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Radiomic features from computed tomography to differentiate invasive pulmonary adenocarcinomas from non-invasive pulmonary adenocarcinomas appearing as part-solid groundglass nodules

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Chinese Journal of Cancer Research 2019年第2期31卷 329-338页

作者： Ting Luo Ke Xu Zheng Zhang Lina Zhang Shandong Wu Department of Radiology the First Affiliated Hospital of China Medical University Departments of Radiology Biomedical Informatics Bioengineering and Intelligent Systems University of Pittsburgh

Objective:We aim to investigate radiomic imaging features extracted in computed tomography(CT)images to differentiate invasive pulmonary adenocarcinomas(IPAs)from non-IPAs appearing as part-solid ground-glass nodules(GGNs),and to incorporate significant radiomic features with other clinically-assessed features to develop a diagnostic nomogram model for ***:This retrospective study was performed,with Institutional Review Board approval,on 88 patients with a total of 100 part-solid nodules(56 IPAs and 44 non-IPAs)that were surgically confirmed between February 2014and November 2016 in the First Affiliated Hospital of China Medical *** radiomic features were computed automatically on 3D nodule volume segmented from arterial-phase contrast-enhanced CT images.A set of regular risk factors and visually-assessed qualitative CT imaging features were compared with the radiomic features using logistic regression *** diagnostic models,i.e.,a basis model using the clinical factors and qualitative CT features,a radiomics model using significant radiomic features,and a nomogram model combining all significant features,were built and compared in terms of receiver operating characteristic(ROC)*** curve analysis was performed for the nomogram model to explore its potential clinical ***:In addition to three visually-assessed qualitative imaging features,another three quantitative features selected from hundreds of radiomic features were found to be significantly(all P<0.05)associated with *** diagnostic nomogram model showed a significantly higher performance[area under the ROC curve(AUC)=0.903]in differentiating IPAs from non-IPAs than either the basis model(AUC=0.853,P=0.0009)or the radiomics model(AUC=0.769,P<0.0001).Decision curve analysis indicates a potential benefit of using such a nomogram model in clinical ***:Quantitative radiomic features provide additional information over clinically-as

关键词： Radiomics lung adenocarcinomas tomography X-ray computed

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Applying comprehensive histologic assessment and genetic testing to synchronous multifocal lung adenocarcinomas and further survival analysis

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Chinese Medical Journal 2019年第2期132卷 227-231页

作者： Fei Xiao Zhen-Rong Zhang Xiao-Wei Wang De-Ruo Liu Yong-Qing GUO Bin Shi Zhi-Yi Song Chao-Yang Liang National Clinical Research Center for Respiratory Diseases Center for Respiratory DiseasesDepartment of Thoracic SurgeryChina-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China

To the Editor:The differentiation of multiple primary lung adenocarcinomas (MPLAs) from metastases is important to allow for proper clinical management and prognostic *** current revised diagnostic criteria for MPLAs proposed by the American College of Chest Physicians (ACCP) have been commonly applied since 2003.[1] However, it remains technically challenging to determine whether 2 or more lung adenocarcinomas from the same patient are *** approaches and algorithms including gene mutation analysis addressing this problem have been described.[2,3] Here, we present a cohort of 45 patients with synchronous multifocal lung adenocarcinomas.

关键词： differentiation adenocarcinomas prognostic prediction

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adenocarcinomas after Prophylactic Surgery for Familial Adenomatous Polyposis

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Journal of Cancer Therapy 2013年第1期4卷 260-270页

作者： Joan C.Smith Michael W.Schaffer Billy R.Ballard Duane T.Smoot Alan J.Herline Samuel E.Adunyah Amosy E.M’Koma Laboratory of Inflammatory Bowel Disease Research Division of Biomedical SciencesDepartment of Biochemistry and Cancer BiologyMeharry Medical College School of MedicineNashvilleTennessee Department of Pathology Meharry Medical School of MedicineNashvilleTennessee Department of Internal Medicine Meharry Medical College School of MedicineNashvilleTennessee Department of General Surgery Vanderbilt University School of MedicineNashvilleTennessee Vanderbilt-Ingram Cancer Center Vanderbilt University School of MedicineNashvilleTennessee.

The incidence of familial adenomatous polyposis (FAP) is one in 7,000 to 12,000 live births. Virtually, all surgically untreated patients with FAP inevitably develop colorectal-cancer in their lifetime because they carry the adenomatous polyposis coli gene. Thus prophylactic proctocolectomy is indicated. Surgical treatment of FAP is still controversial. There are however, four surgical options: ileorectal anastomosis, restorative proctocolectomy with ileal pouch-anal anastomosis, proctocolectomy with ileostomy, and proctocolectomy with continent-ileostomy. Conventional proctocolectomy options largely lie between colectomy with ileorectal anastomosis or ileal pouch-anal anastomosis. Detractors of ileal pouch-anal anastomosis prefer ileorectal anastomosis because of better functional results and quality of life. The functional outcome of total colectomy with ileorectal anastomosis is undoubtedly far superior to that of the ileoanal pouch;however, the risk for rectal cancer is increased by 30%. Even after mucosectomy, inadvertent small mucosal residual islands remain. These residual islands carry the potential for the development of subsequent malignancy. We reviewed the literature (1975-2012) on the incidence, nature, and possible etiology of subsequent ileal-pouch and anal transit zone adenocarcinoma after prophylactic surgery procedure for FAP. To date there are 24 studies reporting 92 pouch-related cancers;15 case reports, 4 prospective and 5 retrospective studies. Twenty three of 92 cancers (25%) developed in the pouch mucosa and 69 (75%) in anal transit zone (ATZ). Current recommendation for pouch surveillance and treatment are presented. Data suggest lifetime surveillance of these patients.

关键词： Familial Adenomatous Polyposis Restorative Proctocolectomy Ileal Pouch-Anal Anastomosis Ileorectal Anastomosis adenocarcinomas

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Surgical treatment of familial adenomatous polyposis: Dilemmas and current recommendations

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World Journal of Gastroenterology 2014年第44期20卷 16620-16629页

作者： Fábio Guilherme Campos Department of Gastroenterology Colorectal Surgery Division Hospital das Clínicas University of So Paulo Medical School

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited syndrome characterized by multiple adenomatous polyps (predisposing to colorectal cancer development) and numerous extracolonic manifestations. The underlying genetic burden generates variable clinical features that may influence operative management. As a precancerous hereditary condition, the rationale of performing a prophylactic surgery is a mainstay of FAP management. The purpose of the present paper is to bring up many controversial aspects regarding surgical treatment for FAP, and to discuss the results and perspectives of the operative choices and approaches. Preferably, the decision-making process should not be limited to the conventional confrontation of pros and cons of ileorectal anastomosis or restorative proctocolectomy. A wide discussion with the patient may evaluate issues such as age, genotype, family history, sphincter function, the presence or risk of desmoid disease, potential complications of each procedure and chances of postoperative surveillance. Therefore, the definition of the best moment and the choice of appropriate procedure constitute an individual decision that must take into consideration patient’s preferences and full information about the complex nature of the disease. All these facts reinforce the idea that FAP patients should be managed by experienced surgeons working in specialized centers to achieve the best immediate and long-term results.

关键词： Familial adenomatous polyposis Surgical treatment Restorative proctocolectomy Ileal pouch-anal anastomosis Ileorectal anastomosis adenocarcinomas

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Analysis of 234 cases of colorectal polyps treated by endoscopic mucosal resection

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World Journal of Clinical Cases 2020年第21期8卷 5180-5187页

作者： Lu Yu Na Li Xiao-Mei Zhang Tao Wang Wei Chen Department of Gastroenterology Maanshan Central HospitalMaanshan 243000Anhui ProvinceChina Department of Gastroenterology Affiliated Hospital of Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Colorectal polyps refer to all neoplasms that protrude into the intestinal *** believe that 50%-70%of colorectal cancers originate from adenomatous *** To investigate the endoscopic morphologic features,pathologic types,and clinical situation;evaluate the efficacy and safety of endoscopic mucosal resection(EMR);and guide clinicians in their daily *** Two hundred thirty-four patients who underwent EMR in our hospital from January 1,2018 to December 31,2019 were *** including sex,age,endoscopic morphology of the polyps,and pathological characteristics were analyzed among *** A total of 295 polyps were resected from the 234 subjects enrolled in the study,of which 4(1.36%)were Yamada type *** were 75(25.42%)type II,101(34.24%)type III,and 115(38.98%)type IV *** them,41 were nonadenomas,110 were low-risk adenomas,139 were high-risk adenomas,and 5 were *** differences in distribution were not statistically significant,with P values greater than *** risk of cancer significantly increased for polyps≥1 cm in diameter(c2=199.825,P=0.00).Regarding the endoscopic morphological features,congestion,erosion,and lobulation were more common on the surface morphology of high-risk adenomas and cancerous polyps(c2=75.257,P=0.00),and most of them were Yamada types III and *** all,6 of the 295 polyps could not be removed completely,with a one-time resection rate of 97.97%.There were two cases of postoperative bleeding and no cases of perforation,with an overall complication rate of 0.09%.CONCLUSION Colorectal polyps ranging from non-adenomatous polyps,low-risk adenomas,and high-risk adenomas to adenocarcinomas each has their own endoscopic features,while EMR,as a mature intervention,has good safety and operability and should be promoted clinically,especially at the primary care level.

关键词： Colorectal polyp Endoscopic mucosal resection High-risk adenoma Risk factors adenocarcinomas 1,4-bis(diphenylphosphino)butane

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The Association between Mutations Detected in Tissue and Plasma from Patients with Colorectal Adenoma and Adenocarcinoma

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Journal of Cancer Therapy 2014年第14期5卷 1399-1401页

作者： Caroline Brenner Larsen Jan Lindebjerg Rikke Fredslund Andersen Niels Pallisgaard Susanne Holck Anders Jakobsen Hans Jorgen Nielsen Department of Oncology Vejle HospitalVejleDenmark Department of Pathology Vejle HospitalVejleDenmark Department of Biochemistry Vejle HospitalVejleDenmark Department of Pathology Copenhagen University HospitalCopenhagenDenmark Department of Surgical Gastroenterology Copenhagen University HospitalCopenhagenDenmark

Most colorectal cancers evolve through an adenoma-carcinoma sequence with mutations in the KRAS/BRAF pathway as an early event. Mutation analyses are usually performed on tissue samples, but during the last couple of years the same analysis in blood has been facilitated. Our aim was to investigate the correlation between BRAF/KRAS mutations in tissue and plasma from colorectal adenomas and adenocarcinomas. Out of 22 patients with adenomas 10 had a mutation in the tissue, but no mutations were detected in the plasma. In 10 of 26 adenocarcinomas a mutation was found in the tumor and in four of these, the mutation was also detected in the plasma. Our results confirm previous findings that mutated DNA in plasma can be detected in approximately 50%?of non-metastasized adenocarcinomas. The difference between adenomas and adenocarcinomas suggests that appearance of mutated DNA in plasma associates with invasion.

关键词： KRAS BRAF Adenomas adenocarcinomas Carcinogenic Development

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