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Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway

Journal of Animal Science and Biotechnology 2023年第4期14卷 1418-1437页

作者： Yuanyuan Wei Chen Gao Huiru Wang Yannan Zhang Jinhua Gu Xiuying Zhang Xuhao Gong Zhihui Hao Innovation Centre of Chinese veterinary medicine College of Veterinary MedicineChina Agricultural UniversityNo.2 Yuanmingyuan West RoadBeijing 100193China Key Biology Laboratory of Chinese Veterinary Medicine Ministry of Agriculture and Rural AffairsBeijing 100193P.R.China National Center of Technology Innovation for Medicinal function of Food National Food and Strategic Reserves AdministrationBeijingChina China Institute of Veterinary Drug Control Beijing 100081China

Background liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective *** fructus aqueous extracts(MFAEs)have served as successful treatments for many types of liver injury including fibrosis although the molecular mechanisms are unknown at *** To investigate the effect of MFAEs in alleviating acute and chronic liver injury and tried to decipher the underlying *** and results Mice were divided into 5 groups(n ps:contro=8)for acute(groups:control,0.3%CCl_(4),bifendate(BD),100 and 200 mg/kg MFAEs,7 d)and chronic(groul,10%CCl_(4),BD,100 and 200 mg/kg MFAEs,4 weeks)liver injury *** mouse was injected intraperitoneally with 10μL/g corn oil containing CCl_(4)expect the control ***2 cells were used in vitro *** communal components were identified by *** utilized a mouse model for acute and chronic liver injury using CCl_(4)and MFAEs administration effectively blocked fibrosis and significantly inhibited inflammation in the *** activated the nuclear factor erythroid derived 2 like 2/heme oxygenase 1(Nrf2/HO-1)pathway and promoted the synthesis of the antioxidants glutathione(GSH),superoxidedismutase(SOD)and glutathione peroxidase(GSH-Px)that resulted in reduced levels of CCl_(4)-induced oxidative stress molecules including reactive oxygen *** extracts administered to mice also inhibited ferroptosis in the liver by regulating the expression of Acyl-CoA synthetase long chain family member 4(ACSL4),solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),thus reducing the occurrence of liver *** in vivo and in vitro tests indicated that the mechanism of MFAEs protection against liver fibrosis was linked to activation of Nrf2 *** effects were blocked in vitro by the addition of a specific Nrf2 *** MFAEs inhibited oxidative stress,ferroptosis and inflammation o

关键词： acute and chronic liver injury Ferroptosis Mori fructus aqueous extracts Nrf2 Oxidative stress

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