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acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients

World Journal of Gastrointestinal Oncology 2019年第10期11卷 887-897页

作者： Hiroaki Takaya Tadashi Namisaki Mitsuteru Kitade Naotaka Shimozato Kosuke Kaji Yuki Tsuji Keisuke Nakanishi Ryuichi Noguchi Yukihisa Fujinaga Yasuhiko Sawada Soichiro Saikawa Shinya Sato Hideto Kawaratani Kei Moriya Takemi Akahane Hitoshi Yoshiji Third Department of Internal Medicine Nara Medical University

BACKGROUND Early diagnosis of hepatocellular carcinoma(HCC)is necessary to improve the prognosis of ***,the currently available tumor biomarkers are insufficient for the early detection of *** is essential in fatty acid metabolic pathways.A recent study reported that a high level of acylcarnitine may serve as a useful biomarker for the early diagnosis of HCC in steatohepatitis(SH)*** contrast,another study reported that the level of acetylcarnitine(AC2)-one of the acylcarnitine species-in non-SH patients with HCC was decreased vs that reported in those without *** To investigate the usefulness of acylcarnitine as a biomarker for the early diagnosis of HCC in non-SH *** Thirty-three non-SH patients(14 with HCC and 19 without HCC)were enrolled in this *** samples were obtained from patients at the time of *** levels of acylcarnitine and AC2 in the serum were determined through tandem mass *** levels of vascular endothelial growth factor(VEGF)and VEGF receptor 2(VEGFR-2)were determined by enzymelinked immunosorbent *** and multivariate analyses were used to determine early diagnostic factors of *** The level of acylcarnitine was significantly lower in non-SH patients with HCC vs those without HCC(Pacylcarnitine was the only independent factor for the early diagnosis of *** patients with a low level of AC2 had a significantly higher level of VEGF vs those with a high level of AC2(P<0.05).CONCLUSION The metabolic pathways of fatty acids may differ between SH HCC and non-SH HCC

关键词： acylcarnitine Acetylcarnitine Biomarker Hepatocellular carcinoma Angiogenesis Carnitine palmitoyltransferase 1 Oxidative stress

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Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang State Key Laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan Laboratory for Shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

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Metabolic and biological changes in children with obesity and diabetes

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World Journal of Meta-Analysis 2021年第2期9卷 153-163页

作者： Shirou Matsumoto Tomomi Nakamura Fusa Nagamatsu Jun Kido Rieko Sakamoto Kimotoshi Nakamura Department of Pediatrics Faculty of Medical SciencesKumamoto UniversityKumamoto 860-8556Japan Department of Perinatal Care Unit Kumamoto University HospitalKumamoto UniversityKumamoto 860-8556Japan

The World Health Organization has stated that obesity in childhood is one of themost serious public health challenges of the 21st century. Overweightness andobesity in early childhood lead to a higher risk of overweightness and obesity inadulthood, thus conferring an increased risk of chronic inflammatory conditions,including type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fattyliver disease, and some cancers. Therefore, metabolome analysis, targeted atscreening and intervening in childhood obesity, is very important. Recent studieshave indicated that amino acid and lipid metabolism could influence metabolicpathways in children with obesity. For this review, we searched clinical dataaddressing metabolomic profiles and insulin resistance (IR) in children withobesity from inception to February 2021 in Medline, Web of Science, and *** to our search, branched-chain amino acids (BCAAs), aromatic aminoacids, and acylcarnitines have reportedly been associated with IR as biomarkersfor diabetes in children. BCAAs, tyrosine, and phenylalanine could be predictorsof the future development of diabetes in nondiabetic subjects. In addition, it iswell known that insulin regulates BCAA metabolism, and BCAA is a biomarkerfor IR. To interpret the mechanism behind metabolic changes in obesity, it is veryimportant to understand the pathways and combinations related with amino acid,lipid and glucose metabolism. In this review, we summarize studies on metabolicchanges to understand metabolomics in children with obesity.

关键词： Children with obesity Diabetes mellitus Insulin resistance Amino acids acylcarnitine Metabolomics

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