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Effect of noise exposure(85 dB) on testicular adrenocortical steroidogenic key enzymes, acid and alkaline phosphatase activities of sex organs in mature albino rats

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Journal of Environmental Sciences 2000年第3期12卷 286-289页

作者： Debidas Ghosh, Sampa Ghosh, Sandip Chattopadhyay, Jogen Debnath (Department of Human Physiology with Community Health, Vidyasagar University, Midnapore\|721 102, West Bengal, India) Department of Human Physiology with Community Health Vidyasagar University Midnapore-721 102 West Bengal India

Changes in the activities of Δ 5\|3β\|hydroysteroid dehydrogenase(HSD) in testis and adrenal gland, 17β\|hydroxysteroid dehydrogenase in testis, acid and alkaline phosphatase in testis, prostate and seminal vesicle were observed in noise exposed mature rats at the intensity of 85 dB for 8 h/day for 45 days. The results indicated that noise exposed group showed a significant diminution in the activities of androgenic key enzymes Δ 5\|3β and 17β\|HSD, acid phosphatase in testis, prostate and seminal vesicle. There was a significant elevation in the activities of adrenal Δ 5\|3β\|HSD, alkaline phosphatase in testis and other accessory sex organ in noise exposed group. Gonadosomatic, prostatosomatic and seminal vesiculo\|somatic indexes were decreased significantly in noise exposed group. Therefore, it is evident that noise exposure at 85dB exerts a deleterious effect on testicular and adrenocortical activities.

关键词： noise hydroxysteroid dehydrogenase acid phosphatase alkaline phosphatase sex organs adrenal cortex

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小儿肾上腺皮质癌

中华小儿外科杂志 1982年第01期3卷 13-15页

作者：黄澄如贺荣友北京儿童医院外科

adrenal carcinoma is often responsible for Cushing's syndrome complicated with virilization or isosexual precocity in a *** the carcinoma is large enough to be palpable on examination and can be demonstrated by routine *** level of urinary 17-ketosteroids or 17-hydroxycorticoids and the failure to respond to the dexamethasone suppresion test strongly support the diagnosis of *** patients,two males and two females,with adrenal carcinoma were admitted to this hospital from 1960 to 19799 with the age ranging from 2 to 4 years.

关键词：小儿肾上腺皮质癌 Children adrenal cortex carcinoma dexamethasone diagnosis of 随访术后死亡手术切除婴幼儿皮质醇功能性 two 1979年 level 讨论病变 test age

Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy

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World Journal of Cardiology 2017年第3期9卷 200-206页

作者： Anastasios Lymperopoulos Beatrix Aukszi Department of Pharmaceutical Sciences College of Pharmacy Nova Southeastern University Department of Chemistry and Physics Hal-mos College of Natural Sciences and Oceanography Nova Southeastern University

Aldosterone mediates many of the physiological and pathophysiological/cardio-toxic effects of angiotensin II(Ang II). Its synthesis and secretion from the zona glomerulosa cells of the adrenal cortex, elevated in chronic heart failure(HF), is induced by Ang II type 1 receptors(AT1Rs). The AT1R is a G protein-coupled receptor, mainly coupling to Gq/11 proteins. However, it can also signal through β-arrestin-1(βarr1) or-2(βarr2), both of which mediate G protein-independent signaling. Over the past decade, a second, Gq/11 proteinindependent but βarr1-dependent signaling pathway emanating from the adrenocortical AT1R and leading to aldosterone production has become appreciated. Thus, it became apparent that AT1R antagonists that block both pathways equally well are warranted for fully effective aldosterone suppression in HF. This spurred the comparison of all of the currently marketed angiotensin receptor blockers(ARBs, AT1R antagonists or sartans) at blocking activation of the two signaling modes(G protein-, and βarr1-dependent) at the Ang IIactivated AT1R and hence, at suppression of aldosterone in vitro and in vivo. Although all agents are very potent inhibitors of G protein activation at the AT1R, candesartan and valsartan were uncovered to be the most potent ARBs at blocking βarr activation by Ang II and at suppressing aldosterone in vitro and in vivo in post-myocardial infarction HF animals. In contrast, irbesartan and losartan are virtually G protein-"biased" blockers at the human AT1R, with very low efficacy for βarr inhibition and aldosterone suppression. Therefore, candesartan and valsartan(and other, structurally similar compounds) may be the most preferred ARB agents for HF pharmacotherapy, as well as for treatment of other conditions characterized by elevated aldosterone.

关键词： adrenal cortex Adrenocortical zona glomeru losa cell Aldosterone Angiotensin receptor blocker Angiotensin II type 1 receptor β-arrestin-1 Heart failure Suppression efficacy

Corticosurrenaloma: About a Pediatric Case

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Open Journal of Pediatrics 2022年第2期12卷 449-452页

作者： Thierry Mukenge Wa Mukengeshay Fatoumata Binta Balde Zineb Benmassaoud Priscilla Kinsala Othmane Allaoui Abdelhalim Mahmoudi Khalid Khattala Sara Benmilloud Youssef Bouabdallah Service de Chirurgie Pédiatrique Centre Hospitalier et Universitaire Hassan II de Fès Fès Morocco Service de Pédiatrie Unité d’Oncologie Centre Hospitalier et Universitaire Hassan II de Fès Fès Morocco Faculté de Médecine et de Pharmacie Université Sidi Mohamed Ben Abdallah de Fès Fès Morocco

Introduction: This study aims to describe the outcome of adrenocortical cancer in children through observation. Observation: A 10-year-old girl with no previous pathological history. She presented headaches and severe hypertension with clinical and biological signs of hyperandrogenism for 6 months. An abdominal CT scan showed an encapsulated left adrenal mass without local or regional invasion or secondary location. A pheochromocytoma or adrenal neuroblastoma was first suspected. The blood pressure was stable at 130/65 mmHg under antihypertensive drugs. She underwent a complete tumor resection without any intraoperative incident. The pathologic study confirmed the adrenocortical carcinoma scored Weiss 7. The severe high blood pressure reappeared 2-year later despite antihypertensive drugs. The thoracic abdominal and pelvic CT scan showed a locally advanced tumor recurrence in the left adrenal gland with parenchymal nodes in the lungs and liver. The outcome was fatal despite medical and surgical management. Conclusion: Adrenocortical cancer is a rare tumor. It is important to hormonal testing in the presence of Cushing’s syndrome in children. It can give a strong indication of the diagnostic possibilities. Histology confirms the diagnosis. The evolution is covered by complications, in particular recurrence with life-threatening metastases.

关键词： adrenal Tumor adrenal cortex Hyperandrogenism Child

112名运动员尿17-羟、17-酮调查及3年追踪观察

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中国运动医学杂志 1987年第4期 200-202+253-254页

作者：张秀云僧松岑郑州市第五人民医院河南省体育科研所

作者对8个项目112名运动员进行了尿17羟皮质类固醇、17—酮类固醇24小时排量的检查。结果表明:运动员的肾上腺皮质分泌功能均大于正常对照组,差异有显著性。另外,随运动项目和训练年限的不同,肾上腺皮质分泌功能亦有差异。

关键词： 17-OHCS 17-KS adrenal cortex physical exercise