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Fatty acid metabolism and acyl-coa synthetases in the liver-gut axis

World Journal of Hepatology 2021年第11期13卷 1512-1533页

作者： Yunxia Ma Miljana Nenkov Yuan Chen Adrian T Press Elke Kaemmerer Nikolaus Gassler Section Pathology Institute of Forensic MedicineJena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Anesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Pediatrics Jena University HospitalFriedrich Schiller University JenaJena 07747Germany

Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid *** acyl-coa synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological *** evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and *** this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty ***,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are ***,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.

关键词： Long-chain fatty acids Short-chain fatty acids acyl-coa synthetases Microbiota Liver-gut axis

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Modulating effects of acyl-coa synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity

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World Journal of Gastroenterology 2014年第40期20卷 14855-14864页

作者： Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke Kaemmerer Institute of Pathology RWTH Aachen University 52074 Aachen Germany Department of Chemical Biology Max Planck Institute of Molecular Physiology 44227 Dortmund Germany Department of Biochemistry and Molecular Cell Biology RWTH Aachen University 52074 Aachen Germany Department of Pediatrics RWTH Aachen University 52074 Aachen Germany

AIM: To investigate the role of acyl-coa synthetase 5 (ACSL5) activity in Wnt signaling in intestinal surface epithelia.

关键词： acyl-coa synthetases Wnt signaling Palmitoylation Intestinal barrier Carcinogenesis

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