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Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus

World Journal of Diabetes 2017年第5期8卷 187-201页

作者： Taras Vitak Borys Yurkiv Solomon Wasser Eviatar Nevo Natalia Sybirna Department of Evolutionary and Environmental Biology Faculty of Natural ScienceUniversity of Haifa Institute of Evolution and Department of Evolutionary and Environmental Biology Faculty of Natural ScienceUniversity of Haifa Institute of Evolution Faculty of Natural ScienceUniversity of Haifa Department of Biochemistry Faculty of BiologyIvan Franko National University of Lviv

Diabetes mellitus(DM) is the third most common noninfectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of microand macroangiopathies. Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells. As a result, the oxygen-transport function of red blood cells(RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected. Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels. Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin. Medicinal mushrooms play an important role among such new preparations. They are a source of a large number of high-and lowmolecular compounds with pronounced biological effects. Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms agaricus brasiliensis(A. brasiliensis) and Ganoderma lucidum(G. lucidum) on streptozotocin-induced DM in rats. Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers. Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabeticrats treated with A. brasiliensis a

关键词： Diabetes mellitus Streptozotocin agaricus brasiliensis Ganoderma lucidum Leukocytes Red blood cells

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