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Platinum-copper alloy nanoparticles armored with chloride ion transporter to promote electro-driven tumor inhibition

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Bioactive Materials 2022年第6期7卷 143-152页

作者： Tong Chen Gaorong Han Xiang Li State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouZhejiang310027China ZJU-Hangzhou Global Scientific and Technological Innovation Centre Zhejiang UniversityHangzhou311200PR China

The induction of oxidative species,driven by oscillating electric field(E),has recently emerged as an effective approach for tumor inhibition,so-called electrodynamic therapy(EDT).While it offers a series of advantages attracting considerable attention,the fundamental mechanism and improvement strategies for EDT approach are being endeavored extensively with the aid of new material explorations.An interesting phenomenon observed in early studies is that the on-site concentration of chloride ion is highly favored for the induction of oxidative species and the efficacy of tumor inhibition.Following this discovery ignored previously,here for the first time,fine Pt/Cu alloy nanoparticles(PtCu_(3) NPs)are integrated with chloride ion transporter(CIT)for EDT-based combinational therapy.In this system,while PtCu_(3) NPs induce oxidative species under an electric field,it also effectively transforms endogenous H_(2)O_(2) into·OH and consumes intracellular glutathione(GSH).More importantly,with the aid of CIT,PtCu_(3)-PEG@CIT NPs promote the intracellular concentration of chloride ion(Cl^(-))by transporting extracellular Cl^(-),facilitating the generation of oxidative species considerably.Meanwhile,CIT delivered intracellularly increases lysosomal pH,leading to the disruption of cellular autophagy and weakening the treatment resistance.In consequence,significant tumor inhibition is enabled both in vitro and in vivo,due to the combination of unique characteristics offered by PtCu_(3)-PEG@CIT.

关键词： Electrodynamic therapy Chloride ion transporter alloy nanoparticles

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Facile fabrication of ultrafine nickel-iridium alloy nanoparticles/graphene hybrid with enhanced mass activity and stability for overall water splitting

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Journal of Energy Chemistry 2020年第10期29卷 166-173页

作者： Shen Zhang Xing Zhang Xuerong Shi Feng Zhou Ruihu Wang Xiaoju Li Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007FujianChina State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina School of Material Engineering Shanghai University of Engineering Science333 Longteng RoadSongjiang DistrictShanghai 201620China

Developing active and durable electrocatalysts for overall water splitting is desirable but challenging to realize sustainable hydrogen production.Here,we report a facile and general method to prepare ultrafine nickel(Ni)-iridium(Ir)alloy nanoparticles/graphene hybrids for overall water splitting.The optimized hybrid with 4.9 wt%Ir exhibits much higher catalytic activity and durability than commercial 20 wt%Ir/C for both oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).Theoretical simulations reveal that the incorporation of Ir in metallic Ni lattice regulates hydrogen adsorption free energy to the optimum level,thus improving HER activity,while in situ generated amorphous Ir-Ni hydr(oxy)oxides around metallic Ni-Ir core have been demonstrated to be the active species under OER conditions,which switches OER rate-determining step to energy-favorable pathway.The overall water splitting electrolyzer assembled by the optimized electrocatalyst shows a low cell voltage of only 1.52 V and excellent stability to deliver a current density of 10 m A cm-2.This work provides a powerful strategy toward general synthesis of ultrafine alloy nanoparticles for high-performance overall water splitting.

关键词： alloy nanoparticles Iridium Electrocatalysts Water splitting Mass activity

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Improved cell performance and sulphur tolerance using A-site substituted Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)anodes for solid-oxide fuel cells

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Clean Energy 2023年第1期7卷 70-83页

作者： Haixia Li Wanhua Wang Jie Lin Ka-Young Park Taehee Lee Andreas Heyden Dong Ding Fanglin Chen Department of Mechanical Engineering University of South CarolinaColumbiaSC29208USA Department of Chemical Engineering University of South CarolinaColumbiaSC29208USA Energy&Environmental Science and Technology Idaho National LaboratoryIdaho FallsID83401USA

Solid-oxide fuel cells(SOFCs)offer great promise for producing electricity using a wide variety of fuels such as natural gas,coal gas and gasified carbonaceous solids;however,conventional nickel-based anodes face great challenges due to contaminants in readily available fuels,especially sulphur-containing compounds.Thus,the development of new anode materials that can suppress sulphur poisoning is crucial to the realization of fuel-flexible and cost-effective SOFCs.In this work,La_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(LSFNM)and Pr_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(PSFNM)materials have been synthesized using a sol-gel method in air and investigated as anode mater-ials for SOFCs.Metallic nanoparticle-decorated ceramic anodes were obtained by the reduction of LSFNM and PSFNM in H_(2)at 850℃,forming a Ruddlesden-Popper oxide with exsolved FeNi3 bimetallic nanoparticles.The electrochemical performance of the Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)ceramic anode was greatly enhanced by La doping of A-sites,resulting in a 44%decrease in the polarization resistance in reducing atmosphere.The maximum power densities of Sr-and Mg-doped LaGaO_(3)(LSGM)(300μm)electrolyte-supported single cells with LSFNM as the anode reached 1.371 W cm^(-2)in H_(2)and 1.306 W cm^(-2)in 50 ppm H_(2)S-H_(2)at 850℃.Meanwhile,PSFNM showed improved sulphur tolerance,which could be fully recovered after six cycles from H_(2)to 50 ppm H_(2)S-H_(2)operation.This study indicates that LSFNM and PSFNM are promising high-performance anodes for SOFCs.

关键词： A-site doping perovskite Ruddlesden-Popper structure alloy nanoparticles polarization resistance solid oxide fuel cells

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