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alkaloids as potential antivirals.A comprehensive review

Natural Products and Bioprospecting 2023年第1期13卷 718-755页

作者： Shah Faisal Syed Lal Badshah Bibi Kubra Abdul-Hamid Emwas Mariusz Jaremko Department of Chemistry Islamia College University PeshawarPeshawar 25120Pakistan Core Labs King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Division of Biological and Environmental Sciences and Engineering(BESE) Smart-Health Initiative(SHI)and Red Sea Research Center(RSRC)King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

alkaloids are a diverse group of natural *** phytochemicals in plants provide them protection against pests,and herbivorous organisms and also control their *** of these alkaloids have a variety of biological effects,and some have even been developed into medications with different medicinal *** review aims to provide a broad overview of the numerous naturally occurring alkaloids(isolated from both terrestrial and aquatic species)along with synthetically produced alkaloid compounds having prominent antiviral *** reviews on this subject have focused on the biological actions of both natural and synthetic alkaloids,but they have not gone into comprehensive detail about their antiviral *** reviewed here several antiviral alkaloids that have been described in the literature in different investigational environments i.e.(in-vivo,in-ovo,in-vitro,and in-silico),and found that these alkaloid compounds have significant antiviral properties against several infectious *** alkaloids repressed and targeted various important stages of viral infection at non-toxic doses while some of the alkaloids reported here also exhibited comparable inhibitory activities to commercially used ***,these anti-viral effects of alkaloids point to a high degree of specificity,implying that they could serve as effective and safe antiviral medicines if further pursued in medicinal and pharmacological investigations.

关键词： alkaloid antivirals Antiviral agents Antiviral phytochemicals In vitro Spread Inhibition

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