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Application of dexmedetomidine in different doses in combined with propofol in the painless colonoscopy in the elder patients

引用

Journal of Hainan Medical University 2018年第2期24卷 71-74页

作者： Yan-Jun Li Jian-Xin Zhang Gastrointestinal Endoscope Room People’s Hospital of Qianxi CountyTanshanHebei064300China Department of Anesthesia Kailuan General HospitalTanshanHebei063000China

Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder ***: A total of 60 elder patients who were admitted in our hospital from November 2016 to October 2017 for selective painless fiber colonoscopy were included in the study and divided into the low dose group and high dose group according to Dex dose. The micro-infusion pump was used to inject Dex 10 min before examination. The load capacity in the low dose group was 0.25 μg/kg, while in the high dose group was 0.75 μg/kg. The pump injection was completed within 10 min, then a continuous pump injection was performed in a speed of 0.5 μg/kg/h until the check off. After the completion of Dex pumping, propofol (1-1.5 mg/kg) was slowly injected. MAP, HR, and SpO2 before medication (T0), 5 min after inserting the endoscope (T1), and the time after the examination being finished (T2) were recorded, respectively. The bioelectrical impedance technique was used to continuously monitor SV, CO, and SVR. The awakening time, propofol dose, and discharge time were ***: The comparison of MAP, HR, and SpO2 at T0 between the two groups was not statistically significant. MAP, HR, SV, CO, and SVR at T1 and T2 were significantly lower than those at T0, while the comparison of SpO2 was not significantly changed. MAP at T1 in the high dose group was significantly higher than that in the low dose group, while HR at T1 and T2 was significantly lower than that in the low dose group. SV, CO, and SVR at T1 and T2 in the high dose group was significantly higher than those in the low dose group. The awakening time in the high dose group was significantly shorter than that in the low dose group, and the propofol dose was significantly less than that in the low dose group, while the comparison of discharge time was not significantly different. Conclusions: Application of Dex in a high dose in the painless colonoscopy in t

关键词： Dex propofol agedness Fiber colonscope

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Efficacy of the apatinib and icotinib combination therapy in the treatment of icotinib-resistant advanced lung adenocarcinoma:A case study

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TMR Cancer 2021年第5期4卷 4-7页

作者： Ling-Juan Gao Oncology Department The 81st Group Army Hospital of PLAZhangjiakouChina

A patient with advanced lung adenocarcinoma who was unable to tolerate chemotherapy was controlled after combined treatment with *** case provides a basis for the treatment of this disease using this ***:The diagnosis of patients with lung adenocarcinoma stageⅣperiod,age,detection of EGFR mutations,line for treatment in September there progress,a large number of pleural effusions,the right lung neoplasm,cisplatin and interleukin-2 pleural perfusion chemotherapy,line *** of the EGFR gene exon 20 single did not identify a missense mutation(T790M not mutation).Patients with high collar,poor health,refused ***,we administered oral treatment of apatinib at 250 mg/***:Apatinib combined with EGFR-TKI targeted therapy is effective for lung ***,adverse reactions can be controlled.

关键词： Apatinib EGFR-TKI Lcotinib hydrochloride tablets agedness lung adenocarcinoma

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