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Studies on Parkinson’s-Disease-Linked Genes, Brain Urea Levels and Histopathology in Rotenone Induced Parkinson’s Disease Rat Model

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World Journal of Neuroscience 2020年第4期10卷 216-234页

作者： Suchitra Kavuri Senthilkumar Sivanesan Mathew D. Howell Rajagopalan Vijayaraghavan Jayakumar Rajadas Department of Research and Development Saveetha Institute of Medical and Technical Sciences Chennai India Department of Biochemistry Alluri Sitarama Raju Academy of Medical Sciences Eluru India Biomedical Editor St. Petersburg FL USA Biomaterials and Advanced Drug Delivery Laboratory Stanford University School of Medicine Stanford CA USA Department of Bioengineering and Therapeutic Sciences School of Pharmacy and Medicine University of California San Francisco San Francisco CA USA

Parkinson’s disease (PD) is a debilitating neurological disorder that affects the aged population globally. This study aimed to explore how oral- and intraperitoneal-rotenone-induced PD alters brain urea levels, histopathology, and key Parkinsonism-related genes in the striatum. Hematoxylin and eosin staining was performed for histopathology assessment and real-time polymerase chain reaction was performed for gene expression. Rotenone 3 mg/kg body weight (Rot-3-ip) for 21 days and rotenone 50 mg/kg body weight (Rot-50-po) for 28 days significantly (p Snca, Becn1 and Prkaa1 gene expression in the striatum. Lewy bodies were visible in both Rot-3-ip and Rot-50-po rat brains. There were contrasting features in brain and liver histopathology between the oral and intraperitoneal rotenone treatment groups. However, there was no significant (p can have different impacts on the pathological sequence of events based on the molecular approach.

关键词： Parkinson’s Disease Rotenone Intraperitoneal and Oral Brain Urea al-pha-synuclein Beclin-1 AMP-Activated Protein Kinase Brain and Liver Pa-thology

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