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Compounds from african medicinal plants with Activities Against Selected Parasitic Diseases:Schistosomiasis,Trypanosomiasis and Leishmaniasis

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Natural Products and Bioprospecting 2018年第3期8卷 151-169页

作者： Conrad V.Simoben Fidele Ntie-Kang Sergi H.Akone Wolfgang Sippl Institute of Pharmacy Martin-Luther University of Halle-WittenbergWolfgang-Langenbeck-Str.406120 Halle(Saale)Germany Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63Buea 00237Cameroon Institute of Pharmaceutical Biology and Biotechnology Heinrich-Heine-UniversityUniversitaetsstrasse1Geb.26.23Duesseldorf 40225Germany Department of Chemistry Faculty of ScienceUniversity of DoualaPO Box 24157Douala 00237Cameroon

Parasitic diseases continue to represent a threat on a global scale,particularly among the poorest countries in the world.This is particularly because of the absence of vaccines,and in some cases,resistance against available drugs,currently being used for their treatment.In this review emphasis is laid on natural products and scaffolds from african medicinal plants(AMPs)for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases.In the discussion,emphasis has been laid on alkaloids,terpenoids,quinones,flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma,Trypanosoma and Leishmania species.In each subparagraph,emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds.Suggestions for future drug development from african medicinal plants have also been provided.This review covering 167 references,including 82 compounds,provides information published within two decades(1997-2017).

关键词： african medicinal plants Leishmaniasis Natural products Parasitic diseases Schistosomiasis Trypanosomiasis

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Hypoglycemic Potential of african medicinal plants in Diabetic and Non-Diabetic Human Subjects: A Review

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Clinical Complementary Medicine and Pharmacology 2023年第2期3卷 39-49页

作者： Aminu Mohammed Department of Biochemistry Ahmadu Bello University81000 ZariaKaduna StateNigeria

Africa is blessed with several plants and marine organisms used to treat various diseases including diabetes.The folkloric use of some of these plants in treating diabetes has been documented in various databases and publi-cations,and validated using various diabetes models.However,most of the investigations on african medicinal plants as antidiabetic agents are not taken beyond proof-of-concept stage.Besides,limited number of clinical trials were conducted to validate the efficacy in humans and the few available clinical studies have not been critically reviewed.Therefore,this review is intended to document the antidiabetic potential of african medici-nal plants investigated in human subjects as well their safety implications.Relevant articles were harvested from the major scientific databases(Scopus,PubMed,and Google Scholar).According to the present search,eighteen(18)african medicinal plants and one herbal formulation were the only plants investigated for antidiabetic ac-tivity in humans.The plants showed no noticeable toxicity throughout the study period.Interestingly,all the 18 plant species were traditionally used to treat diabetes in various parts of Africa.Despite variations in the study period and dosages used,Laportea ovalifolia(Schumach.&Thonn.)Chew.(Urticaceae)and Momordica charantia L.(Cucurbitaceae)were the most effective as they reduced fasting blood glucose by>50%after 10 days and 4 weeks treatment periods,respectively.The available information revealed that african medicinal plants espe-cially L.ovalifolia and M.charantia should be subjected to phase III clinical trial,aimed at getting the natural product-based antidiabetic drugs from Africa.

关键词： african medicinal plants Diabetes Clinical trial Hyperglycemia Safety

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