检索结果-南通市图书馆

Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis:A case report

World Journal of Clinical Cases 2023年第34期11卷 8170-8175页

作者： Miju Bae Up Huh Chung Won Lee Jong Won Kim Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Venous adventitial cystic disease(VACD)is a rare disease characterized by cysts,filled with a gelatinous mucous substance similar to joint fluid,in the adventitia of blood vessels adjacent to the *** is often misdiagnosed as deep vein thrombosis(DVT),femoral varices,venous tumors,or *** SUMMARY A 69-year-old woman visited our hospital with a complaint of swelling in the right lower *** patient was diagnosed with DVT and prescribed apixaban at an outpatient *** 3 wk,the patient was hospitalized again because of sudden swelling in the right lower *** diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral *** patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year *** Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence.

关键词： adventitia Cysts Edema Joints Venous thrombosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis

引用

Nano Research 2023年第4期16卷 5311-5321页

作者： Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li Yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han College of Life Science Beijing University of Chinese MedicineBeijing 100029China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Pharmacy Baotou Medical CollegeBaotou 10040China Hebei Key Laboratory of Nanobiotechnology Yanshan UniversityQinhuangdao 066004China University of Chinese Academy of Sciences Beijing 100049China

Intervaginal space injection(ISI)is a novel mode of administration investigated over the last *** injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial *** transport has a certain delivery direction,and site-specific injection can work on specific organs or *** this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was *** prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to *** 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous ***,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the ***,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic *** proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly *** vascular elastic fibers at the plaque site were thickened,and fractures were *** was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques.

关键词： thoracic intervaginal space injection(tISI) gold nanoparticle(AuNP) tanshinone IIa sodium sulfonate liposome atherosclerosis adventitia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diet-induced hyperhomocysteinemia exacerbates vascular reverse remodeling of balloon-injured arteries in rat

引用

Chinese Medical Journal 2008年第22期121卷 2265-2271页

作者： GUO Yan-hong CHEN Feng-ying WANG Gui-song CHEN Li GAO Wei Department of Cardiology Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing 100191 China

Background While hyperhomocysteinemia is associated with an increased risk of cardiovascular diseases, the effect of hyperhomocysteinemia on the vascular adventitia and vessel remodeling has not been clearly demonstrated. We investigated the effect of the hyperhomocysteinemia on adventitial hyperplasia and vascular remodeling following balloon injury in rats and the underlying mechanisms. Methods Rats were fed with diet containing methionine for 4 weeks to increase plasma homocysteine before balloon injury. Vascular geometrical changes were assessed at different time points following balloon injury. The collagen deposition was determined by picrosirius red staining and immunohistochemical staining. Results When compared with normal diet group, moderate hyperhomocysteinemia in methionine diet group significantly exacerbated adventitial hyperplasia at day 7 and collagen deposition mainly in the adventitia at day 28 following balloon injury. The increased plasma homocysteine level significantly increased collagen deposition in the adventitia. There was a negative correlation （r=-0.698; P〈0.01） between the luminal area and the collagen content in the adventitia on day 28 following balloon injury. In cultured adventitial fibroblasts isolated from rat aorta, 100 pmol/L L-homocysteine （L-Hcy） significantly down-regulated matrix metalloproteinase-2 activity by 43% as determined by in vitro gelatin zymography （P 〈0.05） and up-regulated the expression of collagen type I by 187% （P 〈0.05） assessed by Western blotting. Conclusions Hyperhomocysteinemia exacerbated vascular constrictive remodeling by accelerated neointima formation and collagen accumulation in the adventitia. Increased collagen deposition may be the underlying mechanism.

关键词： homocysteine arteries adventitia collagen matrix metalloproteinase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：