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Association of smoking, alcohol drinking and dietary factors with esophageal cancer in high- and low-risk areas of Jiangsu Province, China

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World Journal of Gastroenterology 2006年第11期12卷 1686-1693页

作者： Ming Wu Jin-Kou Zhao Xiao-Shu Hu Pei-Hua Wang Yu Qin Yin-Chang Lu Jie Yang Ai-Min Liu De-Lin Wu Zuo-Feng Zhang Kok J Frans Pieter van't Veer Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009 Jiangsu ProvinceChina Dafeng Center for Disease Control and Prevention Dafeng 224100 Jiangsu Province China Ganyu Center for Disease Control and Prevention Ganyu 222100 Jiangsu Province China Department of Epidemiology UCLA School of PublicHealth Los Angeles California United States Pieter van't Veer Division of Human Nutrition Wageningen University Wageningen 6700 EV the Netherlands Supported by Jiangsu Provincial Health Department No. RC 2003090

AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a population-based casecontrol study has been conducted simultaneously in lowrisk （Ganyu County） and high-risk （Dafeng County） areas of Jiangsu Province, China. Using identical protocols and pre-tested standardized questionnaire, following written informed consent, eligible subjects were inquired about their detail information on potential determinants of EC, including demographic information, socio-economic status, living conditions, disease history, family cancer history, smoking, alcohol drinking, dietary habits, frequency, amount of food intake, etc. Conditional logistic regression with maximum likelihood estimation was used to obtain Odds ratio （OR） and 95 % confidence interval （95% CI）, after adjustment for potential confounders. RESULTS： In the preliminary analysis of the ongoing study, we recruited 291 pairs of cases and controls in Dafeng and 240 pairs of cases and controls in Ganyu, respectively. In both low-risk and high-risk areas, EC was inversely associated with socio-economic status, such as level of education, past economic status and body mass index. However, this disease was more frequent among those who had a family history of cancer or encountered misfortune in the past 10 years. EC was also more frequent among smokers, alcohol drinkers and fast eaters. Furthermore, there was a geographic variation of the associations between smoking, alcohol drinking and EC risk despite the similar prevalence of these risk factors in both low-risk and high-risk areas. The dose-response relationship of smoking and smoking related variables, such as age of the first smoking, duration and amount were apparent only in high-risk areas. On the contrary, a dose-response relationship on the effect of alcohol drinking on EC was observed only in low-risk areas. CONCL

关键词： Esophageal cacner Case-control study Smoking alcohol drinking Dietary factors

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CYP2E1 RsaⅠpolymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking

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World Journal of Gastroenterology 2007年第43期13卷 5725-5730页

作者： Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Min-Bin Chen Yan-Ting Liu Jian-Hua Ding Haruhiko Sugimura Jia Cao Nobuyuki Hamajima Kazuo Tajima Division of Epidemiology Jiangsu ProvinceInstitute of Cancer Research Nanjing 210009 Jiangsu ProvinceChina Department of International Island andCommunity Medicine Kagoshima University Graduate Schoolof Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima890-8544 Japan Molecular Toxicology Laboratory Third MilitaryMedical Universit School of Public Healthy Chongqing 400038China Department of Preventive MedicineBiostatistics and Medical Decision Making Nagoya UniversitySchool of Medicine Nagoya 466-8550 Japan Division of Epidemiology and Prevention AichiCancer Center Research Institute Nagoya 464-8681 Japan

AIM： To investigate associations between the Rsa I polymorphism of CYP2E1 and risk of colorectal cancer. METHODS： A case-control study was conducted with 315 colorectal cancer cases （105 colon, 210 rectal） and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa I. Information on smoking and alcohol drinking was collected using a questionnaire. Odds ratios （ORs） were estimated with an unconditional logistic model. RESULTS： The proportional distribution of the CYP2E1 Rsa I c1/c1, c1/c2 and c2/c2 genotypes were 61.4%, 35.6% and 3.0% in controls, 60.6%, 33.7% and 5.8% in colon cancer cases, and 58.4%, 34.0% and 7.7% in rectal cancer cases, respectively. A significant differencewas noted between controls and rectal cancer cases （P = 0.029）, the c2/c2 genotype being associated with elevated OR （adjusted age, sex and status of the smoking and alcohol drinking） for rectal cancer （1.64, 95% CI, 1.12-2.41, vs cl allele carriers）, but not for colon cancer. In interaction analysis between the CYP2E1 Rsa I genotype and smoking and drinking habits, we found a significant cooperative action between the c2/c2 genotype and alcohol drinking in the sex-, age-adjusted ORs for both colon （4.74, 95% CI, 1.10-20.40） and rectal （5.75, 95% CI, 1.65-20.05） cancers. Among nonsmokers, the CYP2E1 Rsa I c2/c2 genotype was also associated with elevated ORs in the two sites （1.95, 95% CI, 0.99-3.86 and 2.30, 95% CI, 1.32-3.99）. CONCLUSION： The results of the present study suggest that the CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general.

关键词： CYP 2E1 Gene polymorphism Smoking alcohol drinking Colorectal cancer

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Cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwan Residents women

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World Journal of Gastroenterology 2010年第12期16卷 1518-1521页

作者： I-Chen Wu Deng-Chyang Wu Hung-Ju Su Hui-Jen Tsai Chien-Yu Lu Jang-Ming Lee Ming-Tsang Wu Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Faculty of Medicine College of MedicineKaohsiung Medical University Biomedical Engineering Research Laboratories Industrial Technology Research Institute Division of Hematology and Oncology Department of Internal MedicineKaohsiung Medical University Hospital Department of Surgery National Taiwan University Hospital Department of Family Medicine Kaohsiung Medical University Hospital Graduate Institute of Occupational Safety & Health Kaohsiung Medical University

AIM:To investigate the etiology of esophageal cancer among Taiwan Residents ***:This is a multi-center,hospital-based,case-control *** patients consisted of women who were newly diagnosed and pathology-proven to have esophageal squamous cell carcinoma(ESCC) from three large medical centers(one from Northern and two from Southern Taiwan,respectively)between August 2000 and December *** ESCC patient was matched with 4 healthy women based on age(within 3 years)and hospital of origin,from the Department of Preventive Medicine in each hospital.A total of 51 case patients and 204 controls,all women,were ***:Frequencies of smokers and drinkers among ESCC patients were 19.6%and 21.6%,respectively,which were significantly higher than smokers(4.4%) and drinkers(4.4%)among controls(OR=4.07,95%CI:1.36-12.16,P=0.01;OR=3.55,95%CI:1.03-12.27,P=0.04).Women who drank an amount of alcohol more than 158 g per week had a 20.58-fold greater risk(95%CI:1.72-245.62,P=0.02)of ESCC than those who never drank alcohol after adjusting for other covariates,although the sample size was ***:Cigarette smoking and alcohol drinking,especially heavy drinking,are the major risks for developing ESCC in Taiwan Residents women.

关键词： Esophageal squamous cell carcinoma Taiwan Residents women Cigarette smoking alcohol drinking

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alcohol drinking induced pain in humans caused by the SCN11A and ALDH2 mutations

Alcohol drinking induced pain in humans caused by the SCN11A...

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2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Luoyao Yang Lulu Li Tingbin Ma Xiaoliu Shi Jing Yu Liu Key Laboratory of Molecular Biophysics of the Ministry of Education School of Life Science and TechnologyHuazhong University of Science and Technology Department of Medical Genetics The Second Xiangya HospitalCentral South University

The mutations in Nav1.9 encoded by the gene SCN11 A has been associated with different peripheral pain syndromes. Identification and functional studies of Nav1.9 mutations are necessary to explain the pathogenesis and revealed the relationship between the clinical characteristics and mutation spectrum of Nav1.9 channelopathy. In this study, we collected one Chinese episodic pain syndrome families and identified Nav1.9 mutation（***222 Ser） that linked with familial episodic pain. The pain symptom of proband could induce by alcohol ingestion and we confirmed ALDH2 gene polymorphism（***504 Lys） that could result in the vast accumulation of acetaldehyde in body. We also verified the similar new symptom in two previously reported episodic pain families with Nav1.9 mutations（***225 Cys and ***808 Gly）. To address the pathogenicity of Nav1.9 mutation and new clinical symptom, we introduced orthologous mutation（***796 Gly in mouse） into the mouse by homologous recombination. As could be expected, Scn11 a A796 G/A796 G mice showed increased sensitivity to mechanical, thermal and cold stimulus. Moreover, the Scn11 a A796 G/A796 G mice showed the hypersensitivity for aldehydes and formalin, which explained that alcohol intake, induced the pain in the proband. Besides, we showed the alteration induced hyperexcitability of DRG neurons in Scn11 a A796 G/A796 G mice. These results showed that Scn11 a A796 G/A796 G mice recapitulated many clinical features of human and Nav1.9 channel play a crucial role in inflammation pain state.

关键词： alcohol drinking pain SCN11A ALDH2

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alcohol Cessation in Late Life is Associated with Lower Risk of Cognitive Impairment among the Older Adults in China

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Biomedical and Environmental Sciences 2021年第7期34卷 509-519页

作者： ZHANG Xiao Chang GAO Xiang LYU Yue Bin ZHOU Jin Hui WEI Yuan YIN Zhao Xue MA Ji Xiang MAO Chen SHI Xiao Ming National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China Division of Non-communicable Disease and Ageing Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Nutritional Epidemiology Lab Pennsylvania State UniversityPhiladelphia 16801PAUSA Center for Disease Control and Prevention of Shandong Province Jinan 250014ShandongChina Division of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective Evidence regarding alcohol consumption and cognitive impairment is *** cessation of drinking alcohol by non-dependent drinkers alters the risk of cognitive impairment remains *** study prospectively evaluated the potential association between the history of lifetime alcohol cessation and risk of cognitive *** This study included 15,758 participants age 65 years or older,selected from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)that covered 23 provinces in *** alcohol use status,duration of alcohol cessation,and alcohol consumption before abstinence were self-reported by participants;cognitive function was evaluated using Mini-mental State Examination(MMSE).Causespecific hazard models and restricted cubic splines were applied to estimate the effect of alcohol use on cognitive *** Among the 15,758 participants,mean(±SD)age was 82.8 years(±11.9 years),and 7,199(45.7%)were *** a mean of 3.9 years of follow-up,3,404 cases were identified as cognitive *** with current drinkers,alcohol cessation of five to nine years[adjusted HR,0.79(95%CI:0.66-0.96)]and more than nine years[adjusted HR,0.82(95%CI:0.69-0.98)]were associated with lower risk of cognitive *** A longer duration of alcohol cessation was associated with a lower risk of cognitive impairment assessed by *** cessation is never late for older adults to prevent cognitive impairment.

关键词： Cognition alcohol abstinence alcohol drinking Epidemiology Aging

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Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

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World Journal of Gastroenterology 2008年第32期14卷 5078-5083页

作者： Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Xiao-Mei Zhang Hai-Xia Cao Jian-Hua Ding Yan-Ting Liu Su-Ping Li Jia Cao Keitaro Matsuo Nobuyuki Hamajima Kazuo Tajima Division of Epidemiology Jiangsu Provincial Institute of Cancer Research 42 Baiziting Nanjing 210009 Jiangsu Province China Department of International Island and Community Medicine Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima 890-8544 Japan Hygiene Toxicology Department Third Military Medical University Preventive medicine college 30 Gaotanyan Avenue Shapingba District Chongqing 400038 China Division of Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya 464-8681 Japan Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University School of Medicine Nagoya 466-8550 Japan

AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males. METHODS: A case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A)genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC). Information on smoking and drinking was collected and odds ratio (OR) was estimated. RESULTS: The ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Signif icant interactions between ADH2, ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a signif icantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ADH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with the ALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele. CONCLUSION: Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also signifi cant gene-gene and gene- environment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.

关键词： alcohol dehydrogenase 2 Aldehydede hydrogenase 2 Gene polymorphisms alcohol drinking Colorectal cancer

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Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males

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World Journal of Gastroenterology 2009年第19期15卷 2395-2400页

作者： Jian-Hua Ding Su-Ping Li Hai-Xia Cao Jian-Zhong Wu Chang-Ming Gao Ping Su Yan-Ting Liu Jian-Nong Zhou Jun Chang Gen-Hong Yao Division of Epidemiology Jiangsu Provincial Institute of Cancer Research 42 Baiziting Nanjing 210009 Jiangsu Province China Taixing Center for Disease Prevention and Control Taixing 225400 Jiangsu Province China

AIM： To evaluate the impact of alcohol dehydrogenase-2 （ADH2） and aldehyde dehydrogenase-2 （ALDH2） polymorphisms on esophageal cancer susceptibility in Southeast Chinese ***： Two hundred and twenty-one esophageal cancer patients and 292 healthy controls from Taixing city in Jiangsu Province were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase chain reaction and denaturing high-performance liquid chromatography. Unconditional logistic regression was used to calculate the odds ratios （OR） and 95% confidence interval （CI）.RESULTS： The ADH G allele carriers were more susceptible to esophageal cancer, but no association was found between ADH2 genotypes and risk of esophageal cancer when disregarding alcohol drinking status. Regardless of ADH2 genotype, ALDH2G/A or A/A carriers had significantly increased risk of developing esophageal cancer, with homozygous individuals showing higher esophageal cancer risk than those who were heterozygous. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk; the OR was 3.05 （95% CI： 2.49-6.25）. Compared with non-drinkers carrying both ALDH2 G/G and ADH2 A/A, drinkers carrying both ALDH2 A allele and ADH2 G allele showed a significantly higher risk of developing esophageal cancer （OR = 8.36, 95% CI： 2.98-23.46）.CONCLUSION： Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males. ALDH2 A allele significantly increases the risk of esophageal cancer development especially in alcohol drinkers. alcohol drinkers carrying both ADH2 G allele and ALDH2 A allele have a higher risk of developing esophageal cancer.

关键词： alcohol dehydrogenase-2 Aldehyde dehydrogenase-2 Gene polymorphisms alcohol drinking Esophageal cancer

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Acute esophageal necrosis caused by alcohol abuse

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World Journal of Gastroenterology 2005年第35期11卷 5568-5570页

作者： Tetsu Endo Juichi Sakamoto Ken Sato Miyako Takimoto Koji Shimaya Tatsuya Mikami Akihiro Munakata Tadashi Shimoyama Shinsaku Fukuda First Department of Internal Medicine Hirosaki University School of Medicine 5 Zaifucho Hirosaki Aomori 036-8562 Japan

Acute esophageal necrosis (AEN) is extremely rare and the pathogenesis of this is still unknown. We report a case of AEN caused by alcohol abuse. In our case, the main pathogenesis could be accounted for low systemic perfusion caused by severe alcoholic lactic acidosis. After the healing of AEN, balloon dilatation was effective to manage the stricture.

关键词： Esophagus Lactic acidosis alcohol drinking Balloon dilatation

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Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis

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World Journal of Clinical Cases 2022年第1期10卷 136-142页

作者： Ye Yan Jian-Sheng Wu Shuang Pan Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The pathogenesis of colonic diverticulosis is not well ***,only a few studies on colonic diverticulosis have been reported in China's *** To evaluate the prevalence of and risk factors for asymptomatic colorectal diverticulosis in Eastern *** From August 2016 to July 2020,6180 asymptomatic individuals were enrolled in this cross-sectional *** individuals had undergone physical examinations,laboratory testing,and *** regarding the baseline characteristics and their general health status were obtained through *** The prevalence of colonic diverticulosis was 7.3%(449/6180).Colonic diverticulosis was detected predominantly on the right side of the colon(88.4%).Logistic regression analysis revealed that an age≥60 years(adjusted odds ratio[OR]2.149,95%confidence interval[CI]1.511-3.057,Palcohol intake(adjusted OR:1.518,95%CI:1.213-1.901,Palcohol intake,obesity,and other metabolic-related factors,such as hypertension,hypertriglyceridemia,and hyperuricemia,were independent risk factors for colonic *** the true prevalence of colonic diverticulosis and its associated risk factors will aid in its prevention and treatment.

关键词： Aged alcohol drinking Colonic diverticulosis Hypertension Obesity

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alcohol consumption for simulated driving performance： A systematic review

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Chinese Journal of Traumatology 2017年第3期20卷 166-172页

作者： Mohammad Saeid Rezaee-Zavareh Payman Salamati Mahdi Ramezani-Binabaj Mina Saeidnejad Mansoureh Rousta Farhad Shokraneh Vafa Rahimi-Movaghar Students' Research Committee Baqiyatallah University of Medical Science Tehran lran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran lran Islamic Azad University Tehran Medical Branch Tehran lran Students' Scientific Research Center Tehran University of Medical Sciences Tehran lran Research Center for Pharmaceutical Nanotechnology Iranian Center for Evidence-based Medicine Tabriz University of Medical Sciences Tabriz lran

Purpose： alcohol consumption can lead to risky driving and increase the frequency of traffic accidents, injuries and mortalities. The main purpose of our study was to compare simulated driving performance between two groups of drivers, one consumed alcohol and the other not consumed, using a systematic review. Methods： In this systematic review, electronic resources and databases including Medline via Ovid SP, EMBASE via Ovid SP, PsyclNFO via Ovid 5P, PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature （CINHAL） via EBSCOhost were comprehensively and systematically searched. The randomized controlled clinical trials that compared simulated driving performance between two groups of drivers, one consumed alcohol and the other not consumed, were included. Lane position standard deviation （LPSD）, mean of lane position deviation （MLPD）, speed, mean of speed deviation （MSD）, standard deviation of speed deviation （SDSD）, number of accidents （NA） and line crossing （LC） were considered as the main parameters evaluating outcomes. After title and abstract screening, the articles were enrolled for data extraction and they were evaluated for risk of biases. Results： Thirteen papers were included in our qualitative synthesis. All included papers were classified as high risk of biases. alcohol consumption mostly deteriorated the following performance outcomes in descending order： SDSD, LPSD, speed, MLPD, LC and NA. Our systematic review had troublesome heterogeneity. Conclusion： alcohol consumption may decrease simulated driving performance in alcohol consumed people compared with non-alcohol consumed people via changes in SDSD, LPSD, speed, MLPD, LC and NA. More well-designed randomized controlled clinical trials are recommended.

关键词： alcohol abstinence alcohol-related disorders alcohol drinking Automobile driving Computer simulation

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