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Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study

World Journal of Hepatology 2021年第8期13卷 939-948页

作者： Ali Madian Ahmed Eliwa Hytham Abdalla Haitham A Azeem Aly Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineAl-Azhar University-CairoCairo 11754Egypt Department of Chest Diseases Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt Department of Internal Medicine Faculty of MedicineAl-Azhar University-AssiutAssiut 71524Egypt

BACKGROUND Clearly,infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other *** need predictive models to determine patients’prognoses and to improve health care resource allocation during the coronavirus disease 2019(COVID-19)*** treating COVID-19,we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized *** To investigate the association between hepatocellular injury and all-cause inhospital mortality among patients with *** This multicentre study employed a retrospective cohort *** adult patients admitted to Al-Azhar University hospital,Assiut,Egypt and Abo Teeg General hospital,Assiut,Egypt with confirmed COVID-19 from June 1,2020,to July 30,2020 were *** categorized our cohort into three groups of(1)patients with COVID-19 presenting normal aminotransferase levels;(2)patients with COVID-19 presenting one-fold higher aminotransferase levels;and(3)patients with COVID-19 presenting two-fold higher aminotransferase *** analysed the association between elevated aminotransferase levels and all-cause in-hospital *** survival analysis was performed using the Kaplan–Meier method and tested by log-rank *** In total,376 of 419 patients met the inclusion criteria,while 29(8%)patients in our cohort died during the hospital *** median age was 40 years(range:28-56 years),and 51%were males(n=194).At admission,54%of the study cohort had liver *** pattern of liver injury was hepatocellular injury with an aspartate aminotransferase(AST)*** AST levels were independently associated with all-cause in-hospital mortality in the logistic regression analysis.A one-fold increase in serum AST levels among patients with COVID-19 led to an eleven-fold increase in in-hospital mortality(P<0.001).Admission AST levels correlated with C-reactive protein(r=0.2;P<0.003)and serum fer

关键词： COVID-19 Liver injury Aspartate amino transferase all-cause in-hospital mortality Serum ferritin SARS-CoV-2

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