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Measurement Uncertainty Assessment for Determination of allura red in Puffed Food by HPLC

Current Medical Science 2018年第2期38卷 324-328页

作者： Ying CHEN Yun ZHAO Hua-Ming WANG Qing WANG Xi CHEN Dong-qun XU Tao LI Feng YU Xiao-yong WANG Jia-fa LIU Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 China Department of Obsterics Maternal and Child Health Hospital of Hubei Province Wuhan 430070 China Institute for Environmental Health and Related Product Safety Chinese Center for Disease Control and Prevention Beijing100021 China Public Hospital Administration of Hubei Province Health And Family Planning Commission of Hubei Province Wuhan430079 China

This study aimed to assess the measurement uncertainty of a new method for determination of allura redin food by high performance liquid chromatography （HPLC）. The uncertainty of mathematical model of allura red is based on Europe for Analytical Chemistry（EURACHEM） guidelines. The sources and components of uncertainty were calculated, including recovery, working solution, sample mass, final volume, response of standard solution, response of sample solution. The expanded uncertainty was 0.0024 （k=2）. Uncertainty of working solution was the most significant factor contributing to the total uncertainty, accounting for 86.2%. The uncertainty of volume accounted for the minimum at 0.025%. The developed method is simple and accurate, which can be used for the determination of allura redin puffed samples.

关键词： uncertainty assessment allura red high performance liquid chromatography

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IFN-γ^(+) cytotoxic CD4^(+) T lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant red 40

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Cellular & Molecular Immunology 2022年第7期19卷 777-790页

作者： Lili Chen Zhengxiang He Bernardo S.Reis Jesse D.Gelles Jerry Edward Chipuk Adrian T.Ting Julie A.Spicer Joseph A.Trapani Glaucia C.Furtado Sergio A.Lira Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Laboratory of Mucosal Immunology The Rockefeller UniversityNew YorkNY 10065USA Department of Oncological Sciences Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Diabetes Obesityand Metabolism InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Immunology Mayo ClinicRochesterMN 55905USA Auckland Cancer Society Research Centre Faculty of Medical and Health SciencesThe University of AucklandPrivate Bag 92019Auckland 1142New Zealand Cancer Immunology Program Peter MacCallum Cancer Centre305 Grattan StreetMelbourneVIC 3000Australia

The food colorant red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-*** immune response is mediated by CD4^(+)T cells,but mechanistic insights into how these CD4^(+)T cells trigger andperpetuate colitis have remained ***,using single-cell transcriptomic analysis,we found that several CD4^(+)T-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing *** vivo challenge of primed mice withred 40 promoted rapid activation of CD4^(+)T cells and caused marked intestinal epithelial cell(IEC)apoptosis that was attenuated bydepletion of CD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal CD4^(+)T cells from colitic mice directlypromoted apoptosis of IECs and intestinal ***4^(+)T cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target *** ablation of IFN-γconstrained IL-23-and red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in *** results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic CD4^(+)T cells as a newpotential therapeutic target for colitis.

关键词： allura red IL23 Cytotoxic CD4^(+)T cells CD4^(+)CTL Inflammation Epithelium damage Colitis

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