检索结果-南通市图书馆

allotopic expression of mitochondrial genes:Basic strategy and progress

Genes & Diseases 2020年第4期7卷 578-584页

作者： I.Made Artika Department of Biochemistry Faculty of Mathematics and Natural SciencesBogor Agricultural UniversityDarmaga CampusBogor 16680Indonesia Eijkman Institute for Molecular Biology Jalan Diponegoro 69Jakarta10430Indonesia

allotopic expression of mitochondrial genes is a deliberate functional relocation of mitochondrial genes into the nucleus followed by import of the gene-encoded polypeptide from the cytoplasm into the *** successful allotopic expression of a mitochondrial gene,several key aspects must be *** include the different codon dictionary used by the mitochondrial and nuclear genomes,different codon preferences between mitochondrial and nuclear-cytosolic translation systems,and the provision of an import signal to ensure that the newly translated protein in the cytosol is successfully imported into *** allotopic expression strategy was first developed in yeast,a useful model organism for studying human and other eukaryotic ***,a number of mitochondrial genes have been successfully recoded and nuclearly expressed in yeast and human *** addition to its use in evolutionary and molecular biology studies,the allotopic expression strategy has been developed as a potential approach to treat mitochondrial genetic *** progress has been recently achieved,and the development of this technique for therapy of the mitochondrial disease Leber’s hereditary optic neuropathy(LHON)has entered phase III clinical ***,a number of challenges remain to be overcome to accelerate the successful application of this *** include improvement of nuclear gene expression,import into mitochondria,processing,and functional integration of the allotopically expressed polypeptides into mitochondrial protein *** review discusses the current basic strategy,progress,challenges,and prospects of the allotopic expression strategy for mitochondrial genes.

关键词： allotopic expression Gene therapy Mitochondria Mitochondrial gene Protein targeting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：