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Noteworthy effects of a long-pulse alexandrite laser for treatment of high-risk infantile hemangioma: A case report and literature review

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World Journal of Clinical Cases 2019年第14期7卷 1876-1883页

作者： Wen-Ting Su Ji-Xin Xue You-Hui Ke Medical Cosmetology Department Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou Skin Disease and Plastic Surgery HospitalWenzhou 325000Zhejiang ProvinceChina Department of Hand and Plastic Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND We have previously proved that treatment of thick/deep infantile hemangiomas (IHs) with a long-pulse alexandrite laser was clinically effective and safe. This article aims to investigate the efficiency of long-pulse alexandrite laser use in treating thick and high-risk IHs located in particular anatomic areas and provides some new data on this issue. CASE SUMMARY A two-month-old girl with a thick and high-risk IH covering most of the right labia majora was examined in this study. The infant received four treatment sessions at 4- to 6-wk intervals with a long-pulse alexandrite laser with settings as follows: 3 ms pulse duration, 8 mm spot size, 45 to 50 J/cm2 fluences, and dynamic cooling device (DCD) spray duration of 90 ms with a delay of 80 ms. Following each of the four treatment sessions, the IH showed a remarkable reduction in thickness and size without any sign of relapse. Ten months after the last treatment, the IH had completely regressed without adverse effects. During the laser treatment, no severe side effects were observed;blistering occurred only immediately after treatment and then scabbed over the next day, gradually improving in the following days. CONCLUSION Long-pulse alexandrite laser treatment may be considered one of the first-line noninvasive therapeutic options for the treatment of thick IH.

关键词： alexandrite laser Infantile hemangiomas Treatment Case report

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PROPERTIES OF EXCITED STATES OF Cr^(3+) IN alexandrite CRYSTAL

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Chinese Science Bulletin 1989年第3期34卷 199-202页

作者：徐坚熊光楠徐叙瑢 Changchun Institute of Physics Academia Sinica

Ⅰ. INTRODUCTIONalexandrite is a hopeful laser crystal not only because the sharp R-line shows laser action, as in ruby, but also the vibronic sideband is involved in the lasing of this crystal, in this case the system is of four-levels and is widely tunable （700 nm--800 nm）. We have studied the dynamic properties of the excited states of Cr3+ in BeAl2O4. The relaxation of the system within the excited states reveals the dynamics of the interactions of the ion defects with phonons. As the time of relaxation

关键词： alexandrite (BeAl2O4: Cr3+) luminescence picosecond spectrum.

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Photo-Induced Thermally Stimulated Depolarization Current (TSDC) in Natural and Synthetic alexandrite (BeAl₂O₄:Cr³⁺)

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Materials Sciences and Applications 2016年第12期7卷 881-894页

作者： Neilo Marcos Trindade Ana Regina Blak Elisabeth Mateus Yoshimura Luis Vicente de Andrade Scalvi Rosa Maria Fernandes Scalvi Sã o Paulo Federal Institute S&atilde o Paulo Brazil Institute of Physics University of S&atilde o Paulo S&atilde o Paulo Brazil Department of Physics S&atilde o Paulo State University Bauru Brazil

The investigation of electrical properties in alexandrite (BeAl2O4:Cr3+) in synthetic and natural forms is presented in this paper. alexandrite is a rare and precious mineral that changes color according to the light incident on it. In the synthetic form, it is used technologically as an active laser medium. The electrical characterization was obtained using the Thermally Stimulated Depolarization Current (TSDC) technique, an interesting tool to study the behavior of impurities in insulators. alexandrite presented the electric dipole relaxation phenomenon, both in natural and in synthetic samples. It was possible to observe TSDC bands for the synthetic sample at around 170 K, and at around 175 K for the natural sample. Besides, photo-induced TSDC measurements were performed through the excitement of the samples by using a continuous wave argon laser. In addition, photoluminescence measurements were performed to verify in advance whether the laser light would be absorbed by the sample, and in order to complement the photo-induced TSDC measurements analysis. The results of photo-induced TSDC experiments have contributed to the understanding of the TSDC bands behavior: the results obtained with the technique suggest that there is an effective participation of Cr3+ ions in the formation of TSDC bands because they were more intense when the sample was exposed to the argon laser beam.

关键词： alexandrite Chrysoberyl Thermally Stimulated Depolarization Current (TSDC) Photoluminescence Photo-Induced

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Temperature Dependent Luminescence Spectra of Synthetic and Natural alexandrite (BeAl2O4:Cr3+)

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Materials Sciences and Applications 2011年第4期2卷 284-287页

作者： Neilo Marcos Trindade Américo Tabata Rosa Maria Fernandes Scalvi Luis Vicente de Andrade Scalvi 不详

Results of photoluminescence measurements for natural and synthetic alexandrite (BeAl2O4:Cr3+) are presented, where the samples are excited by the 488 nm line of an Ar+ laser, at different temperatures. The main issue is the analysis of the Cr3+ transition in the chrysoberyl matrix (BeAl2O4), with major technological application as active media for laser action. Results indicate anomalous behavior of Cr33+ transition depending on the measurement temperature. A simple model to explain the phenomena is suggested.

关键词： alexandrite Luminescence Cr3+ Transitions Optical Absorption

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alexandrite激光治疗雀斑近远期疗效观察

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皮肤科学通报 2015年第5期 556-557页

作者：吕蓉陶丁汤亚娥四川省医学科学院·四川省人民医院激光中心

对经Alex激光治疗的172例雀斑患者的近期（术后半年）效果及31例远期（治愈后满5年的患者）效果进行统计分析。结果:术后3;个月复查,172例雀斑患者经1次治疗后治愈165例,占95.9%,2次治愈3例（1.7%）,1次治疗有效但中断治疗4例,总有效率1... 详细信息

对经Alex激光治疗的172例雀斑患者的近期（术后半年）效果及31例远期（治愈后满5年的患者）效果进行统计分析。结果:术后3;个月复查,172例雀斑患者经1次治疗后治愈165例,占95.9%,2次治愈3例（1.7%）,1次治疗有效但中断治疗4例,总有效率100%。远期疗效:经Alex激光治愈后满5年的患者,符合条件随访者87例,回收信息31条;复发18例,复发率

关键词：雀斑患者皮肤色素异常激光治疗 alexandrite 远期疗效

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关于alexandrite译名的探讨

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激光与光电子学进展 1985年第12期 41-41页

作者：马笑山

alexandrite固体可调谐激光晶体问世以来,深受国内外学者重视。用这种晶体材料研制的激光器,不但调谐范围宽,输出功率大,结构紧凑,性能稳定,在室温运转,且其效率随温度升高而增大,在225℃时效率达到极大值。1984年初美国国家科学基金会... 详细信息

alexandrite固体可调谐激光晶体问世以来,深受国内外学者重视。用这种晶体材料研制的激光器,不但调谐范围宽,输出功率大,结构紧凑,性能稳定,在室温运转,且其效率随温度升高而增大,在225℃时效率达到极大值。1984年初美国国家科学基金会在讨论固体激光器时,认为有可能由alexandrite激光器代替Nd:YAG激光器。有关这种晶体的研究及相关材料的研究已发表不少文章,也有不少译文介绍国外情况,但这种材料的译名却极不统一。给工作带来不便,故有正名的必要。

关键词：译名晶体激光器光激射器电子器件 alexandrite 铍矿物金绿宝石铍尖晶石掺铬

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Effects of Q-Switched Laser Treatments on Acquired Bilateral Nevus of Ota-Like Macules: A Retrospective Comparative Study

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International Journal of Dermatology and Venereology 2019年第2期2卷 70-76页

作者： Rong Zeng Yu-Zhen Liu Tong Lin Li-Fang Guo Yi-Ping Ge Meng-Li Zhang Yin Yang Qiu-Ju Wu Yu-Le Wu Min Li Cosmetic Lasers Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Q-switched lasers,including 1064-nm Nd:YAG nansecond laser (QSNYL),755-nm alexandrite nanosecond laser (QSAL),and 694-nm nanosecond ruby laser (QSRL),are clinically available for the treatment of acquired bilateral nevus of Ota-like macules (ABNOM).However,no reliable evidence from large-scale comparative studies identifies which type of laser works *** study aims to determine the differences in the effectiveness,complications,and risk factors of QSNYL,QSAL,and QSRL in the treatment of ABNOM,further to provide evidence for clinician to make optimal choice according to the condition of ***:We collected the data from 685 ABNOM patients,including clinical features,medical treatments,and follow-up,since 1999 to *** Kruskal-Wallis test was used to compare therapeutic differences between the three *** risk factors were analyzed using univariate analysis (x2 test) and multivariate logistic regression ***:The overall treatment efficiency of the QSNYL group (52.5%) and QSAL group (51.9%) was higher than that of the QSRL group (39.5%) (x2 =17.468,P < 0.001).The onset time of the QSRL and QSAL groups was shorter than that of the QSNYL *** factors influencing efficacy in the QSNYL group were age at first treatment,number of treatments,coexistence with melesma,and the presence of hyperpigmentation;in the QSAL group was the number of treatments;and in the QSRL group was the number of treatments and *** prevalence of hyperpigrnentation in the QSNYL group (30.5%) and the QSAL group (27.5%) was lower than that of the QSRL group (47.3%) (X2=6.576,P<0.001).Concluslon:The QSNYL,QSAL,and QSRL are all effective and safe treatments for *** the overall efficacy,duration of treatment,side effects,and risk factors,the QSAL is an optimal choice for ABNOM treatment.

关键词： acquired bilateral nevus of Ota-like macules Q-switched laser Nd∶YAG laser alexandrite laser ruby laser retrospective comparative study

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