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Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with aggressive periodontitis

Chinese Medical Journal 2015年第4期128卷 528-532页

作者： Dong Shi Yun-Yu Liu Wei Li Xin Zhang Xiao-Jun Sun Li Xu Li Zhang Zhi-Bin Chen Huan-Xin Meng Department of Periodontology Peking University School and Hospital of Stomatology Beijing 100081 China

Background：Increasing evidence supports an association between periodontitis and systemic *** is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic *** present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis （AgP） and to explore the relationship between leptin and systemic ***：Ninety patients with AgP visiting the Clinic of the Periodontology Department,Peking University School and Hospital of Stomatology between July 2001 and May 2006,and 44 healthy controls （staffand student volunteers in the same institute） were *** levels of leptin and inflammatory cytokines including interleukin （IL）-1β,I L-6,tumor necrosis factor-α （TNF-α） and C-reactive protein （CRP） were measured by enzyme-linked immunosorbent *** and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other ***：Plasma leptin level of AgP group was significantly higher than that of the control group （19.7-4.4 ng/ml vs.7.5 ± 1.3 ng/ml,P ＜ 0.01）.After controlling for age,gender,and body mass index,positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines （IL-1β,IL-6,TNF-α and CRP）,and the partial correlation coefficients ranged from 0.199 to 0.376 （P ＜ 0.05）.Log-transformed IL-1β and I L-6 levels entered the final regression model （standardized β were 0.422 and 0.461 respectively,P ＜ 0.01）.Conclusions：Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.

关键词： aggressive periodontitis Inflammation Mediators Leptin

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Identification of Dermal Crease Patterns as a Link between Genetics and periodontitis:Reliability and Credibility

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Journal of Forensic Science and Medicine 2024年第2期10卷 106-110页

作者： B.Bharghavi Patnaik Gautami S.Penmetsa Keerthi Vinnakota Alluri Venkata Ramaraju Rama Krishna Alla Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Prosthodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Dental Materials Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Introduction:The disruptions in the ectodermal layer during intrauterine growth in the process of the formation of epidermal ridges can be linked to the association between dermatoglyphics and abnormalities of the tooth and *** the genetic linkage of periodontal disease this study was hypothesized at observing the association of chronic periodontitis,aggressive periodontitis,and individuals with healthy periodontium as per the 1999 AAP classification of periodontitis with their fingerprint patterns and ridge *** and Methods:Patients belonging to an age cohort of 18-50 who visited the department of periodontics and implantology were included in the ***’periodontal status was determined and was enrolled in the study.A total of 114 subjects were compared,where 38 subjects belonged to the individual group of periodontal condition that are designated as Group A(healthy),Group B(chronic periodontitis),and Group C(aggressive periodontitis).A total of 1140 fingerprints were *** were analyzed and classified according to their patterns and also the ridges were ***:The comparison between three groups showed a statistically significant difference between increased percentage frequency of radial loops(28%)in chronic periodontitis and plain whorls(26.3%)in aggressive *** was a significant difference between ridge count among all the three groups,the highest being in healthy and the least between aggressive periodontal ***:Observations of the study show that there was a difference in fingerprint pattern between patients of all the three periodontal conditions indicating a link between epidermal ridges and condition of periodontium.

关键词： aggressive periodontitis chronic periodontitis dermatoglyphics genetics

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