratio with the selective decrease of CD4- positive lymphocytes. Moreover, the excessive increase of T cells producing IFN-gamma (IFN-γ) was found, which plays an important role in the protection against viral infection. The primary or secondary activation of immune system by rotavirus may influence structural integrity and vascular permeability, which may play a triggering role in protein-loosing enteropathy.

关键词： Protein-loosing enteropathy Rotavirus Lymphocytes producing IFN-γ alpha-1-antitrypsin Reversal of CD4+/CD8+ ratio

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