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Correlation analysis of mental health conditions and personality of patients with alcohol addiction

World Journal of Psychiatry 2023年第11期13卷 893-902页

作者： Yu Liu Yang Liu Jun Cheng Liang-Jun Pang Xu-Lai Zhang Department of Material Dependence Affiliated Psychological Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Material Dependence Hefei Fourth People’s HospitalHefei 230022Anhui ProvinceChina Department of Geriatric Psychology Affiliated Psychological Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND alcohol addiction,or alcohol dependence,refers to a psychological state of strong craving for alcohol caused by drinking when both the drinking times and alcohol consumption reach a certain *** addiction can cause irreversible damage,leading to mental illness or mental disorders,negative changes in their original personality,and a tendency to safety incidents such as committing suicide or violent attacks on *** attention needs to be given to the mental health of alcohol addicts,which could reflect their abnormal personality ***,only a few papers on this issue have been reported in *** To investigate the correlation between mental health and personality in patients with alcohol *** In this single-center observational study,we selected 80 patients with alcohol addiction as the research subjects,according to the criteria of the K10 scale to evaluate the mental health of patients with alcohol addiction,and divided these patients into four groups based on the evaluation results:Good,average,relatively poor and *** then analyzed the correlation between mental health conditions and personality characteristics from these four groups of *** The average score of the K10 scale(Kessler 10 Simple Psychological Status Assessment Scale)in 80 patients with alcohol addiction was 25.45 points,the median score was 25 points,the highest score was 50 points,and the lowest score was 11 ***'s analysis showed that the K10 score was positively correlated with the scores of these two subscales,such as the P-subscale and the N-subscale(P0.05).CONCLUSION The mental health conditions of patients with alcohol addiction are positively correlated with their personality characteristics.

关键词： alcohol addiction Mental health Personality characteristics Public health Patients Correlational analysis

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Aberrant synaptic plasticity and alcohol addiction

Aberrant synaptic plasticity and alcohol addiction

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中国毒理学会第九次全国毒理学大会

作者： WANG Xiao-jie CHENG Yi-feng EmilyRoltschHellard WANG Jun MA Teng-fei School of Pharmacy Nanjing Medical University

addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation（LTP） and depression（LTD）. However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. We report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. Blockade of this LTP by NMDAreceptor inhibition unmasked an endocannabinoid-dependent LTD. In vivo application of the LTP-inducing protocol caused a long-lasting increase in alcohol-seeking behavior, while the LTD protocol decreased this behavior. We further identified that optogenetic LTP and LTD induction at cortical inputs onto striatal dopamine D1 receptor-expressing neurons controlled these behavioral changes. Our results demonstrate a causal link between synaptic plasticity and alcohol-seeking behavior and suggest that modulation of this plasticity may inspire a therapeutic strategy for addiction.

关键词： alcohol addiction LTP LTD NMDAR Neural Circuits

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