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THE SIGNIFICANCE OF adrenoceptors IN THE ANTI-SHOCK EFFECTS OF TRH：PART Ⅱ．STUDIES ON THE ROLE OF TRH-SENSI-TIZATION OF ADRENOC

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中华创伤杂志 1995年第5期 80-84页

作者：刘良明陈惠孙胡德耀卢儒权

ＴｈｅＴＲＨｅｆｅｃｔｓｏｎｔｈｅｒｅｓｐｏｎｓｉｖｅｎｅｓｏｆａｎｉｓｏ┐ｌａｔｅｄｌｅｆｔａｔｒｉｕｍｔｒｅａｔｅｄｗｉｔｈ３ａｄｒｅｎｅｒｇｉｃａｇｏｎｉｓｔｓｗｅｒｅｏｂｓｅｒｖｅｄｉｎｒａｔｓｗｉｔｈｈｅｍ... 详细信息

ＴｈｅＴＲＨｅｆｅｃｔｓｏｎｔｈｅｒｅｓｐｏｎｓｉｖｅｎｅｓｏｆａｎｉｓｏ┐ｌａｔｅｄｌｅｆｔａｔｒｉｕｍｔｒｅａｔｅｄｗｉｔｈ３ａｄｒｅｎｅｒｇｉｃａｇｏｎｉｓｔｓｗｅｒｅｏｂｓｅｒｖｅｄｉｎｒａｔｓｗｉｔｈｈｅｍｏｒｒｈａｇｉｃｓｈｏｃｋ．Ｔｈｅ...

关键词： TRH-SENSI-TIZATION ADRENOC adrenoceptors

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Intermittent hypobaric hypoxia protects the heart against ischemia-reperfusion injury through activation of α1-adrenoceptors

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中国病理生理杂志 2012年第11期 2020-2021页

作者： GAO Ling1,CHEN Le1,LU Zhi-zhen2,ZHANG You-yi 2,ZHANG Cai-mei1,CHEN Yi-xiong1,YANG Huang-tian1(1Key Laboratory of Stem Cell Biology and Laboratory of Molecular Cardiology,Institute of Health Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200025,China 2Institute of Vascular Medicine,Peking University Third Hospital & Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education,Beijing 100191,China)

AIM:Cumulated evidence have shown that intermittent hypobaric hypoxia(IHH)can protect the heart against ischemia-reper-fusion(I/R)injury by improving major manifestations such as infarct size,post-ischemic contractile... 详细信息

关键词： Intermittent hypobaric hypoxia protects the heart against ischemia-reperfusion injury through activation of adrenoceptors AIM MMP

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PGE2Generation in Myocardium from Isolated Rat Atrium under Hypoxia and Reoxygenation Conditions. Effect of Anti-β1IgG from Patients with Chronic Severe Periodontitis

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Pharmacology & Pharmacy 2014年第2期5卷 204-215页

作者： Sabrina Ganzinelli Silvia Reina Mirian Matoso Germán González Celina Morales Enri Borda Institute of Cardiovascular Physiopathology School of Medicine University of Buenos Aires Buenos Aires Argentina National Research Council of Argentina (CON-ICET) Buenos Aires Argentina Institute of Cardiovascular Physiopathology School of Med-icine University of Buenos Aires Buenos Aires Argentina Pharmacology Unit School of Dentistry Uni-versity of Buenos Aires Buenos Aires Argentina National Research Council of Argentina (CON-ICET) Buenos Aires Argentina

Background: Hypoxia is one of the most frequently encountered stresses in health and disease. Methods: We compared the effects of an anti-β1 periodontal IgG (pIgG) and an authentic β1 adrenergic agonist, xamoterol, on isolated myocardium from rat atria contractility. We used an ELISA assay to measure the generation of PGE2 in vitro after the addition of either the antibody or the adrenergic agonist. We analyzed the myocardium histopathologically in the presence of both the antibody and/or the adrenergic agonist drug during normoxia, hypoxia and reperfusion conditions. Results: PGE2 generation increased during the hypoxia and was unchanged during reoxygenation period compared with the production of this prostanoid in atria during normoxia condition. A β1 specific adrenoceptor antagonist atenolol and the β1 synthetic peptide abrogated the increment of the prostanoid in the presence of pIgG but only atenolol due to it in the presence of xamoterol. The increment of PGE2 was dependent on the activation of cox-1 and cox-2 isoforms. Moreover, cox-2 was more active and produced more increments in the production of PGE2 in the presence of the pIgG than cox-1 activation. Histopathologically, studies of myocardium specimens during these different periods of the experimental protocol: basal (B), hypoxia (H) and reoxygenation (R), were also performed and showed tissue necrosis and edematization at the myocardium level. Conclusion: The phenomenon studied here supports the notion that PGE2 may be responsible for tissue edematization. PGE2 maybe acts as a beneficial modulator in the myocardium and prevents a major injury of it. The inflammation damage to the heart organ and cardiomyocytes caused by the actions of the antibodies in the course of heart lesions provoked by cardiovascular autoimmune disease, explains some of these results obtained in the present experiments. Further studies will be needed to establish the real role of PGE2 during hypoxia injury of the heart in the cour

关键词： Myocardium PGE2 Hypoxia Histopathology Periodontitis Antibodies Anti-β1 adrenoceptors Xamoterol

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Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus

Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of ...

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中国睡眠研究会第九届学术年会

作者： Nian Yang Qi-Cheng Qiao Yu-Hui Liu Ji-Qiang Zhang Zhi-An Hu Jun Zhang

The central noradrenergic system participates in di- verse nervous ***,our knowledge of the action of adrenoceptors in motor regulation is still ***,reticulospinal neurons in the caudal pontine re- ticular nucleus(PnC) receive fairly dense noradrenergic inner- vation and play an important role in motor ***,after demonstrating the expression of al- and ct2-adrenoceptors in the PnC,we found that noradrenaline elicited a post-synaptic effect(inward or outward whole-cell current at-70 mV hold- ing) on PnC reticulospinal *** α1- and α2- adrenoceptors were co-expressed in individual PnC reticulospinal neurons to mediate an inward and an outward current component at-70 mV holding,respectively,which,when superposed,produced the overall post-synaptic effects of noradrenaline(NA).More importantly,the activation of post-synaptic al- or a2-adrenoceptors indeed exerted oppos- ing modulations(excitation ***) on the firing activ- ities of individual PnC reticulospinal ***,the activation and inhibition of the Na-permeable nonselective cationic conductance(NSCC) were demonstrated to be coupled to al- and a2-adrenoceptors,***,the activation of a2-adrenoceptors activated K ***-synaptically,the a2-adrenoceptors were expressed to attenuate the miniature excitatory postsynaptic current(mEPSC) in PnC reticulospinal neurons,but not to affect the miniature inhibitory postsynaptic current(mlPSC).Consistently,the evoked EPSC in PnC reticulospinal neurons was suppressed after the activation of pre-synaptic a2- ***,the excitatory input and post-synaptic dynamics of PnC reticulospinal neurons are indeed intricately modulated by the activation of aland a2-adrenoceptors,through which motor control may be regulated in an adaptive manner by the central noradrenergic system.

关键词： Noradrenaline adrenoceptors NSCC Caudal pontine reticular nucleus Reticulospinal neurons Motor control Mol Neurobiol

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