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Chinese Journal of Integrative Medicine 2015年第4期21卷 307-311页

作者： Jin-Seong Lee Sung-Gon Kim Taek-Geun Jung Woo Young Jung Seong-Yeon Kim Department of Psychiatry Pusan National University Yangsan Hospital Biomedical Research Institute Pusan National University Hospital Jang-Cheon Korean Medicine Clinic Division of Management Information Science(S-YK) Dong-A University

Objective： To examine the effect of acupuncture on Zhubin （KI9） in reducing alcohol craving in alcohol-dependent patients. Methods： Twenty male alcohol-dependent patients were randomly assigned to two groups, a treatment group （10 cases, age 43.0 ± 6.8 years） and a placebo group （10 cases, age 44.5 ± 7.9 years）. The treatment group was treated with real needle acupuncture on Zhubin （KI9） twice a week for 4 weeks, and the control group was treated with placebo needle acupuncture. Both groups were given acupuncture treatment using Park Sham Device （PSD）. alcohol craving was measured by the Visual Analogue Scale （VAS） before treatment to establish a baseline, and after 1, 2, and 4 weeks of treatment. Repeated measures ANOVA was used to determine the main and interaction effects of time and on the outcome measure （VAS）. Results： There was a significant effect of time on VAS score （dr=3, F=13.3, P〈0.01）. Main effect of group on VAS score was significant （df=1, F=10.9, P〈0.01） and the time × group interaction was also significant （df=3, F=4.7, P〈0.01）. Conclusions： Real-needle acupuncture therapy on Zhubin （KI9） showed effectiveness in reducing alcohol craving. These results strongly suggest the usefulness of acupuncture therapy on Zhubin （KI9） in preventing a relapse in alcohol dependent patients.

关键词： alcohol craving alcohol dependence acupuncture Zhubin (KI9)

Genome-wide association study knowledge-driven pathway analysis of alcohol dependence implicates the calcium signaling pathway

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Chinese Medical Journal 2014年第12期127卷 2229-2235页

作者： Li Danni Li Jinming Guo Yanfang Institute of Bioinformatics School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdong 510515China

Background alcohol dependence （AD） is a serious and common public health *** identification of genes that contribute to the AD variation will improve our understanding of the genetic mechanism underlying this complex *** genome-wide association studies （GWAS） and candidate gene genetic association studies identified individual genes as candidates for alcohol phenotypes,but efforts to generate an integrated view of accumulative genetic variants and pathways under alcohol drinking are *** We applied enrichment gene set analysis to existing genetic association results to identify pertinent pathways to AD in this study.A total of 1 438 SNPs （P ＜1.0×10-3） associated to alcohol drinking related traits have been collected from 31 studies （10 candidate gene association studies,19 GWAS of SNPs,and 2 GWAS of copy number variants）.Results Among all of the KEGG pathways,the calcium signaling pathway （hsa04020） showed the most significant enrichment of associations （21 genes） to alcohol consumption phenotypes （P=5.4×10-5）.Furthermore,the calcium signaling pathway is the only pathway that turned out to be significant after multiple test adjustments,achieving Bonferroni P value of 0.8×10-3 and FDR value of 0.6×10-2,***,the calcium signaling pathway was previously found to be essential to regulate brain function,and genes in this pathway link to a depressive effect of alcohol consumption on the *** Our findings,together with previous biological evidence,suggest the importance of gene polymorphisms of calcium signaling pathway to AD ***,further investigations are warranted to uncover the role of this pathway in AD and related traits.

关键词： alcohol dependence genome-wide association pathway

Escitalopram with or without combined electroacupuncture on protracted alcohol withdrawal symptoms(PAWS)among male inpatients with alcohol dependence

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World Journal of Acupuncture-Moxibustion 2020年第2期30卷 90-96页

作者： Fei-yi ZHAO Yan XU Li-ping YUE Fang-lei CHEN Zhe-yuan ZHANG Hua-ling SONG Hong XU Guo-hua WANG Qiang-qiang FU Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Haiyan People’s Hospital Haiyan 314300Zhejiang ProvinceChina College of Public Health Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200071China Research Department Yangpu HospitalTongji University School of MedicineShanghai 200090China

Objective:This study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture(EA)among male inpatients with a diagnosis of alcohol dependence and comorbid protracted alcohol withdrawal symptoms(PAWS).Methods:A total of 62 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to an escitalopram with real-EA group(realEA group,patients=31)and an escitalopram with sham-EA group(sham-EA group,patients=31),*** addition to the oral administration of escitalopram for total four weeks,patients in each group received corresponding EA treatment five days per week and two days off for consecutive four *** serum homocysteine(Hcy)test and electrophysiological tests,including event-related potentials(ERPs)and exploratory eye movement(EEM)were performed at pre-and ***,the global scores of Penn alcohol Craving Scale(PACS),17-items Hamilton Depression Rating Scale(HAMD-17),and Hamilton Anxiety Scale(HAMA)were used for assessing the subjective emotion experience of patients,***,adverse effects were monitored and ***:After four-week treatment,the global scores of PACS and HAMD-17 declined significantly in both groups(both P0.05).According to the parameters of ERPs,significant declines for N2PL,P3PL,and P3amp were observed in both two groups(all P<0.05),and the decreases for P3PL and P3amp in the real-EA group was much superior to that in the sham-EA group(both P<0.05).According to the parameters of EEM,significant increase for NEF was observed only in the real-EA group(P<0.05).Besides,there was a dramatic decline for serum Hcy level only in the real-EA group(P<0.05).One

关键词： alcohol dependence Protracted alcohol withdrawal symptoms(PAWS) Escitalopram Electroacupuncture

Advances in the prediction of biological markers of alcohol dependence relapse

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Journal of Translational Neuroscience 2022年第4期7卷 1-6页

作者： Yinhang Li Tiantian Jiang Tiankai Jiang Yuhang Liang Li Wu Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China Department of alcohol and Drug dependence The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

alcohol dependence is a chronic and re-lapsing disease that causes mental and organ damage due to long-term heavy drinking,which has serious adverse effccts on individuals and *** studics have shown that even after inpatient treatment,the relapse rate of alcohol-dependent patients can be as high as 60%-70%within 3 months after ***,the mecha-nisms associated with relapse to drinking in alcohol-dependent patients are still *** most of the studies reported in the past have been about the relationship between psychosocial factors and relapse to drinking,while few studies have examined the relationship between bi-ological indicators and relapse to ***,in this paper,we summarize the recent literature to explore the biological markers related to alcohol dependence relapse and discuss the progress of research on relapse pre-diction,in order to provide reference and help to reduce the relapse rate and improve the quality of life of patients.

关键词： alcohol dependence relapse biologi-cal marker

alcohol use disorder and liver injury related to the COVID-19 pandemic

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World Journal of Hepatology 2022年第10期14卷 1875-1883页

作者： Giuseppe Marano Gianandrea Traversi Eleonora Gaetani Roberto Pola Angelo Emilio Claro Marianna Mazza Department of Geriatrics Neuroscience and OrthopedicsFondazione Policlinico Universitario A.Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Dipartimento di Medicina di Laboratorio UOSD Genetica MedicaOspedale Generale“San Giovanni Calibita”FatebenefratelliRome 00186Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario A.Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Division of Internal Medicine Fondazione Policlinico Universitario A.Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

alcohol use disorder is a complex and heterogeneous phenomenon that can be studied from several points of view by focusing on its different *** is a hepatotoxin whose metabolism creates profound alterations within the *** liver is the central organ in the metabolism of alcohol,a process that also involves other organs and tissues such as the brain,heart and muscles,but the most relevant organ is the *** anatomopathological alterations in the liver associated with the prolonged use of alcohol range from the simple accumulation of neutral fats in the hepatocytes,to cirrhosis and hepatocellular *** abuse frequently leads to liver disease such as steatosis,steatohepatitis,fibrosis,cirrhosis,and *** the spread of coronavirus disease 2019(COVID-19),there was an increase in alcohol consumption,probably linked to the months of lockdown and smart *** is known that social isolation leads to a considerable increase in stress,and it is also recognized that high levels of stress can result in an increase in alcohol *** patients or subjects with liver cancer are immunocompromised,so they may be more exposed to COVID-19 infection with a worse *** review focuses on the fact that the COVID-19 pandemic has made the emergence of alcohol-induced liver damage a major medical and social problem.

关键词： alcohol use disorder alcoholic liver disease Liver injury COVID-19 alcohol abuse alcohol dependence

ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior

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Chinese Medical Journal 2012年第6期125卷 1127-1134页

作者： CHEN Xiang-ding XIONG Dong-hai YANG Tie-lin PEI Yu-fang GUO Yan-fang LI Jian YANG Fang PAN Feng TAN Li-jun YAN Han LIU Xiao-gang LEI Shu-feng LI Xi NING Ling-ling ZHU Xue-zhen Shawn Levy Henry R. Kranzler Lindsay A. Farrer Joel Gelernter Robert R. Recker DENG Hong-wen Laboratory of Molecular and Statistical Genetics Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College of Life Sciences Hunan Institute of Biology Hunan Normal University Changsha Hunan 410081 China Departments of Orthopedic Surgery and Basic Medical Sciences University of Missouri-Kansas City Kansas City MO 64108 USA Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics School of Life Science and Technology Xi＇an Jiaotong University Xi＇an Shannxi 710049 China Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN 37232 USA University of Connecticut Health Center Farmington CT 06030 USA Boston University School of Medicine Boston MA 02118 USA Department of Psychiatry Yale University School of Medicine West Haven CT 06516 USA Osteoporosis research Center Creighton University Omaha NE 68131 USA Systematic Biomedicine Research Center University of Shanghai for Science and Technology Shanghai 200093 China

Background alcohol dependence （AD） is a complex disorder characterized by impaired control over drinking. It is determined by both genetic and environmental factors. The recent approach of genome-wide association study （GWAS） is a powerful tool for identifying complex disease-associated susceptibility alleles, however, a few GWASs have been conducted for AD, and their results are largely inconsistent. The present study aimed to screen the loci associated with alcohol-related phenotypes using GWAS technology. Methods A genome-wide association study with the behavior of regular alcohol drinking and alcohol consumption was performed to identify susceptibility genes associated with AD, using the Affymetrix 500K SNP array in an initial sample consisting of 904 unrelated Caucasian subjects. Then, the initial results in GWAS were replicated in three independent samples： 1972 Caucasians in 593 nuclear families, 761 unrelated Caucasian subjects, and 2955 unrelated Chinese Hans. Results Several genes were associated with the alcohol-related phenotypes at the genome-wide significance level, with the ankyrin repeat domain 7 gene （ANKRDT） showing the strongest statistical evidence for regular alcohol drinking and suggestive statistical evidence for alcohol consumption. In addition, certain haplotypes within the ANKRD7 and cytokine-likel （CYTL 1） genes were significantly associated with regular drinking behavior, such as one ANKRD7 block composed of the SNPs rs6466686-rs4295599-rs12531066 （P = 6.51×10^-8）. The association of alcohol consumption was successfully replicated with rs4295599 in ANKRD7 gene in independent Caucasian nuclear families and independent unrelated Chinese Hans, and with rs16836497 in CYTL1 gene in independent unrelated Caucasians. Meta-analyses based on both the GWAS and replication samples further supported the observed significant associations between the ANKRDTor CYTL1 gene and alcohol consumption. Conclusion The evidence suggests that ANKRD7 and CYTL 1 ge

关键词： alcohol dependence ANKRD7 CYTL1 genome-wide association study

Pilot Study of Problem Gambling in Specialized Substance Use Disorder Treatment—High Lifetime Prevalence of Problem Gambling in Opioid Maintenance Treatment Patients

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Open Journal of Psychiatry 2018年第3期8卷 233-243页

作者： Anders Hakansson Johanna Ek Department of Clinical Sciences Lund Lund UniversityLundSweden

Problem gambling is over-represented in patients treated for substance use disorders, but substance-specific prevalence of problem gambling is rarely reported. In specialized addiction treatment facilities for opioid maintenance treatment and for alcohol and prescription drug dependence, respectively, 129 patients were screened for problem gambling using the NODS-CLiP. The lifetime prevalence of problem gambling was markedly higher in opioid maintenance treatment (61 percent) than in alcohol and prescription drug dependence treatment (11 percent, p dependence.

关键词： Substance Use Disorder Problem Gambling Gambling Disorder Pathological Gambling Comorbidity Opioid Maintenance Treatment alcohol dependence

A Clinical Study:Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy on Cognitive Impairment in alcohol-Dependent Patients

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牡丹江医学院学报 2022年第4期43卷 1-5,28页

作者： Xiao-He FAN Wei-Bian YANG Cheng-Ji WU Dan SUN Chang-Hao YIN Hong-Xuan WANG Ying PENG Yan-Zhong GUAN Xiao-Feng ZHU Mudanjiang Medical University Mudanjiang 157011China Hongqi Hospital Affiliated to Mudanjiang Medical University Mudanjiang 157011China The First Affiliated Hospital of Jiamusi University Jiamusi 154007China Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangzhou 510120China Collaborative Innovation Center of Development and Application of Northern Medical Herbs Mudanjiang 157011China

Objective To observe the effects of repetitive transcranial magnetic stimulation(rTMS)and cognitive behavioral therapy(CBT)on cognitive function in alcohol-dependent *** Data from 285 alcohol-dependent patients were collected from Mudanjiang Medical University and Sun Yat-sen Memorial Hospital at Sun Yat-sen University between 2019 and *** patients were divided into groups depending on alcohol abstinence and *** were 43 patients in the alcohol consumption(AC)*** patients in the abstinence group were randomly assigned to treatment regimens with different combinations of rTMS and CBT using the Elton *** were 49 patients in the TB+C0 group,36 in the TB+C1 group,44 in the TL+C0 group,36 in the TL+C1 group,37 in the TR+C0 group,and 40 in the TR+C1 *** function was assessed by using the Montreal Cognitive Assessment Scale(MoCA).Results The proportion of patients with cognitive impairment in the AC group at 24 weeks was higher than that at baseline(Palcohol consumption impairs cognitive function,as evidenced by a signifi

关键词： alcohol dependence cognitive function repetitive transcranial magnetic stimulation cognitive behavioral therapy

Effects of phosphodiesterase-4 inhibition on alcohol consumption and withdrawal anxiety in Fawn Hooded rats:Evidence for CREB phosphorylation in accumben nucleus core and central amygdala

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Effects of phosphodiesterase-4 inhibition on alcohol consump...