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Inhibitory activities of extracts of Rumex dentatus, Commelina benghalensis, ajuga bracteosa, Ziziphus mauritiana as well as their compounds of gallic acid and emodin against dengue virus

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Asian Pacific Journal of Tropical Medicine 2018年第4期11卷 265-271页

作者： Riffat Batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow Department of Plant Sciences Faculty of Biological Sciences Quaid-i-Azam University Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore

Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue.

关键词： Dengue virus Rumex dentatus Commelina benghalensis ajuga bracteosa Ziziphus mauritiana Gallic acid

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A review of therapeutic potential of ajuga bracteosa:A critically endangered plant from Himalaya

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Journal of Coastal Life Medicine 2016年第11期4卷 918-924页

作者： Mubashir Hussain Yamin Bibi Naveed Iqbal Raja Muhammad Iqbal Sumaira Aslam Nida Tahir Muhammad Imran Anam Iftikhar Department of Botany PMAS Arid Agriculture UniversityRawalpindiPakistan Department of Fisheries and Aquaculture University of Veterinary and Animal SciencesLahorePakistan

Medicinal plants are the nature’s gift for the humanity to treat various ailments and to spend a prosperous healthy life.There are almost 300 species of ajuga.Among them,ajuga bracteosa Wall.ex Benth(A.bracteosa)is an important medicinal plant of Himalaya regions.Its medicinal potential is due to the presence of various pharmacologically active compounds such as neo-clerodane diterpenoids,flavonol glycosides,iridoid glycosides,ergosterol-5,8-endoperoxide and phytoecdysones.The aim of this review article was to gather information about A.bracteosa which is currently scattered in form of various publications.This review article tried to attract the attention from people for therapeutic potential of A.bracteosa.The present review comprises upto date information of botanical aspects,active ingredients,traditional uses,and pharmacological activities such as antitumor,antimicrobial,antimalarial,anti-inflammatory,cardiotonic activity,antiarthritic activity,antioxidant activity and in vitro production of secondary metabolites for pharmaceuticals.Due to remarkable medicinal potential and commercialization,this species is indexed into critically endangered category and it is facing extremely high risk of extinction.Conservation practices and management techniques should be carried out to protect this important species from extinction.Recent biotechnological approaches will be quite helpful for its conservation.

关键词： ajuga bracteosa Critically endangered Pharmacology Antitumor Himalaya

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