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Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection

Virologica Sinica 2022年第3期37卷 408-417页

作者： Shuhui Liu Kaitao Zhao Xi Su Xiaoxiao Gao Yongxuan Yao Ranran Kong Yun Wang Chunchen Wu Mengji Lu Xinwen Chen Rongjuan Pei Center for Biosafety Mega-Science State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Thoracic Surgery The Second Affiliated Hospital of Medical SchoolXi'an Jiaotong UniversityXi'an710004China Department of Medicine Icahn School of Medicine at Mount SinaiNew York10029USA Institute of Virology University Hospital EssenUniversity of Duisburg-EssenEssen45147Germany Guangzhou Laboratory Guangzhou510005China Current address:Division of Infectious Diseases Department of MedicineIcahn School of Medicine at Mount SinaiNew York10029USA Current address:State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology School of Basic Medical SciencesWuhan UniversityWuhan430071China Current address:Henan Mental Hospital the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang453002China Current address:Joint Center of Translational Precision Medicine Guangzhou Institute of PediatricsGuangzhou Women and Children Medical CenterGuangzhou510623China Current address:Department of Laboratory Medicine Maternal and Child Health Hospital of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Hepatitis B virus(HBV)/Hepatitis C virus(HCV)coinfection is frequently observed because of the common infection *** the reciprocal inhibition exerted by HBV and HCV genomes,the coinfection of HBV and HCV is associated with more severe forms of liver ***,the complexity of viral interference and underlying pathological mechanism is still *** the demonstration of absence of direct viral interplay,some in vitro studies suggest the indirect effects of viral-host interaction on viral dominance ***,we comprehensively investigated the viral replication and host immune responses which might mediate the interference between viruses in HBV/HCV coinfected Huh7-NTCP cells and immunocompetent HCV human receptors transgenic ICR *** found that presence of HCV significantly inhibited HBV replication in vitro and in vivo irrespective of the coinfection order,while HBV did not affect HCV *** alteration was coincidently reproduced in coinfected *** addition to the participation of innate immune response,an involvement of HCV in up-regulating HBV-specific immune responses was described to facilitate HBV *** systems partially recapitulate HBV/HCV coinfection and unveil the uncharacterized adaptive anti-viral immune responses during coinfection,which renews the knowledge on the nature of indirect viral interaction during HBV/HCV coinfection.

关键词： Hepatitis B virus(HBV) Hepatitis C virus(HCV) Coinfection Viral-host interaction Immunocompetent mouse model adaptive immune responses

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