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Effects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium

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Journal of Geriatric Cardiology 2016年第4期13卷 316-325页

作者： Yi-Cheng FU Yu ZHANG Liu-Yang TIAN Nan LI Xi CHEN Zhong-Qi CAI Chao ZHU Yang LI Division of Cardiology Chinese PLA General Hospital Beijing China

Objective allocryptopine （ALL） is an effective alkaloid of Corydalis decumbens （Thunb.） Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current （Ito） and slow delayed rectifier potassium current （IKs）. Methods The monophasic action potential （MAP） technique was used to record the MAP duration of the epicardium （Epi）, myocardium （M） and endocardium （Endo） of the rabbit heart and the whole cell patch clamp was used to record/to and IKs in cardiomyocytes of Epi, M and Endo layers that were isolated from rabbit ventricles. Results The effects of ALL on MAP of Epi, M and Endo layers were disequilibrium. ALL could effectively reduce the transmural dispersion of repolarization （TDR） in rabbit transmural ventricular wall. ALL decreased the current densities of/to and IKs in a voltage and concentration dependent way and narrowed the repolarizing differences among three layers. The analysis of gating kinetics showed ALL accelerated the channel activation ofIto in M layers and partly inhibit the channel openings of/to in Epi, M and Endo cells. On the other hand, ALL mainly slowed channel deactivation of IKs channel in Epi and Endo layers without affecting its activation. Conclusions Our study gives partially explanation about the mechanisms of tmnsmural inhibition of/to and IKs channels by ALL in rabbit myocardium. These findings provide novel perspective regarding the anti-arrhythmogenesis application of ALL in clinical settings.

关键词： allocryptopine Endocardium Epicardium Midcardium Slow delayed rectifier potassium channel Transient outward potassiumcurrent

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Effect of allocryptopine on Late sodium current of atrial myocytes in spontaneously hypertensive rats

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Journal of Geriatric Cardiology 2017年第4期14卷 280-286页

作者： Ying ZHAO Xiao-Ting XIE Yan-Mei SUN Zhong-Qi CAI Ying DONG Chao ZHU Xi CHEN Hong-Lin WU Jian-Cheng ZHANG Yang LI Department of Cardiology Chinese PLA General Hospital Beijing China Provincial Clinical Medicine College of Fujian Medical University Fuzhou Fujian China Cardiovascular Department Chifeng Songshan hospital of the Mongolia lnner Autonomous Region Chifeng China

Objective To explore the effect of allocryptopine （All） on the Late sodium current （INa,Late） of atrial myocytes in spontaneously hyper- tensive rats （SHR）. Method The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto rat （WKY） rats. INa,Late was record by patch-clamp technique and the effect of All on the current was evaluated. Results Comparing with WKY cells, markedly increasing of INa,Late current in SHR myocytes was found from 0.24 ± 0.02 pA/pF of WKY cells to 1.73± 0.04 pA/pF of SHR cells （P 〈 0.01, n = 15）. After treament with 30 μmol/L All; the current densities was reduced to 0.92 ± 0.03 pA/pF. The ratio of INa,Late/INa,peak of WKY and SHR were 0.09% ± 0.01% and 0.71% ± 0.02%, INa, Late/INa,peak of SHR was reduced to 0.37% ± 0.02% by 30 μmol/L All （P 〈 0.01, n = 15）. We also determined the effect of All on the gating mechanism of the INa,Late in the SHR cells. It was found that All decreased the INa,Late by alleviating the inactivation of the channels and increasing the window current of sodium channel. Conclusion Increased INa,Late in SHR atrial myocytes and the prolonged APD were inhibited by All coming from Chinese herb medicine.

关键词： Action potential allocryptopine Atrial myocytes Late sodium current Spontaneously hypertensive rats

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从汇状蓟罌粟分离β—阿洛克立朴託品(β-allocryptopine)

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药学进展 1962年第1期 22-22页

作者：吴知行

汇状薊罂粟(Argemene squarrosa ***)生物硷的含量测定,获得大约1％β—阿洛克立朴托品(β—Allceryptopine),这是较重要的生物硷,此生物硷已经用常用的衍生物并与它的物理的同分異构物α—阿洛克立朴托品,进行过红外光谱的比较鑑定。... 详细信息

汇状薊罂粟(Argemene squarrosa ***)生物硷的含量测定,获得大约1％β—阿洛克立朴托品(β—Allceryptopine),这是较重要的生物硷,此生物硷已经用常用的衍生物并与它的物理的同分異构物α—阿洛克立朴托品,进行过红外光谱的比较鑑定。经药理试验后,征明此生物硷除了已知的抑制心房颤动效能外,并无其它作用。

关键词：生物硷洛克 allocryptopine

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