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Meta-analysis of single strain probiotics for the eradication of Helicobacter pylori and prevention of adverse events

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World Journal of Meta-Analysis 2015年第2期3卷 97-117页

作者： Lynne V McFarland Peter Malfertheiner Ying Huang Lin Wang Department of Medicinal Chemistry University of WashingtonSeattleWA 98195United States Health Services Research and Development VA Puget Sound Health Care SystemDepartment of Veterans AffairsSeattleWA 98101United States Universitatsklinikum Magdeburg AOR 39120 MagdeburgGermany Children’s Hospital of Fudan University

AIM:To assess the efficacy and safety of single strain probiotics for the:(1) eradication of Helicobacter pylori(***);(2) prevention of adverse events;and(3) prevention of antibiotic-associated diarrhea associated with eradication ***:We searched Pub Med(1960-2014),EMBASE(1974-2014),Cochrane Database of Systematic Reviews(1990-2014),and ISI Web of Science(2000-2014).Additionally,we conducted a grey literature search including contact with National Institutes of Health Clinical Trials Registry,abstracts from annual infectious disease and gastroenterology meetings,experts in the field and correspondence with *** controlled trials of *** positive adults or children treated with eradication therapy and assessing the adjunctive therapy with a single strain of probiotics were *** primary outcomes were the rates of eradication of *** and frequency of patients with adverse events or antibiotic-associated *** were pooled using fixed or random-effects models to calculate the relative risk and corresponding 95%CI and weighted on study *** explore possible explanations for heterogeneity,a priori subgroup analyses were conducted on daily probiotic dose,study population,and quality of the *** overall quality of the evidence for each probiotic strain was assessed using the GRADE ***:A total of 25 randomized controlled trials(28 treatment arms,with a total of 3769 participants) assessed one of six single probiotic strains as adjunctive treatments to standard eradication *** one probiotic strain significantly improved *** eradication rates:Saccharomyces boulardii(***) CNCM I-745 [pooled relative risks(p RR) = 1.11,95%CI:1.07-1.16].Only one probiotic strain(*** CNCM I-745) significantly prevented any adverse events(p RR = 0.42,95%CI:0.28-0.62).Both *** CNCM I-745 and Lactobacillus rhamnosus GG significantlyreduced antibiotic-associated diarrhea(p RR = 0.47,95%

关键词： Probiotics Safety Saccharomyces boulardii Helicobacter pylori Meta-analysis adverse reactions Diarrhea Lactobacillus rhamnosus Randomized clinical trials

Pharmacological and clinical evaluation of a new anti-flu drug, baloxavir marboxil

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Journal of Chinese Pharmaceutical Sciences 2020年第10期29卷 729-733页

作者： Jingjing Cao Jun Sun Shujuan Zhao Peizhi Ma Department of Pharmacy Henan Provincial People’s HospitalPeople's Hospital of Zhengzhou UniversitySchool of Clinical MedicineHenan UniversityZhengzhou 450003China

Baloxavir marboxil is a polymerase acidic(PA)endonuclease inhibitor,which is approved by the U.S Food and Drug Administration(FDA)on October 25,2018,for the treatment of uncomplicated influenza patients aged 12 years and *** the present work,we reviewed the pharmacodynamics,pharmacokinetics,drug interactions,clinical trials and adverse reactions of baloxavir marboxil.

关键词： Baloxavir marboxil Pharmacodynamics Pharmacokinetics adverse reactions

Clinical Effect of Photodynamic Therapy Combined Cryotherapy on Nonmelanoma Skin Cancer

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Advances in Modern Oncology Research 2019年第5期5卷 9-12页

作者： Stephen A.Cannistra Naveed Saleh Department of Transfusion Medicine National Institutes of HealthBethesdaMD 20892USA Department of Business Analytics Tunis Business SchoolEl MouroujTunisia

The purpose of this study was to investigate the clinical efficacy of photodynamic combined freezing in patients with non-melanoma skin cancer(NMSC).First,according to the treatment regimen,96 patients with NMSC were divided into study group(n=50)and control group(n=46).The control group was treated with 5-amino-ketovalic acid photodynamic therapy(ALAPDT),while the study group was treated with ala-PDT combined with *** analogue scale(VAS)scores,visual satisfaction,clinical efficacy,adverse reactions,and progression-free survival were compared between the two *** results showed that VAS score in the study group was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).The appearance satisfaction and total effective rate of patients in the study group were higher than those in the control group,and the difference was statistically significant(Padverse reactions in the study group was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).3 years progressionfree survival time and 3 years progression-free survival rate were compared between the two groups,and the difference was not statistically significant(P>0.05).Therefore,the combination of PDT and cryotherapy for non-melanoma skin cancer has a good clinical effect,which is conducive to the recovery of skin lesions,high patient satisfaction,fewer adverse reactions,and longer progression-free *** addition,the combined therapy can provide a new treatment idea for non-melanoma skin cancer patients who are not suitable for surgical treatment.

关键词： Photodynamic therapy 5-amino-ketovalic acid Recovery Non-melanoma skin cancer Clinical efficacy adverse reactions

Garlic:Medicinal Plant and Natural Aromatic Condiment

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Journal of Pharmacy and Pharmacology 2021年第12期9卷 414-419页

作者： Alexis Ruiz León Regina de Caridad Rodríguez Muñoz Ana Elena Rodríguez Cadalso Luis Pablo Ibáñez Silva Eduardo RafaelÁguila Turiño Lesvia Leonides Rodríguez Galdó Úrsula Cristina Pomares Ortega General Hospital Tomás Carreras Galeano Unit Trinidad 62600Sanctis SpíritusCuba Municipal University Center“Julio Antonio Mella”and Filial of Medical Sciences“Elena Fernández de Castro”Units Sanctis SpíritusCuba

Objective:To relate the presence of active metabolites with therapeutic effects of the Allium sativum L whose common name is Garlic,as well as its contraindications and adverse reactions and its use as ***:Searching about the topic in the last 5 years and present a general view of the Allium sativum L whose common name is ***:Technological prevision was based on the search of articles in the Virtual Library in Health(BVS)and using the key words“medicinal plants”/“spice”/Allium sativum L/garlic/adverse reactions and contraindications,and the association among them.

关键词： Medicinal plant Allium sativum L Garlic spice adverse reactions contraindications

Clinical Study on TACE Combined with Elemene Injection and Cinobufagin Injection Respectively for Middle and Advanced Primary Hepatic Carcinoma

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Advances in Modern Oncology Research 2020年第3期6卷 1-5页

作者： Xinyue Cui Zhizhong Ma Liaoning University of Traditional Chinese Medicine ShenyangChina Fleming Research Center of Life Sciences Singapore

Objective: To observe and compare the differences in the clinical effect and the incidences of adverse reactions oftranscatheter arterial chemoembolization(TACE) combined with elemene injection and cinobufagin injection respectively for middleand advanced primary hepatic carcinoma. Methods: A total of 104 cases of patients with middle and advanced primary hepaticcarcinoma who were treated in the oncology department from August 2018 to January 2020 were included as the study objects, andwere randomly divided into two groups according to different treatment regimens, 52 cases in each group. Both groups were treatedwith TACE once;the cinobufagin injection group was given intravenous infusion with 500 mL of 5% glucose injection and 10 mLof cinobufagin injection once a day. The elemene injection group was given intravenous infusion with elemene injection of 0.4 geach time and once a day. Both groups were treated for two courses, 15 days of continuous treatment with a rest of 15 days beingone course. The clinical effect, the changes in the indexes of liver function including alanine amino transferase(ALT), aspartatetransaminase(AST) and total bilirubin(TBil), the scores of alpha-fetoprotein(AFP) and Karnofsky (KPS) and tumor volumes aswell as the difference in the incidences of adverse reactions between the two groups were observed and compared. Results: Thetotal clinical effective rate was 88.46% in the elemene injection group and 71.15% in the cinobufagin injection group, and thedifference was significant(P0.05). After treatment, thedecrease of AFP, tumor volume and the increase of KPS scores in the elemene injection group were significantly more

关键词： Middle and advanced primary hepatic carcinoma Elemene injection Cinobufagin injection Transcatheter arterial chemoembolization Liver function Alpha-fetoprotein Tumor volume adverse reactions

"Endogenous wind " Theory theory in the prevention and treatment of anti-tumor treatment-related adverse reaction related research progress

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Cancer Advances 2021年第6期4卷 14-18页

作者： Huan-Huan Wen Hui-Yuan Wu Yan-Fei Yi Lu Xiao Zi-Yang Li Xi-Ya Yuan Yang Liu Zi-Yan Huang Ganzhou Tumor Hospital GanzhouChina The Affiliated Hospital of Jiangxi University of Chinese Medicine Nanchang 330006China Jiangxi University of Chinese Medicine Nanchang 330006China

The treatment of malignant tumor is mainly based on modern medical treatment,after treatment,there are many adverse reactions,such as dizziness,headache,fever,numbness of limbs,pruritus,rash,spasm,phalacrosis,elevated blood pressure,anemia,myelosuppression,impaired functions of liver and kidney."Endogenous wind"is a part of Traditional Chinese medicine,and the researches are mainly focused on tumor metastasis and *** researches on the adverse reactions associated with the treatment of malignant tumors are *** paper is built on the theory of"endogenous wind"of Chinese medicine,and initially analyzes the progress of the research on adverse reactions of malignant tumors after treatment by modern medical means.

关键词： “Endogenous wind”theory malignant tumor adverse reactions research progress

Analysis of the Efficacy of Triamcinolone Acetonide Combined with Ranibizumab in the Treatment of Fundus Diseases

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Journal of Clinical and Nursing Research 2023年第6期7卷 30-35页

作者： Wanqiu Jiao Jingwei Zhang Ning Ma Zhigang Ma Harbin Eye Hospital Harbin 150010Heilongjiang ProvinceChina

Objective:To analyze the effect of triamcinolone acetonide combined with ranibizumab in patients with fundus ***:100 patients with fundus diseases admitted from January 2018 to January 2023 were *** patients were separated into two groups according to the random number table method,with 50 cases in the control group(treated with ranibizumab),and 50 cases in the observation group(treated with triamcinolone acetonide combined with ranibizumab).The clinical effects of both treatment regimens were ***:The time taken for symptom disappearance of the observation group was shorter than that of the control group(Padverse reaction rate and a higher quality of life(Padverse reaction rate and better prognosis and quality of life.

关键词： Intravitreal injection of ranibizumab Monoclonal antibody treatment Fundus diseases adverse reactions Quality of life

Observation on the Clinical Effect of Stereotactic Body Radiotherapy in Patients with Oligometastatic Tumors

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Journal of Clinical and Nursing Research 2022年第6期6卷 12-25页

作者： Jiao Yu Gaofei Zhang Long Jin Xin Chen Hui Gao Shaojun Ma Zhuo Wu Department of Radiation Oncology Shaanxi Provincial People’s HospitalXi’an 710068China Department of Radiology Shaanxi Provincial People’s HospitalXi’an 710068China Department of Medical Equipment Shaanxi Provincial People’s HospitalXi’an 710068China

Objective:To observe the efficacy and safety of stereotactic body radiotherapy(SBRT)in the treatment of extracranial ***:A retrospective analysis of 70 patients with extracranial oligometastasis of malignant tumors who underwent SBRT in our hospital(Shaanxi Provincial People’s Hospital)from January 2019 to December 2021 with≤5 metastases,≤3 metastatic organs,and metastases with diameters of≤5 *** to the clinical data of patients,the dose-fractionation mode of SBRT is mainly determined according to the pathology of the primary tumor,the location of the metastatic tumor,and the important structures around the *** local control,survival and adverse reactions were ***:A total of 219 oligometastatic lesions in 70 patients were treated with *** median follow-up time was 24 months(12-40 months).The local control rate(LCR)of all target lesions assessed 3 months after radiotherapy was 94.1%;the 1-,2-,and 3-year LCRs were 88.6%,74.6%,and 64.9%,*** median progression-free survival(PFS)was 11.8 months(95%CI,8.9-14.7 months),and the 1-and 2-year PFS rates were 48.6%and 32.6%,respectively;the median overall survival(OS)was 31.9 month(95%CI 26.0-37.8 months),the 1-year OS rate was 84.3%.The local control time,PFS,and OS of patients with metastases≤3 cm were significantly better than those with metastases>3 cm,and the differences were statistically significant(Padverse reactions after SBRT treatment in oligometastatic patients were mainly bone marrow suppression and gastrointestinal reactions,with incidence rates of 48.98%and 30.61%,respectively;chronic adverse reactions were mainly pain(bone,muscle),radiation enteritis,and radiation pneumonitis,with incidence rates of 38.57%,30.00%,and 24.29%,*** treatment-related adverse reactions were mainly grade 1,which were all improved after symptomatic treatment,except for one patient with bone metastases from lung cancer who had grade 4 myelosuppress

关键词： Stereotactic body radiotherapy Extracranial oligometastases Efficacy adverse reactions

Application Value of High-Quality Nursing Intervention in Patients with Cirrhotic Ascites

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Journal of Clinical and Nursing Research 2022年第2期6卷 158-162页

作者： Yinhong Le Rongzhu Xu Yuan Chen Jianying Huang Yancheng No.1 People’s Hospital Yancheng 224000Jiangsu ProvinceChina

Objective:To study the application value of high-quality nursing intervention in patients with cirrhotic ***:From February 2018 to February 2020,80 patients with cirrhotic ascites,treated in Yancheng No.1 People’s Hospital,were selected as the subjects for this *** patients were divided into two groups based on the type of nursing intervention:a routine group and an observation group,with 40 cases in each *** routine group received routine nursing,and the observation group received high-quality nursing intervention on the basis of routine *** nursing effects and adverse reactions of the two groups were observed and ***:The total effective cases in the observation group were 39 cases,with a total effective rate of 97.5%;the total effective cases in the routine group were 33 cases,with a total effective rate of 82.5%.The total effective rate of the observation group was significantly higher than that of the routine group(Padverse reactions,in which the incidence of adverse reactions was 20.0%,whereas there were only two cases of adverse reactions in the observation group,in which the incidence of adverse reactions was 5.0%.The incidence of adverse reactions in the observation group was significantly lower than that in the routine group(Padverse reactions;thus,it should be popularized in clinical settings.

关键词： High-quality nursing intervention Cirrhotic ascites adverse reactions Nursing effect