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Exacerbation of chronic inflammatory diseases by infectious agents:Fact or fiction?

World Journal of Diabetes 2010年第2期1卷 27-35页

作者： Bernhard Kaltenboeck Department of Pathobiology College of Veterinary MedicineAuburn University

Chronic inflammatory diseases caused by obesity represent critical public health concerns worldwide. In these diseases such as metabolic syndrome,diabetes and atherosclerosis,adipose tissue acts as an endocrine organ that releases large quantities of inflammatory mediators into *** classically recognized effectors on the development of obesity and resultant conditions,infection has attracted attention as an enhancer of chronic inflammatory *** diseases have long been associated with obesity,metabolic syndrome,diabetes and ***,the infectious hypothesis for chronic inflammatory diseases has been challenged by inconclusive clinical ***,the large body of evidence accumulated over decades on the association of infectious diseases with obesity,diabetes and cardiovascular disease should not be ***,re-formulation of hypothesesof the mechanisms by which microbes affect obesityassociated diseases may be required with an emphasis on the early events in the progression of such diseases and the multifactorial nature of pathogen-host *** review focuses on pathogens that directly promote obesity and on pathogens that cause chronic infections and thereby enhance metabolic diseases in obese patients.A new perspective on the interaction between infections and obesity-related diseases may improve management of chronic inflammatory diseases that rank high among global threats to human health.

关键词： Chronic inflammatory diseases Obesity Diabetes adenovirus-36 Chlamydia pneumoniae

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