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Consecutive allergen challenges resulted in decreased bronchial responsiveness

Chinese Medical Journal 2002年第11期115卷 1727-1729,156页

作者：贺建新江载芳首都医科大学附属北京儿童医院呼吸科北京100045

OBJECTIVE: To investigate bronchial responsiveness to acetylcholine in allergic airway inflammation of SD rats. METHODS: SD rats were immunized and challenged by chicken ovalbumin (OVA). airway responsiveness, acetylcholine (Ach) provocation concentration needed to increase baseline airway resistance by 200% (PC(200)) were measured. RESULTS: The value of baseline airway resistance in asthma group was significantly higher than that in control group (2.282 +/- 0.128 vs 3.193 +/- 0.239; P

关键词： Acetylcholine airway resistance Allergens Animals Bronchi Bronchial Hyperreactivity Bronchoconstriction Lung Male Ovalbumin Rats Rats, Sprague-Dawley

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Improvement of pulmonary function by inhaled rosuvastatin involves reversed central CD73 downregulation in asthmatic rats

Improvement of pulmonary function by inhaled rosuvastatin in...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者： Hong Chen Ming Zeng Yun Lin 王继江 Department of Physiology and Pathophysiology Fudan University School of Basic Medical Sciences

Purpose: to test whether rosuvastatin is able to attenuate the downregulation of central CD73 and,subsequently, improve pulmonary function via attenuation of the increase of airway vagal ***: experimental rat model of allergic asthma was prepared using ovalbumin with or without simultaneous treatment with inhalation of rosuvastatin, and the effects of inhaled rosuvastatin were examined by plethysmographic measurement of pulmonary function, hematoxylin and eosin staining of the lungs, and molecular biological assay of the expression and activity of medullary ***: in ovalbumin-sensitized rats, the expression and activity of medullary CD73 were significantly decreased;ATP concentration in cerebral spinal fluid was significantly increased, and all of which were reversed in rats treated with inhaled *** rosuvastatin abolished the increase of airway resistance and decrease of dynamic compliance of the ***: in rat model of allergic asthma, inhaled rosuvastatin reverses the decreases in the expression and activity of brainstem CD73, and via which abolishes the increase of airway vagal activity and improves pulmonary function.

关键词： allergic asthma airway resistance vagus nerve ecto-5’-nucleotidase

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Orexin excites airway vagal preganglionic neurons in ventral medulla in rat

Orexin excites airway vagal preganglionic neurons in ventral...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：王继江陈咏华葛登云闫先侠郭玉红复旦大学上海医学院生理与病理生理系

airway functions are under the control of the vagus nerve which centrally originates from airway-related vagal preganglionic neurons(AVPNs)in the nucleus ambiguus(NA)and the dorsal motor nucleus of the vagus(DMV)in medulla *** AVPNs may be regulated by orexin,a peptide produced by hypothalamic neurons and proved to regulate multiple physiological functions including *** this study,we investigated 1)the expression of orexin receptors in the AVPNs which were retrogradely labeled by fluorescent injected into the trachea wall;2)the effect of orexin on the AVPNs in brainstem slices using patch-clamp techniques;3)the physiological effects of centrally administrated orexin in anesthetized *** found that the AVPNs in the NA were stained for orexin 1 receptors;bath application of orexin-A increased the excitability of AVPNs and enhanced the synaptic inputs of AVPNs,including glutamatergic,GABAergic and glycinergic transmissions;central administration of orexin-A into the cisterna magna of juvenile rats produced a significant increase in airway resistance(RL and Re)and a significant decrease in dynamic compliance(Cdyn).These results indicate that orexin regulates the activities of AVPNs and have a role in the control of airway functions.

关键词： orexin airway vagal preganglionic neuron orexin 1 receptor synaptic transmission airway resistance

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