检索结果-南通市图书馆

Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第7期15卷 1266-1273页

作者： Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan Department of Neurology Peking University Third HospitalBeijingChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Department of Neurology Huang Gang Central HospitalHuanggangHubei ProvinceChina Department of Neurology The First People's Hospital of Luoyang CityLuoyangHenan ProvinceChina Department of Neurology General Hospital of Xuzhou Mining GroupXuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Jining Medical UniversityJiningShandong ProvinceChina Department of Neurology People's Hospital of Yichun CityYichunJiangxi ProvinceChina Department of Neurology The First Hospital of Shijiazhuang CityShijiazhuangHebei ProvinceChina Department of Neurology Jining No.1 People's HospitalJiningShandong ProvinceChina Department of Neurology Baotou Central HospitalBaotouInner Mongolia Autonomous RegionChina Department of Neurology Jiangxi Provincial People's HospitalAffiliated People's Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurology The Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Neurology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve ***,there is still a need for high-level clinical evidence from large samples to support the use of *** therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May *** patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)*** patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA *** on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 *** to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate *** on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after *** the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel *** analysis revealed that CEGI led to more significant improvements in moderate stroke *** drug-related adverse events occurred in the CEGI or

关键词： acute cerebral infarction Barthel Index cattle encephalon glycoside and ignotin modified Rankin Scale National Institutes of Health Stroke Scale neuroprotectants recovery rate stroke

Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第31期8卷 2895-2903页

作者： Sijie Li Yanbo Zhang Guo Shao Mingfeng Yang Jingzhong Niu Guowei Lv Xunming Ji Institute of Hypoxic Medicine Xuanwu Hospital Capital Medical University Department of Neurology Affiliated Hospital of Taishan Medical University Research Center of Biology and Medicine Baotou Medical College

Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we in- duced a photochemical model of cerebral infarction in an inbred line of mice （BALB/c）. Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment. Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction, mainly in neurons and vascular endothelial cells. Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31. Moreover, hypoxic preconditioning reduced the infarct volume and improved neu- rological function in mice. These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra, which promoted angiogenesis.

关键词： neural regeneration brain injury hypoxic preconditioning acute cerebral infarction ischemicpenumbra vascular endothelial growth factor CD31 angiogenesis neuroprotection grants-supported paper neuroregeneration

Plasma level of neuron specific enolase in patients with acute cerebral infarction:A case-control study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2009年第1期4卷 62-66页

作者： Guoping Tian Yang Zhang Weiping Cheng Department of Neurology Shenyang First People's Hospital (i. e. Shenyang Brain Hospital) Shengyang 110041 Liaoning Province China Department of Neurology First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine Harbin 150040 Heilongjiang Province China

BACKGROUND： The plasma level of neuron specific enolase （NSE） can be used to diagnose and evaluate neuronal injury and predict early prognosis. OBJECTIVE： To observe the dynamic changes in plasma levels of NSE in patients with acute cerebral infarction, and to investigate its correlations with disease severity and prognosis. DESIGN, TIME AND SETTING： This non-randomized, concurrent case-control experiment was performed at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007. PARTICIPANTS： Eighteen patients with acute cerebral infarction, who received treatment at the Department of Neurology, First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine between May and July 2007, were recruited into the patient group. An additional 10 healthy individuals, who received health examinations simultaneously, were included as controls. METHODS： Following admission （within 3 days） and at days 6, 12, and 30 subsequent to acute cerebral infarction attack, 3 mL venous blood was taken from each patient before the morning meal to determine the plasma level of NSE by enzyme-labeled immunosorbent assay. One-time blood extraction was performed in each healthy subject during the health examination for the same purpose as in patients. At 6 and 30 days following acute cerebral infarction attack, CT examination was performed for calculation of cerebral infarction volume according to the Tada formula. Following admission and at 30 days of disease invasion, all patients were scored by the National Institutes of Health Stroke Scale （NIHSS, 13 items）. MAIN OUTCOME MEASURES： Comparison of NSE plasma level between acute cerebral infarction patients and healthy individuals; correlations of NSE plasma level in acute cerebral infarction patients with cerebral infarction volume, NIHSS score, and prognosis. RESULTS： Following admission and at days 6 and 12 of disease invasion, t

关键词： neuron specific enolase acute cerebral infarction prognosis functional neurological deficit

Effects of acupuncture therapy on plasma neuropeptide Y levels and resuscitation in patients with very early stage acute cerebral infarction A randomized controlled study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2009年第2期4卷 157-160页

作者： Guozhong Zhang Lina Ning Sujuan Gao Department of Rehabifitation of Traditional Chinese Medicine Affiliated Hospital of Medical College of Chinese People's Armed Police ForceTianjin 300162 China

BACKGROUND： It is known that acupuncture therapy can decrease plasma neuropeptide Y （NPY） levels in patients with cerebral infarction, but different types of acupuncture therapy used in various stages of cerebral infarction have not been evaluated. OBJECTIVE： To explore the effect of acupuncture therapy on resuscitation （Xingnao Kaiqiao） and plasma NPY levels in patients with very early stage acute cerebral infarction. DESIGN, TIME AND SETTING： This case-controlled study was performed at the Affiliated Hospital of the Medical College of the Chinese People＇s Armed Police Force between September 2004 and October 2005. PARTICIPANTS： Sixty patients with acute cerebral infarction of ≤ 6 hours were used in this study. Patients were randomly divided into an acupuncture therapy group （n = 30） and a routine treatment group （n = 30）. Another 30 healthy subjects were used as the control group. METHODS： The acupuncture therapy of Xingnao Kaiqiao used in the acupuncture therapy group was based on routine western medical treatment and was performed at bilateral Neiguan （PCG） using the twirling, reinforcing-reducing method, Renzhong （DU26） using heavy bird-pecking needling, Sanyinjiao （SPG） using reinforcing and reducing by lifting and thrusting the needle, Jiquan （HT1）, Weizhong （BL40） and Chize （LU5） using reinforcing and reducing by lifting and thrusting the needle. The acupuncture lasted for 14 days. Patients in the routine treatment group underwent routine medical treatment and no intervention was given to subjects in the control group. MAIN OUTCOME MEASURES： A 4 mL venous blood sample was obtained at different time points, i.e., immediately after hospitalization, the next morning, 7 and 14 days after treatment, to measure plasma NPY levels pre- and post-treatment using the radio-immunity method. RESULTS： The plasma NPY levels were significantly higher in both the routine treatment group and the acupuncture therapy group than in the control group pre- and post-tre

关键词： acupuncture acute cerebral infarction very early stage neuropeptide Y

Differential expression of 114 oxidative stress-related genes in peripheral blood mononuclear cells of acute cerebral infarction patients A gene microarray experiment

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2010年第15期5卷 1185-1189页

作者： Jing Yang Fei Zhong Mingshan Ren Jiangming Zhao Department of Neurology Anhui Provincial Hospital Hefei 230022 Anhui Province China Department of Oncology First Affiliated Hospital of Anhui Medical University Hefei 230036 Anhui Province China

Previous studies have focused on the analysis of single or several function-related genes in oxidative stress; however, little information is available regarding altered expression of oxidative stress-related genes in the process of ischemia-reperfusion injury from microarray experiments. The aim of the present study was to investigate the changes in cell oxidative stress- and toxicity-related gene expression utilizing microarray screening in patients with acute cerebral infarction during cerebral ischemia-reperfusion injury. Of the included 114 genes, expression was significantly upregulated in eight genes, including three heat shock protein-related genes, one oxidative and metabolic stress-related gene, one cell growth arrest/senescence related gene, two apoptosis signal-related genes, and one DNA damage and repair related gene. Expression was significantly downregulated in four genes, including one cell proliferation/cancer related gene, two oxidative and metabolic stress-related genes and one DNA damage and repair related gene. The results demonstrated that cerebral ischemia-reperfusion injury in patients with acute cerebral infarction was affected by many genes including oxidative stress-, heat shock-, DNA damage and repair-, and apoptosis signal-related genes. Therefore, it could be suggested that cerebral ischemia-reperfusion injury may be subjected to complex genetic regulation mechanisms.

关键词： acute cerebral infarction cerebral ischemia and reperfusion oxidative stress microarray brain injury neural regeneration

Analysis of mental health status and related factors in patients with acute cerebral infarction

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2023年第10期13卷 793-802页

作者： Qing-Qin Chen Fu-Mei Lin Dan-Hong Chen Yi-Min Ye Guo-Mei Gong Fen-Fei Chen Su-Fen Huang Shan-Ling Peng Quanzhou Medical College Quanzhou 362000Fujian ProvinceChina Department of Emergency Fuqing City Hospital Affiliated to Fujian Medical UniversityFuqing 350300Fujian ProvinceChina Department of Neurology Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina Department of Nursing The 900 Hospital of the Joint Service Support Force of the People’s Liberation Army of ChinaFuzhou 350025Fujian ProvinceChina

BACKGROUND acute cerebral infarction(ACI)is characterized by a high incidence of morbidity,disability,recurrence,death and heavy economic burden,and has become a disease of concern in global *** ACI has serious effects on patients’physical status,life and economy,often causing anxiety,depression and other psychological problems,these problems can lead to the aggravation of physical symptoms;thus,it is very important to understand the factors affecting the mental health of these *** To understand the elements that affect the mental health of patients who have suffered an *** A questionnaire survey was conducted among patients with ACI admitted to three tertiary hospitals(Quanzhou First Hospital,Fuqing City Hospital Affiliated to Fujian Medical University,and the 900 Hospital of the Joint Service Support Force of the People’s Liberation Army of China)in Fujian Province from January 2022 to December 2022 using the convenience sampling *** inpatients who met the inclusion criteria were *** consent was obtained from the patients before the investigation,and a face-to-face questionnaire survey was conducted using a unified *** questionnaire included a general situation questionnaire,Zung’s self-rating depression scale and Zung’s self-rating anxiety *** questionnaires were checked by two researchers and then the data were input and sorted using Excel *** general situation of patients with ACI was analyzed by descriptive statistics,the influence of variables on mental health by the independent sample t test and variance analysis,and the influencing factors on psychological distress were analyzed by multiple stepwise *** The average age of the 220 patients with ACI was 68.64±10.74 years,including 142 males and 78 *** of the patients were between 60 and 74 years old,the majority had high school or technical secondary school education,most lived with their spouse,and most lived in cit

关键词： acute cerebral infarction Mental health Self-rating depression scale Self-rating anxiety scale Influencing factor Correlation analysis

Classification of Oxfordshire community stroke project assisted by transcranial Doppler ultrasound examination for treating acute cerebral infarction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2006年第5期1卷 441-444页

作者： Xiaohua Xiao Jie Situ Tinghui Li Shaohong Qiu Department of Internal Medicine Shenzhen Hospital of Prevention and Treatment for Occupational Disease （original Shenzhen Railway Hospital） Shenzhen 518001 Guangdong Province China

BACKGROUND： The early correct diagnosis of acute cerebral infarction （ACI） is very important for choosing therapeutic regimen. The classification of Oxfordshire community stroke project （OCSP） provides guide for easy and rapid diagnosis and choosing therapeutic regimen in clinical practice. But current operation is not satisfied. Only depending on clinical symptoms and body signs do objective evidences lack. Transcranial Doppler ultrasound （TCD） examination may provide hemodynamical evidences for the correct classification of OCSP to some extent. OBJECTIVE： To compare the results of OCSP classification and TCD examination for treating ACI in patients and analyze the relationship between them as well as the effect of TCD on the correct classification of OCSP. DESIGN ： Controlled observation.SETTING： Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupationa Disease. PARTICIPANTS： Thirty-eight inpatients with ACI including 21 males and 17 females, aged 50 to 81 years, who received treatment in the Department of Internal Medicine, Shenzhen Hospital of Prevention and Treatment for Occupational Disease within 24 hours after onset from October 2002 to October 2005 were involved. The involved inpatients all confirmed to the diagnostic criteria of ACI formulated in the 4^th National Cerebrovascular Diseases Conference. All the cases received skull computer tomography （CT） or magnetic resonance imaging （MRI） examinations at 24 hours after onset. Those patients who had no obvious infarct focus in skull CT examination within 24 hours after onset were performed re-examination to verify ACI within 72 hours after onset. Informed consents of examination method were obtained from all the patients. METHODS ： According to the classification of OCSP, the patients were assigned into 4 subtypes： lacunar infarction （LACI）, total anterior circulation infarction （TACI）, part anterior circulation infarction （PACI） and posterior circulation infar

关键词： acute cerebral infarction ultrasound examination blood flow velocity of Prevention and Treatment middle cerebral artery sequence of transcranial Doppler Occupational Disease magnetic resonance imaging diagnostic criteria computer tomography Doppler ultrasound current operation clinical practice reference value examination of diagnosis of

Value of Tongue Color Combined with Sublingual Microcirculation in Predicting the Severity of Mild to Moderate acute cerebral infarction

在线全文

学校读者我要写书评

暂无评论

World Journal of Integrated Traditional and Western Medicine 2023年第4期9卷 31-35页

作者：赵帅张勇高伟李静波姜婧张鹏翎 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine Nanjing 210028China Jiangsu Provincial Academy of Traditional Chinese Medicine Nanjing 210028China Geriatric Hospital of Nanjing Medical University Nanjing 210028China

Objective:To explore the value of tongue color combined with sublingual microcirculation in predicting the severity of mild to moderate acute cerebral infarction(ACI).Methods:From January to December 2022,90 patients with ACI were admitted to the Department of Neurology of Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western *** to the NHISS score on the 5th day of admission,the patients were divided into mild group(35 cases)and moderate group(55 cases).The changes of tongue color and arterial lactate on the 5th day of admission were observed and ***-stream dark field imaging(SDF)was used to determine the total vascular density(TVD),perfused vascular density(PVD),perfused vascular ratio(PPV)and microvascular flow index(MFI).The multivariate logistic regression analysis was used to screen the risk factors for the severity of ACI,and the receiver operating characteristic curve(ROC)to evaluate their values in predicting ACI ***:There was no significant difference in lactate between the two groups(P>0.05),and the frequency of red tongue in the mild group was higher,and the frequency of red tongue in the moderate group was significantly higher in the dark tongue group(P<0.05).The multivariate logistic regression analysis showed that PVD and PPV were independent risk factors for the severity of mild to moderate ACI(P<0.05).The ROC curve analysis showed that an area under the curve of 0.832 was achieved by the combination of PVD and PPV,which was larger than that of a single ***:Tongue color combined with sublingual microcirculation can be combined to predict the severity of mild to moderate ACI.

关键词： acute cerebral infarction Tongue color Sublingual microcirculation Sidestream dark vision Value analysis

A Case of acute Upper Gastrointestinal Bleeding in Liver Cirrhosis Complicated by acute cerebral infarction and acute Myelitis

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2023年第5期11卷 303-309页

作者： Xiaohui Liao Tengteng Xu Xianhua Zhang Xianliang Mi Changqing Yang Zibai Wei Department of Gastroenterology Heping Hospital Affiliated to Changzhi Medical College Changzhi China

Background: acute upper gastrointestinal bleeding in liver cirrhosis combined with acute cerebral infarction is uncommon in clinical work, and then combined with acute myelitis is even rarer and more complex, which poses a greater challenge to clinical diagnosis and treatment. This paper reports a case of acute upper gastrointestinal bleeding in liver cirrhosis complicated by acute cerebral infarction and acute myelitis, which be hoped to provide a reference for clinical work. Methods: We retrospectively evaluated the clinical information of a 68-year-old female admitted to the Digestive Medical Department with acute gastrointestinal bleeding and appeared limb movement disorder on the third day. Results: The patient was eventually diagnosed with acute upper gastrointestinal bleeding in liver cirrhosis complicated by acute cerebral infarction and acute myelitis. Conclusions: When patients with liver cirrhosis have abnormal neurological symptoms, in addition to liver cirrhosis-related complications, doctors need to consider cerebrovascular diseases and myelitis.

关键词： Liver Cirrhosis Upper Gastrointestinal Bleeding acute cerebral infarction acute Myelitis