检索结果-南通市图书馆

Simultaneous detection of enterovirus-D68 and vaccine-related poliovirus 3 in the stool samples of a 5-month hospitalized child with acute respiratory disease:A case report

在线全文

学校读者我要写书评

暂无评论

生物安全与健康(英文) 2023年第4期5卷 250-253页

作者： Wenzhe Su Qing Zeng Jinmei Geng Jingwen Liu Huaping Xie Kuibiao Li Pengzhe Qin Chaojun Xie Biao Di Guangzhou Center for disease Control and Prevention Guangzhou 510000China Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou 510000China Huadu Center for disease Control and Prevention Guangzhou 510803China

Human enterovirus(EV)infections can lead to various manifestations,with variable correlations between genotypes and *** enterovirus D68(EV-D68)was considered to be associated with acute respiratory disease and acute flaccid *** this short report,both EV-D68 and poliovirus 3 were detected in the stool of a hospitalized 5-month child who presented with acute respiratory symptoms and who was recently vaccinated with oral polio vaccine(OPV),using a metatranscriptomic high-throughput sequencing *** nearly full-length genome sequences with complete open reading frames of EV-D68 and poliovirus 3 were *** previously-reported neurovirulence-related amino acid substitution(T860N)in the EV-D68 VP1 region was observed,but the patient showed no neurological *** attention should be paid to EV-D68,and continuous multiple syndrome-based surveillance on non-polio enterovirus is called for.

关键词： Enterovirus EV-D68 Poliovirus 3 acute respiratory disease Whole genome sequencing Co-infection

Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses:a retrospective study

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第5期38卷 735-740页

作者： Xingui Tian Xiao Li Shuyan Qiu Rong Zhou Wenkuan Liu State Key Laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510182China

Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised ***,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent *** this study,the liver function test(LFT)results were retrospectively analyzed among children hospitalized(ageacute respiratory infection caused by *** transaminase(ALT)and aspartate aminotransferase(AST)levels were elevated in 7.74%and 46.89%of patients,*** patients with>2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or *** higher levels of ALT,AST,γ-glutamyl transpeptidase(γ-GT),and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection ***-55 infection led to significantly higherγ-GT,total bilirubin,and direct bilirubin levels than the other infection *** records of four patients with serial monitoring of the LFT results were further *** indicators remained abnormal during the entire hospitalization in these *** results indicate that HAdV infection is often accompanied by abnormal liver function,and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.

关键词： acute respiratory disease Adenovirus Hepatitis Liver enzyme Liver function test

Seroprevalence of Neutralizing Antibodies against Six Human Adenovirus Types Indicates the Low Level of Herd Immunity in Young Children from Guangzhou, China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2021年第3期36卷 373-381页

作者： Xingui Tian Ye Fan Changbing Wang Zhenwei Liu Wenkuan Liu Yun Xu Chuncong Mo Aiping You Xiao Li Xia Rong Rong Zhou State Key Laboratory of respiratory disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510182China Central Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510180China Institute of Clinical Blood Transfusion Guangzhou Blood CenterGuangzhou 510095China

Human adenoviruses(HAdVs) commonly cause many diseases such as respiratory diseases, gastroenteritis, cystitis worldwide. HAdV-3,-7,-4 and emergent HAdV-55 and HAdV-14 are the most important types causing severe respiratory diseases. There is no effective drug available for clinical treatment, and no vaccine available for the general ***, it is important to investigate the seroprevalence against HAdV for developing novel vaccines and vectors. In this study, we investigated the seroprevalence and titer levels of neutralizing antibodies(NAb) against HAdV-3,-4,-7,-14,-55,and-11 in total 278 healthy populations between 0 months and 49 years of age(228 children and 50 adults) from Guangzhou. In children under the age of 18 years, the seropositive rates were significantly increased against HAdV-3 at12.07%, 33.96%, and 64.29% and against HAdV-7 at 0%, 18.87%, and 19.05% in age groups of 1–2, 3–5, and 6–17 years,respectively. The seroprevalence was very low(0% - 8.1%) for all other four types. In adults aged between 18 and49 years, HAdV-3,-4, and-7(> 50.00%) were the most common types, followed by HAdV-14(38.00%),-55(34.00%),and-11(24.00%). Adults tended to have high NAb titers against HAdV-4 and-55. HAdV-55-seropositive donors tended to be HAdV-11-and HAdV-14-seropositive. These results indicated the low level of herd immunity against all six HAdV types in young children, and HAdV-14,-55,-11 in adults from Guangzhou City. Our findings demonstrate the importance of monitoring HAdV types and developing vaccines against HAdV for children and adults.

关键词： Human adenovirus(HAdV) Seroprevalence Neutralizing antibodies(NAb) Vaccination Vector acute respiratory disease

Molecular targets for COVID-19 drug development:Enlightening Nigerians about the pandemic and future treatment

在线全文

学校读者我要写书评

暂无评论

Biosafety and Health 2020年第4期2卷 210-216页

作者： Yusuf Muhammed Department of Biochemistry Federal University GusauAlong Zaria-Sokoto RoadPMB1001 GusauZamfara StateNigeria

There is little or no research initiated on enlightening Nigerians about the pathogenesis,targets for drug development and repositioning for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** disease 2019(COVID-19)is a viral infection causing symptoms like dry cough,sore throat,nasal congestion,tiredness,fever,loss of taste,and smell *** disease was first reported in Wuhan,China,in December *** infection is caused by SARS-CoV-2,which is the third introduction of a highly pathogenic coronavirus into the human *** are viruses with a positive RNA envelope assigned toα,β,γ,andδ***,SARS-CoV-2 belongs to theβ*** four structural proteins ofβcoronavirus are membrane(M),envelope(E),spike(S),and nucleocapsid(N)protein,mediation of coronavirus host infection is established by spike(S)***,the search for drug development targets and repositioning of existing therapeutics is essential for fighting the present *** was reviewed that therapeutics targeting SARS-CoV-2 binding to ACE2 receptor,viral RNA synthesis and replication,3CLpro,RdRp,and helicase will play a crucial role in the development of treatment for SARS-CoV-2 ***,the RdRp and spike protein of SARS-CoV-2 are the most promising targets for drug development and repositioning and vaccine *** combination with chloroquine/hydroxychloroquine are promising drug repositioning for the treatment of COVID-19,and mRNA-1273 targeting spike protein is the promising ***,as patient management and drug repositioning are taking place,it is imperative to identify other promising targets used by SARS-CoV-2 to establish infection,to develop novel therapeutics.

关键词： SARS-CoV-2 COVID-19 Molecular pathogenesis acute respiratory disease Drug development targets