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aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway

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Journal of Integrative Medicine 2021年第5期19卷 418-427页

作者： Tong Zhao Bing-jie Guo Chu-lan Xiao Jiao-jiao Chen Can Lü Fan-fu Fang Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Nanjing University of Chinese Medicine.Nanjing 210023 Jiangsu ProvinceChina

Objective: exercise, as a common non-drug intervention, is one of several lifestyle choices known to reduce the risk of cancer. Mitochondrial division has been reported to play a key role in the occurrence and transformation of hepatocellular carcinoma(HCC). This study investigated whether exercise could regulate the occurrence and development of HCC through ***: Bioinformatics technology was used to analyze the expression level of dynamin-related protein1(DRP1), a key protein of mitochondrial division. The effects of DRP1 and DRP1 inhibitor(mdivi-1) on the proliferation and migration of liver cancer cells BEL-7402 were observed using cell counting kit-8, plate colony formation, transwell cell migration, and scratch experiments. Enzyme-linked immunosorbent assay, Western blot and real-time polymerase chain reaction were used to detect the expression of DRP1 and its downstream phosphoinositide 3-kinase(PI3 K)/protein kinase B(AKT) pathway. A treadmill exercise intervention was tested in a nude mouse human liver cancer subcutaneous tumor model expressing different levels of DRP1. The size and weight of subcutaneous tumors in mice were detected before and after ***: The expression of DRP1 in liver cancer tissues was significantly upregulated compared with normal liver tissues(Paerobic exercise was able to inhibit the expression of DRP1 and decrease the size and weight of subcutaneous tumors. Moreover,the expression of phosphorylated PI3 K(p-PI3 K) and phosphorylated AKT(p-AKT) decreased in the exercise group. However, exercise could not change p-PI3 K and p-AKT levels after knocking down DRP1 or using mdivi-1 on subcutaneous ***: aerobic exercise can suppress the development of

关键词： aerobic exercise Hepatocellular carcinoma Dynamin-related protein PI3K/AKT pathway

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aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo:a pilot study in rats

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Asian Journal of Andrology 2023年第5期25卷 637-642页

作者： Yuan-Yuan Huang Dang-Wei Peng Qiu-Shi Liu Hui Jiang Xian-Sheng Zhang Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Urology Peking University First HospitalBeijing 100000China Andrology Center Peking University First HospitalBeijing 100000China Institute of Urology Peking UniversityBeijing 100000China

Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and *** aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors,as well as to make a preliminary assessment of aerobic exercise as a complementary strategy to dapoxetine treatment in rapid *** tests of rats and a treadmill training protocol were performed in this *** total,12 rapid ejaculators were selected on the basis of ejaculation distribution theory and randomly assigned to 4 groups:control(Ctrol)group,aerobic exercise(Ex)group,dapoxetine(Dapo)group,and Ex+Dapo *** evaluated the changes in ejaculatory parameters in the 4 *** in biological markers,including serum corticosterone,serotonin(5-HT),and brain-derived neurotrophic factor(BDNF)of the raphe nucleus,were determined by enzyme-linked immunosorbent assay(ELISA).The primary finding of our study was that both aerobic exercise and acute dapoxetine could enhance ejaculation control and prolong ejaculation latency in rapid ejaculator *** ejaculation delay effect of aerobic exercise was nearly equivalent to that of acute *** addition,both aerobic exercise and dapoxetine treatment could lead to increased expression of BDNF and 5-HT in the raphe nucleus of rapid ***,the two interventions,when applied together,may further upregulate the expression of BDNF-5-HT duo in a complementary *** study highlights the positive effects of aerobic exercise on ejaculation *** aerobic exercise might be a promising complementary treatment to dapoxetine in rats.

关键词： aerobic exercise animal model brain-derived neurotrophic factor premature ejaculation raphe nucleus serotonin

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aerobic exercise combined with huwentoxin-I mitigates chronic cerebral ischemia injury

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Neural Regeneration Research 2017年第4期12卷 596-602页

作者： Hai-feng Mao Jun Xie Jia-qin Chen Chang-fa Tang Wei Chen Bo-cun Zhou Rui Chen Hong-lin Qu Chu-zu Wu Key Laboratory of Physical Fitness and exercise Rehabilitation of Hunan Province Hunan Normal University College of Physical Education Yichun University

Ca2＋ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I （HWTX-I）, a spider peptide toxin that blocks Ca2＋ channels, into the caudal vein of a chronic cerebral ischemia mouse model, once every 2 days, for a total of 15 injections. During this time, a subgroup of mice was subjected to treadmill exercise for 5 weeks. Results showed amelioration of cortical injury and improved neurological function in mice with chronic cerebral ischemia in the HWTX-I ＋ aerobic exercise group. The combined effects of HWTX I and exercise were superior to HWTX-I or aerobic exercise alone. HWTX-I effectively activated the Notch signal transduction pathway in brain tissue. aerobic exercise up-regulated synaptophysin mRNA expression. These results demonstrated that aerobic exercise, in combination with HWTX-I, effectively relieved neuronal injury induced by chronic cerebral ischemia via the Notch signaling pathway and promoting synaptic regeneration.

关键词： nerve regeneration chronic cerebral ischemia aerobic exercise huwentoxin-I Notch signaling pathway calcium overload neuralregeneration

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aerobic exercise improves gastrointestinal motility in psychiatric inpatients

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World Journal of Gastroenterology 2014年第30期20卷 10577-10584页

作者： Yeon Soo Kim Bong Kil Song Ji Sun Oh Seung Seok Woo Health and exercise Science Laboratory Institute of Sports ScienceSeoul National UniversitySeoul 151-742South Korea

AIM: To evaluate the benefit of aerobic exercise on colonic transit time (CTT) for psychiatric inpatients in a closed ward.

关键词： Intestinal motility Colonic transit time aerobic exercise Radio-opaque marker Psychiatry unit Inpatient

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Effects of aerobic exercise on Atherosclerotic Risk in Postmenopausal Women

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Journal of Science in Sport and exercise 2019年第2期1卷 132-141页

作者： Mengting Luo Peizhen Zhang Xinglong Zhou Xin Zhang Wei Zhao Yuming Bai School of Sport Medicine and Rehabilitation Beijing Sport UniversityNo.48 Xinxi RoadHaidian districtBeijing 100084People’s Republic of China College of exercise Medicine Chongqing Medical UniversityChongqingPeople’s Republic of China Sport Science College Beijing Sport UniversityBeijingPeople’s Republic of China

Introduction To study the effects of aerobic exercise on lipid metabolism,endothelial function,and oxidative stress reaction in postmenopausal women,in order to prevent and control *** Thirty-two women with natural menopause were randomly divided into an exercise group and a control *** in the exercise group(n=16)took part in a 3-month aerobic training program according to their exercise pre-scription,while participants in the control group(n=16)maintained their usual ***,endothelial function,and oxidative stress-related indicators were measured before and after the *** After 3 months of aerobic training at an intensity of 50-60%of cardiorespiratory fitness,serum total cholesterol and low-density lipoprotein cholesterol decreased significantly(Paerobic exercise had a positive effect on blood lipids,endothelial function,and oxidative stress of postmeno-pausal women,and these changes may mitigate the risk of atherosclerosis *** exercise programs could be used as a primary atherosclerosis prevention strategy for postmenopausal women.

关键词： aerobic exercise Postmenopausal women Atherosclerosis Endothelial function Oxidative stress

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Psychophysiological effects of rhythmic music combined with aerobic exercise in college students with minimal depressive symptoms

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Sports Medicine and Health Science 2022年第4期4卷 267-274页

作者： Ping Yang Hui Yang Yang Cao Xin Yang Benxiang He Postdoctoral Research Mobile Station of Sports Science Chengdu Sport UniversityNo.2Tiyuan RoadChengduSichuan610041China Department of Physical Education Shangrao Normal UniversityNo.401Zhimin RoadShangraoJiangxi334001China Department of Physical Education Jiangxi Science and Technology Normal UniversityNo.589Xuefu AvenueHongjiaozhou CampusNanchangJiangxi330036China

Mental health problems are common during the transition from adolescence to young *** studies reported that rhythmic music plus aerobic exercise can have a beneficial effect on emotional *** examined whether the beneficial effect differed between aerobic exercise interventions with or without rhythmic music.A sample of 94 college students who either had no depressive symptoms(n=47)or minimal depressive symptoms(n=47)underwent 30-min interventions in a randomized and counterbalanced order:rest,rhythmic music,aerobic exercise and aerobic exercise plus rhythmic *** time and accuracy of selective attention to positive and negative images were recorded using the spatial cueing ***’heart rate during all conditions and perceived exertion after each condition were measured to clarify physiological and perceptual responses,*** results revealed that a multimodal intervention combining aerobic exercise and rhythmic music had a significant facilitatory effect on attentional bias to positive emotional cues in minimal depressive participants(t=-2.336,p=0.024),including less perceived exertion and higher heart rate after/during the intervention *** single-modality intervention of aerobic exercise had significant positive effects for individuals with no depressive symptoms(t=2.510,p=0.016).The multimodal intervention was more effective than the single-modality intervention for individuals with minimal depressive symptoms,but the single-modality aerobic exercise intervention was more effective for individuals with no depressive symptoms,providing new evidence for the specificity of the intervention effect for people with different degrees of depressive symptoms.

关键词： Multimodal intervention Depression aerobic exercise Rhythmic music Attentional bias

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Effect of aerobic exercise on the contractile function of gastrocnemius myosin heavy chain

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Journal of Pharmaceutical Analysis 2009年第2期21卷 78-85页

作者： Wen-jun Ren The Key Laboratory of Biomedical Information Engineering of Education Ministry,School of Life Science and Technology,Department of Physical Education,Xi’an Jiaotong University,Xi’an 710061,China. School of Life Science and Technology Department of Physical Education Xi'an Jiaotong University Xi'an 710061 China

Objective To study the effect of 4-6 weeks’ treadmill training of male SD rats on the contractile function of their gastrocnemius myosin heavy chain (MHC). Methods Forty male SD rats were randomly divided into control group and training group. The treadmill training of the training group rats was incessantly performed for 4-6 weeks at an intensity of about 75% VO2max (18.5-24 m/min,gradient of 0°,each training session lasting 50 minutes,twice a day). The content of gastrocnemius MHC mRNA was tested by reverse transcription polymerase chain reaction (RT-PCR),and the changes of muscle fibre and its cross-section area (CSA) were measured using immunohistochemistry. Electric stimulation tests were used to determine the maximal tension of isometric contraction of the post-training gastrocnemius. Results ① After continuous treadmill training for 4-6 weeks,we found that the content of the total MHC,MHC Ⅰ,MHC Ⅱx,MHC Ⅱa mRNAs was 105%,105%,109% and 108% of that in the resting control group,respectively,and the MHC Ⅱb mRNA content did not change significantly. The percentage of MHC Ⅰ mRNA in the total MHC mRNA increased while that of MHC Ⅱ mRNA decreased after aerobic training. ② The slow type of fibre type Ⅰ was the main part of the MHC after training and the CSA of the muscle fibres increased simultaneously. ③ The maximal tension of isometric contraction by pulse stimulation of square wave in the training group increased significantly compared with that in the control group (Paerobic exercise may promote an increase in the contractile function of MHC.

关键词： aerobic exercise myosin heavy chain mRNA cross-section area

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Low-intensity aerobic exercise training attenuates airway inflammation and remodeling in a rat model of steroid-resistant asthma

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Chinese Medical Journal 2014年第17期127卷 3058-3064页

作者： Qin Qingwu Chen Xi Feng Juntao Qin Ling Hu Chengping Department of Respiratory Medicine Xiangya Hospital Central South University National Clincial Research Center for Respirator3[ Disease Changsha Hunan 410008 China Bronchial Asthma Research Center of Hunan Province Changsha Hunan 410008 China

Background aerobic exercise can improve symptoms,reduce airway inflammation,and even ameliorate airway remodeling in asthmatic animals and ***,previous studies have focused mainly on the effect of aerobic exercise on steroid-sensitive asthma （SSA）.The goals of this study were to determine the effect of low-intensity aerobic exercise training on airway hyperresponsiveness,inflammation,and remodeling in a rat model of steroid-resistant asthma （SRA） and to identify the potential mechanisms underlying these *** Endotoxin-free ovalbumin with or without lipopolysaccharide were applied to establish rat models of SRA and SSA,*** hyperresponsiveness,inflammation,remodeling,expression of interleukin （IL）-25,IL-33,thymic stromal lymphopoietin （TSLP）,high mobility group box-1 （HMGB1）,and IL-17 in bronchoalveolar lavage fluid （BALF）,and the role of dexamethasone （DXM） were compared between these two asthmatic rat *** effect of low-intensity aerobic exercise training and anti-HMGB1 treatment on airway hyperresponsiveness,inflammation,and remodeling in SRA rats also was *** SRA rats developed neutrophil-dominated airway inflammation （（29.5±4.1）％ of the total cell numbers in BALF）,whereas SSA rats developed eosinophil-dominated airway inflammation （（24.0±6.1）％ of the total cell numbers in BALF）.Compared with SSA rats,SRA rats had more severe airway hyperresponsiveness,lower levels of IL-25 （（33.6±10.3） vs.（104.8±24.9） pg/ml）,IL-33 （（87.5±25.0） vs.（226.6±40.7） pg/ml）,and TSLP （（1 933.2±899.5） vs.（7 224.0±992.1） pg/ml）,and higher levels of HMGB1 （（21.2±4.5） vs.（5.4±1.6） ng/ml） and IL-17 （（780.5±261.7） vs.（291.4±76.4） pg/ml） in BALF （all P ＜0.05）.However,there was no significant difference in goblet cell hyperplasia,subepithelial collagen thickness,and airway smooth muscle remodeling between the two *** with control SSA rats,airway hyperresponsiveness,inflammation,and remodeling in SRA rats were less sensitive t

关键词： aerobic exercise inflammation airway remodeling steroid-resistant asthma high mobility group box-1

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aerobic exercise regulates the expression of NADPH oxidase in PVN of spontaneously hypertensive rats

Aerobic exercise regulates the expression of NADPH oxidase i...

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中国神经科学学会第十届全国学术会议

作者： Yan LI Li ZHAO Bo-Ya GU College of exercise Science Beijing Sport University

Objective Excessive sympathetic activity contributes to the initiation and progression of *** oxygen species（ROS） in the paraventricular nucleus（PVN） is involved in sympathetic overdrive and *** oxidase is one of the major sources of ROS in *** research suggest that NADPH oxidase expression and activity has been increased in PVN of hypertensive animal models,and blood pressure（BP）,is reversed by treatment with nonspecific NADPH oxidase *** exercise has been shown beneficial effects on the cardiovascular parameters in hypertensive patients and animal *** whether NADPH oxidase in PVN involved in the exercise induced BP decrease in SHR is largely *** study is to investigate the effects of exercise on the expression of NADPH oxidase in PVN of *** 13 months SHR were randomly divided into sedentary（SSED） and exercise（SEX,20m/min,60min/d,5d/w,Sweeks） *** control groups included Sprague-Dawley（SD） rats and Wistar-Kyoto（WKY） *** rate（HR） and BP were measured and analysed using a noninvasive tail-cuff *** norepinephrine（NE） level was quantified using the rat NE ELISA *** expressions of PVN NADPH oxidase subunits,including gp91-phox,p22-phox,p47-phox,p40-phox,p67-phox and Racl,were detected using western *** were analyzed using one-way analysis of variance（ANOVA）.The level of statistical significance was set at P＜*** HR,BP,plasma NE level,PVN NADPH oxidase subunits,including p91-phox,p22-phox,p47-phox,p40-phox,p67-phox,but not Racl,was increased in SSED compared to those in SD and *** these parameters were decreased induced by exercise *** The data suggests that the NADPH oxidase expression in PVN of SHR can be regulated by aerobic exercise,which may be one of the neural molecular mechanisms of exercise induced cardiovascular adaptions in SHR.

关键词： aerobic exercise SHR PVN NADPH oxidase

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aerobic exercise Modulates Mitochondrial Permeability Transition Pore in APP/PS1 Transgenic Mice

Aerobic Exercise Modulates Mitochondrial Permeability Transi...

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中国神经科学学会第十二届全国学术会议

作者： Lianwei Mu Boya Gu Li Zhao Department of exercise Physiology Beijing Sport University Key Laboratory of Physical Fitness and exercise Ministry of Education Beijing Sport University

Objective: Mitochondrial permeability transition pore（MPTP） has a key role in mitochondrial function of oxidative phosphorylation by maintaining membrane potential. Amyloid-β（Aβ） interacting with cyclophilin D（Cy P-D）, the component of MPTP, induce excessive opening of MPTP resulted in disrupting mitochondrial membrane potential. As widely accepted physical activity is the effective measure of health promotion and mitochondrial function is important for metabolism during exercise, but the mechanisms underlying are still not well understood. This study observed the effects of 12 weeks aerobic exercise on MPTP function in 9-month-old APP/PS1 transgenic mice. Methods: 1) APP/PS1 transgenic mice（6-month-old） and C57 BL/6 J mice（6-month-old） were randomly divided into 12 weeks exercise（CE, AE） and sedentary（AS, CS） respectively. 2) The brains were subjected to immunofluorescence and immunohistochemistry and Dot blot to analyze the level of Aβ and soluble amyloid-β peptide oligomers（o Aβ）. 3) MPTP open was detected by immunofluorescence. 4) ELISA was used to detect the activity of cytochrome c oxidase（COXIV）, alcohol dehydrogenase（ABAD） in the cortex and hippocampus. 5) The protein levels of COXIV, ABAD, Cyp-D, adenine nucleotide translocase（ANT） 1, ANT2 and voltage dependent anion channel-1（VDAC-1） were measured using Western Blotting. Results: 1) CE animals showed decreaed o Aβ levels compared with CS mice. Aβ was aggregated at cortex and hippocampus in 9-month-old APP/PS1 transgenic mice（AS） and accompanied with a markedly increase of o Aβ. There was a decline detected in Aβ plaque burden and o Aβ content in AE than those of AS. 2) There was a significant increase in 9-month-old AS compared with the control cohorts（CS） in the mitochondrial permeability transition pore opening, and which was significantly decreased after aerobic exercise training. 3) 9 month-old APP/PS1 mice displayed a prominent increase in Cyp-D, ANT1 and VDAC-1 protein levels of the cortex and hippoc

关键词： aerobic exercise APP/PS1 transgenic mouse Aβ mitochondrial permeability transition pore

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