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Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety Disorders and allostatic Load under Alprazolam Treatment

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Open Journal of Psychiatry 2019年第2期9卷 138-152页

作者： Carlos A. Soria Carolina Remedi Luciana D’Alessio Emilio J. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University CONICET Buenos Aires Argentina Scientific Direction Gador SA Buenos Aires Argentina

Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAD (general anxiety disorders, DSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > ?2 standard deviation (SD) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAD patients. Stratified treatments analyzing age and sex factors, including allostatic load measurements and cognitive assessments may be useful tools to determine the effectiveness and the safety of psychopharmacological treatments.

关键词： Verbal Fluency Test Chronic Stress allostatic Load Sex Age

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Open Journal of Psychiatry 2018年第3期8卷 212-232页

作者： Carlos A. Soria Carolina Remedi Luciana D’Alessio Emilio J. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University ENyS-CONICET Buenos Aires Argentina Scientific Direction Department Gador SA Buenos Aires Argentina

Introduction: allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.

关键词： Chronic Stress Neuroticism Alprazolam Anxiety allostatic Load

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Neuropsychology in ischemic stroke:stress,allostasis and allostatic load

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Journal of Translational Neuroscience 2017年第2期2卷 1-6页

作者： Ling Guan Jean-Paul Collet Department of Medicine The University of British ColumbiaVancouver V5Z 1M9Canada Department of Pediatrics The University of British ColumbiaVancouver V6H 0B3Canada BC Children’s Hospital Research Institute The University of British ColumbiaVancouver V5Z 4H4Canada

As a complicated cerebrovascular disorder,ischemic stroke involves a series of mind-body ***“stress”refers to a state of threatened homeostasis caused by any form of internal or external disturbing ***“stress response”is a counteracting force that neutralizes the effects of stressors and re-establish homeostasis,which may cause two different outcomes,the allostasis and allostatic *** prompt stress system is the autonomic nervous system(ANS)with two branches the sympathetic(SNS)and parasympathetic(PNS)nervous systems that play an important role in regulating stress *** a typical example and final endpoint of allostatic load,ischemic stroke and its complications are related to stress and autonomic *** clinical tests are described for assessing autonomic function in ischemic *** review may bring possibilities for future study to investigate specific treatment on ANS function and stress management on the context of traditional stroke therapies,and thus help improve the clinical outcomes and prognosis of ischemic stroke.

关键词： ischemic stroke stress allostasis allostatic load autonomic nervous system

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