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adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study

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Cancer Biology & Medicine 2013年第1期10卷 52-54页

作者： Chi Zhao Jin-Zhong Liu Shu-Bin Wang Shi-Chang Wang Zhengzhou University School and Hospital of Stomatology Department of Pathology The Fourth Affiliated Hospital of Zhengzhou University Department of Oral and Maxillofacial Surgery The Fourth Affiliated Hospital of Zhengzhou University

Gingival adenoid cystic carcinoma (ACC) is a rare malignancy. We describe the diagnosis and treatment of a 43 year- old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

关键词： Gingival maxilla adenoid cystic carcinoma immunohistochemistry

adenoid cystic carcinoma of trachea： a case report and review of literature

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Chinese Medical Journal 2012年第12期125卷 2238-2239页

作者： LI Wen HUA Wen YAN Fu-gui SHEN Hua-hao XU Hao Department of Respiratory Medicine Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China

Primary tracheal tumors are relatively rare. Here we report one case of primary adenoid cystic carcinoma of the trachea which was ever misdiagnosed as asthma and hysteria. In this case, the pulmonary function test was normal, and firstly no obvious abnormalities were found in laryngoscopy, bronchoscopy and CT scan of chest. Later a sagittal and coronal reconstruction CT scan of trachea showed a mass situated in the subglottic trachea. Lastly a laryngoscopy was again done after a tracheal incision and showed a small mass in the posterior wall of the subglottic trachea, and tumor ablation was performed. In addition, we reviewed the literature of primary tracheal tumors and summarized the epidemiology, presenting features, available therapeutic options of the disease.

关键词： adenoid cystic carcinoma trachea diagnosis therapy

Preliminary proteomic analysis of human tears in lacrimal adenoid cystic carcinoma and pleomorphic adenoma

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 841-848页

作者： Han Yue Feng-Xi Meng Rui Zhang Jiang Qian Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031China

·AIM: To detect proteomic differences in tears between adenoid cystic carcinoma(ACC) and pleomorphic adenoma(PA).·METHODS: Tear samples were collected from 4 patients with ACC, 5 with PA, and 4 control cases. Label-free analysis and parallel reaction monitoring(PRM) were used to screen and validate the tear proteome. Gene Ontology(GO) annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG) were conducted for bioinformatics analysis.·RESULTS: In total, 1059 proteins in tear samples were identified by label-free analysis. Between ACC and PA, 415 differentially expressed proteins were detected. Based on the GO annotation, enzyme regulator activity and serinetype endopeptidase inhibitor activity in the molecular function category, blood microparticle and extracellular matrix in the cellular component category, and response to nutrient levels in the biological process category were most predominant. By KEGG pathway annotation, the different proteins between ACC and PA mainly par ticipated in complement and coagulation cascades, amoebiasis, African trypanosomiasis and cholesterol metabolism. Eight proteins with mostly significant differences were verified by PRM, and five proteins with more than 10-fold increases in ACC compared with PA, including integrin β, α-2-macroglobulin, epididymal secretory sperm binding protein Li 78p, RAB5C, and complement C5, were identified.·CONCLUSION: The combined tools of label-free analysis and PRM are very effective and efficient, especially for samples such as tears. Some proteomic dif ferences in tears between ACC and PA are identified and these protein candidates may be specific biomarkers for future exploration.

关键词： adenoid cystic carcinoma pleomorphic adenoma tear proteome

Rapid response to radiotherapy in unresectable tracheal adenoid cystic carcinoma:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9535-9541页

作者： Qiang Wu Feng Xu Lung Cancer Center and Institute West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND adenoid cystic carcinoma(ACC)occurs mainly in the head and *** ACC(TACC)is *** resection is recommended as the main treatment of choice,and radiotherapy is considered for residual disease in the postoperative *** radiotherapy is an alternative approach to cure unresectable *** the status of radiosensitivity in TACC is uncertain,the evidence for radiotherapy in unresectable TACC is not well established,especially in terms of the optimal dosage and its response ***,we report a case of locally advanced *** SUMMARY A 49-year-old woman was diagnosed with TACC,which included a range of lesions arising in the upper trachea extending caudally 2 cm to 7 cm of the *** was treated with definitive radiotherapy,given the low likelihood of complete resection of the *** to the indolent growth and the propensity for infiltration along the airways,the scheduled radiation dose of 76 Gy in 38 fractions with 6-MV X-ray delivered by intensity-modulated radiotherapy was conducted to the primary tumor *** irradiation of 40 Gy,the patient’s dyspnea on exertion was dramatically relieved and bronchoscopy revealed that the previous large polypoid intra-luminal mass was significantly eliminated,with near-complete *** patient completed two phases of scheduled radiotherapy,and acute reactions to treatment included subjective chest tightness and grade 2 esophagitis,managed *** 5 years of treatment,the patient is alive without recurrent disease,and there were no serious late radiation esophagus and lung damage,with only slight dysphagia without perforation and *** Taken together,TACC is uncommon and the treatment of unresectable TACC is *** case indicated that patients with unresectable TACC who rapidly respond to radiation may benefit from primary radical *** may be considered an effective alternative treatment modality.

关键词： adenoid cystic carcinoma Tracheal cancer Radiotherapy Tracheal adenoid cystic carcinoma Case report

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 547-553页

作者： Rui Liu Ji-Tong Shi Xin Ge Ben-Tao Yang Hong Zhang Jing-Xue Zhang Jian-Min Ma Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China

AIM:To evaluate the survival outcomes of patients with lacrimal gland adenoid cystic carcinoma who underwent eye-sparing surgery combined with ^(125I)seed implantation radiotherapy or local externalγ-ray ***:In this retrospective comparative case series,the clinical records of 27 primary and 8 recurrent patients were *** and multivariate analyses were used to identify risk factors associated with distant metastasis(DM),and the overall survival(OS)after the initial surgery was ***:The median follow-up after radiotherapy was 36 mo(range 6-120 mo).At the last follow-up after radiotherapy,26(74.3%)patients had no evidence of disease,7(20%)patients had DM,2(5.9%)patients died of DM,and 1 patient with DM was lost to *** analyses showed that duration of symptoms,bone destruction,T stage classification,and wide excision surgery were risk factors influencing DM(P<0.05).The 5-year and 10-year OS rates after the initial surgery were 95.8%and 79.9%,*** 5-year DM-free survival and disease-free survival rates after radiotherapy were 66.4%and 52.7%,***:^(125I)seed radiotherapy and local externalγ-ray radiotherapy may have similar therapeutic effects in preventing *** with T1/T2 stage disease have a better prognosis than those with T3/T4 stage disease.

关键词： adenoid cystic carcinoma lacrimal gland ^(125I)seed radiotherapy γ-ray radiotherapy surgical excision

Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5238-5244页

作者： Xiao-Hong Li Yu-Tao Zhang Hao Feng Department of Pathology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina Department of Radiology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina

BACKGROUND adenoid cystic carcinoma(ACC)is a common malignant tumor of salivary *** lung and liver are frequent sites of distant *** metastasis as the initial clinical manifestation of sublingual gland ACC is very *** SUMMARY A 51-year-old Chinese woman presented with a painless mass in the right lobe of *** tumor was composed of ductal cells and myoepithelial cells with a morphology including tubiform and cribriform *** results showed ductal cells positive for CK7,CK14,CK19,CD117,and 34βE12,and negative for MYB,vimentin,ER,PR,and *** myoepithelial cells were positive for p63,calponin and CK5/*** salivary ACC was considered,and a sublingual gland mass was revealed by computed *** evaluation confirmed primary sublingual gland *** in situ hybridization(FISH)did not find an MYB-NFIB fusion gene in specimens from either the primary or metastatic ACC *** sublingual gland ACC relapsed in 20 *** recurrent lesion disappeared following local radiation therapy and computed tomography-guided radioactive seed *** patient remains in good condition until *** Metastatic sublingual gland ACC with initial clinical manifestation as a liver mass is very rare,and was pathologically confirmed in this patient by its histological *** hepatic tumors and metastatic carcinomas should be included in the differential *** detection of MYB protein and MYB-NFIB fusion gene detection by FISH can be helpful,but occasional negative results confuse the diagnosis.

关键词： Liver metastasis adenoid cystic carcinoma Sublingual gland Differential diagnosis Immunohistochemistry Fluorescence in situ hybridization Case report

adenoid cystic carcinoma of the Head and Neck:Epidemiology and Predictors of Prognosis

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第5期2卷 165-173页

作者： Daniel Monteiro Joao Lino Teresa Bernardo Joao Fernandes Eurico Monteiro Department of Otorhinolaryngology and Head and Neck Surgery Saint Antonio HospitalPortoPortugal Department of Otorhinolaryngology and Head and Neck Surgery Portuguese Institute of OncologyPortoPortugal

Objectives: The biologic behavior of the adenoid cystic carcinoma (ACC) and the factors predicting outcome for these tumors are still poorly understood. Our objective is to analyze the predicting factors and the value of different treatment possibilities, since none sole treatment has been standardized. Methods: A retrospective analysis of the epidemiologic, clinical and histologic aspects of ACC, as well as treatment options and other prognostic factors of all the cases of ACC of the head and neck treated at this Institution were analyzed. From 1974 until 2011, 152 patients were diagnosed with ACC and treated at the Portuguese Institute of Oncology (Porto Centre). Main outcome measures: overall survival, local recurrence and distant metastasis were calculated by the Kaplan-Meier method. Factors predictive of outcome were identified by univariate and multivariate analysis. Results: The mean age at diagnosis was 55.8 years (range, 19-83 years). Incidence was higher in the female population, with a female to male ratio of 1.7:1 respectively. The primary tumor location was hard palate and submandibular region in 56 cases, 28 in each location (24.6%), parotid gland (17 cases, 14.9%) and oral cavity excluding palate (16 cases, 14%).Distributions according to T stage were: T1 (29.8%);T2 (30.7%);T3 (17.5%);T4 (22%). The overall 1-year, 5-year and 10-year survival for all patients were 94.6%, 60.5%, 41.6%, respectively. Conclusions: Univariate survival analysis revealed that age older than 60 years (p = 0.002), solid histologic subtype (p = 0.042), advanced clinical stage (p p = 0.036) were correlated with a poor survival. Multivariate analysis confirmed that age and advanced clinical stage were worst independent predicators of overall survival as well as perineural invasion for local recurrence and distant metastasis. In our analysis, radiotherapy did not have a relevant impact on survival, except in cases of solid histologic subtype. To analyze distant metastatic capacity

关键词： adenoid cystic carcinoma Head and Neck Cancer Prognostic Factors

Effects of Genistein on Proliferation and Cell Cycle of Salivary adenoid cystic carcinoma Cells

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Chinese Journal of Cancer Research 2007年第1期19卷 64-67页

作者：马杰王洁钟鸣王兆元 Department of Oral Medicine the Second Affiliated HospitaL China Medical University Department of Pathology College of Stomatology China Medical University

Objective： To investigate the growth inhibiting effect of tyrosine protein kinase inhibitor, genistein, on human salivary adenoid cystic carcinoma SACC-83 cell line in vitro, and its effects on the expression of CyclinB1 protein and cell cycle. Methods： Effects of genistein on the growth of SACC-83 cells in vitro were measured with MTr assay. Cell cycle was detected with flow cytometry. The expressions of CyclinB1 and Cdkl proteins were measured with Western blot method, and the results of protein expression were quantitatively analyzed by FluorChem V2.0 software. The results were statistically analyzed by SPSSI 1.5 software. Results： Genistein inhibited the cell proliferation in a dose-dependant and time-dependant manner. The genistein-treated SACC-83 cells were arrested in the G2/M phase and had lower contents of CyclinB1 and Cdkl proteins compared with the control group. Conclusion： The growth inhibiting effect of genistein on SACC-83 cells may be associated with the regulations of genistein on the CyclinB1 and Cdk1 protein expressions and the cell cycle.

关键词： adenoid cystic carcinoma Genistein CyclinB1 Cell cycle

Effect of Exogenous bFGF on the Proliferation of Human adenoid cystic carcinoma ACC-2 Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第2期28卷 227-229页

作者：丁蕾朱声荣谢三祥吴祥冰 Department of Stomatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030 China

To observe the effects of basic fibroblast growth factor （bFGF） on human adenoid cystic carcinoma ACC-2 cell line proliferation and ERK, cyclin D1/p21^waf/cip1 signaling pathways, human adenoid cystic carcinoma cells （ACC-2） were cultured and the influence of bFGF of different concentrations on cell proliferation was determined by MTT. Protein was detected by immuno-precipitation and ERK activity by using ERK agent kit. p-ERK1/2 and down-stream cyclin D1, p21^waf/cip1 expression were detected by Western blotting and the interfering role of mitogen protein-activated kinase （MEK） suppressor U0126 in the afore-mentioned indicators was examined. MTT demonstrated ACC-2 cell proliferation was substantially enhanced by bFGF, immuo-precipitation displayed ERK activity was up-regulated by bFGF, and immuno-imprinting also showed p-ERK1/2, cyclin D1 expression was greatly enhanced and p21^waf/cip1 expression was inhibited by bFGE U0126 suppressed the effect of bFGF. It is concluded that bFGF can promote the proliferation of human adenoid cystic carcinoma ACC-2 cells, and its pathways are associated with the up-regulated activity and expression of p-ERK1/2, inhibited p21waf/cip1 expression and enhanced cyclin D1 expression.

关键词： basic fibroblast growth factor adenoid cystic carcinoma extracellular signal-regulated kinase cell cycle phase protein D1