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Mechanism of acupuncture and moxibustion on Promoting Mucosal Healing in Ulcerative Colitis

Chinese Journal of Integrative Medicine 2023年第9期29卷 847-856页

作者： LI Han YE Xiao-feng SU Yang-shuai HE Wei ZHANG Jian-bin ZHANG Qi ZHAN Li-bin JING Xiang-hong Department of acupuncture and moxibustion Changzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213002China Nanjing University of Chinese Medicine Nanjing210023China Research Center of Meridians Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing100700China Department of acupuncture and moxibustion the Second Affiliated Hospital of Nanjing University of Chinese MedicineNanjing211005China Liaoning University of Chinese Medicine Shenyang116600China

The latest guideline about ulcerative colitis(UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall(mechanical barrier) injury with the imbalance between intestinal epithelial cells(IECs) regeneration and death, as well as tight junction(TJ) dysfunction. It is suggested that biological barrier(gut microbiota), chemical barrier(mucus protein layer, MUC) and immune barrier(immune cells) all take part in the imbalance, leading to mechanical barrier injury. Lots of experimental studies reported that acupuncture and moxibustion on UC recovery by adjusting the gut microbiota, MUC and immune cells on multiple targets and pathways, which contributes to the balance of IEC regeneration and death, as well as TJ structure recovery in animals. Moreover, the validity and superiority of acupuncture and moxibustion were also demonstrated in clinic. This paper aims to review the achievements of acupuncture and moxibustion on mucosal healing and analyse the underlying mechanisms.

关键词： acupuncture and moxibustion ulcerative colitis mucosal healing intestinal epithelial cells regeneration and death tight junction function gut microbiota review

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acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats

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Neural Regeneration Research 2014年第9期9卷 968-972页

作者： Hua Zhou Guojie Sun Lihong Kong Yanjun Du Feng Shen Shuju Wang Bangguo Chen Xiaoling Zeng Hubei University of Chinese Medicine

To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer’s disease, we established a rat model of Alzheimer’s disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui（GV20） and Shenshu（BL23）. Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer’s disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.

关键词： nerve regeneration brain injury acupuncture and moxibustion pretreatment Alzheimer’s disease axin β-catenin NSFC grant neural regeneration

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acupuncture and moxibustion for functional hypothalamic amenorrhea by establishing artificial cycle:a controlled trial

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World Journal of acupuncture-moxibustion 2016年第1期26卷 7-13页

作者：许素瑜李艳吴菲远卓晓云湛江中心人民医院中医部

Objective To observe the clinical efficacy of acupuncture and moxibustion in treatment of functional amenorrhea by establishing artificial *** One hundred and twelve eligible patients with functional amenorrhea were divided into an acupuncture-moxibustion group（64 cases） and a western medication group（48 cases） by adopting random *** to the pattern differentiation of amenorrhea of traditional Chinese medicine,the patients in the acupuncture-moxibustion group were classified into two types：amenorrhea due to blood depletion and amenorrhea due to stagnation of *** patients with amenorrhea due to blood depletion,Guanyuan（关元 CV4）,Zhongji（中极CV 3）,GuiTlai（归来ST 29）,Geshu（膈俞 BL 17）,Ganshu（肝俞BL 18）,Pishu（脾俞 BL 20） and Shenshu（肾俞 BL 23） were *** first,BL 17,BL 18,BL 20 and BL 23 were needled;after deqi,reinforcing method was applied,and the needles were not ***,warmingneedle moxibustion was applied at CV 4,CV 3 and ST 29,and the needles were retained for 30 *** patients with amenorrhea due to stagnation of blood,CV 3,Qihai（气海CV 6）,Xuehai（血海 SP 10）,Sanyinjiao（三阴交 SP 6）and Xingjian（行间 LR 2） were selected,reducing method was applied,and the needles were retained for 30 *** treatment was performed once a day,and treatment for 15 consecutive days were the 1st *** 2nd and3 rd cycles started from the 5th day of menstruation（for the patients still not menstruating,the 2nd and 3rd cycles started from the 29 th and 57 th days since the 1st day of treatment）,and the treatment lasted for 15 *** cycles were *** the western medicine group,estrogen-progestogen was taken orally for 21 days（one cycle） to establish a artificial *** levels of FSH and LH were tested and compared on the 3rd day of menstruation before treatment and after the 3rd cycle of treatment,and the adverse effects were analyzed ***-up visit was conducted for the patients after treatment for three cycles,and the recurrence rate was

关键词： functional amenorrhea acupuncture and moxibustion artificial cycle controlled trial

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China Association of acupuncture–moxibustion Evidence-based clinical practice guideline of acupuncture and moxibustion: Primary dysmenorrhea

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World Journal of acupuncture-moxibustion 2019年第4期29卷 294-300页

作者： Ji-ping Zhao Bi-ling Wen Jun Wang Xiao-dong Wu Ming-jie Zi Peng Wang Peng Bai Sheng-nan Guo Sheng Chen 机构不详

Dysmenorrhea refers to periodic abdominal pain,or radiating to lumbosacral *** the severe case,it is intolerable,combined with nausea and vomiting *** disease is commonly seen in unmarried young *** studies have shown that dysmenorrhea is the most common gynecological disease,especially in young women[1].acupuncture and moxibustion have a long history in the treatm ent of primary dysmenorrhea(hereinafter referred to as PD),and compared with medication,the advantages are presented in the *** by the Standardization Working Committee of China Association for acupuncture and moxibustion(CAAM),Department of acupuncture and moxibustion,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine has undertaken the drafting of Evidence-Based Clinical Practice Guideline of acupuncture and moxibustion:Primary Dysmenorrhea(hereinafter referred to as the Guideline).The Guideline was issued in 2014 by *** summarizes the research achievements in acupuncture-moxibustion treatm ent for dysmenorrhea in recent decades and is intended to standardize the clinical regimen of treatm ent with acupuncture and moxibustion so as to improve the clinical effect.

关键词： Evidence based medicine Clinical practice Guideline acupuncture and moxibustion Primary dysmenorrhea

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acupuncture and moxibustion (Part Ⅱ)

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China Today 2011年第9期60卷 66-67页

The therapeutic approaches of acupuncture and moxibustion acupuncture and moxibustion are unique treatments and *** therapies regulate internal functions through outside *** can cure disease by stimulating acupoints a... 详细信息

关键词： acupuncture and moxibustion

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acupuncture and moxibustion (Part Ⅰ)

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China Today 2011年第8期60卷 76-77页

In the Neolithic Age more than 8,000 years ago,the forefathers of the Chinese began to use stone needles to treat *** is how acupuncture originated.

关键词： Emperor acupuncture and moxibustion Figure

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acupuncture and moxibustion (Part Ⅲ)

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China Today 2011年第10期60卷 70-71页

moxibustion therepy moxibustion therapy refers to the use of burning mugwort to warm up certain parts of the human body and stimulate circulation through acupoints and meridians so as to prevent and cure disease.

关键词： Part III acupuncture and moxibustion

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acupuncture and moxibustion treating lower urinary tract symptoms due to benign prostatic hyperplasia:a systematic review and network meta-analysis

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acupuncture and Herbal Medicine 2022年第2期2卷 84-90页

作者： Zhe Chen Tao Jiang Yingying Peng Xiaoyu Qiang Fengwen Yang Haiyin Hu Chunxiang Liu Myeong Soo Lee Evidence-based Medicine Center Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of acupuncture and moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina National Clinical Research Center for Chinese Medicine acupuncture and moxibustion TianjinChina Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Korea

Objective: Lower urinary tract symptoms(LUTS) caused by benign prostatic hyperplasia(BPH) affect the quality of life of elderly individuals. acupuncture and moxibustion are used in the clinic in China for improving LUTS symptoms due to BPH. However,there is no evidence to suggest which is the best option. We compared the efficacy of acupuncture and moxibustion to provide evidence for clinical ***: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan Fang Data, and VIP databases were searched from inception to July 2020 to identify the randomized controlled trials(RCTs) of acupuncture and moxibustion for LUTS due to BPH. Two researchers filtered studies and extracted the information independently. This study conducted a network meta-analysis using the Bayesian random method. The interventions ranking was evaluated using the surface under the cumulative ranking curve(SUCRA).Results: We finally included 40 studies comprising 10 treating therapies and 3,655 patients with LUTS caused by BPH. In terms of the International Prostate Symptom Score, maximum urinary flow rate, and quality of life, electroacupuncture(EA) [MD =-3.6,95% credible interval(CrI)(-5.5,-1.8), very low certainty of evidence;MD = 2.2, 95% CrI(1.1, 3.3), low certainty of evidence;MD =-1.3, 95% CrI(-2.2,-0.43), very low certainty of the evidence] may be consistently the optimal treatment compared with other interventions, with SUCRA values of 84%, 81%, and 89%, ***: Of all treatments, EA may have the best efficacy with fewer adverse events for LUTS due to BPH. The quality of evidence supporting this result is low to very low certainty of the evidence due to the limitations of primary studies;thus, more highquality RCTs are needed for further evidence.

关键词： acupuncture and moxibustion Benign prostatic hyperplasia Lower urinary tract symptoms Network meta-analysis Randomized controlled trial

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International Communication of acupuncture and moxibustion Popular in the West

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Chinese Medicine and Culture 2024年第2期7卷 119-127页

作者： QIAO Huijun LIU Jingyuan HU Weiguo YANG Yuyang Secretariat of World Federation of acupuncture-moxibustion Societies Beijing 100061China China Academy of Chinese Medical Sciences Beijing 100700China Department of acupuncture and moxibustion Swiss University of Traditional Chinese MedicineBad Zurzach 5330Switzerland

With the development of traditional Chinese medicine(TCM)acupuncture and moxibustion,research on acupuncture and moxibustion in the Western world is *** concept of acupuncture and moxibustion popular in the West is *** investigating the localization of acupuncture and moxibustion in the Western world,this paper introduces several kinds of acupuncture and moxibustion popular in the West and concludes the spread of acupuncture and moxibustion popular in the West through hospitals and clinics,academic works,social organizations,education,and *** paper provides a global vision developing domestic acupuncture and moxibustion and promoting academic prosperity and technical progress of world acupuncture and moxibustion system.

关键词： acupuncture and moxibustion International communication Western world

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Efficacy of acupuncture and moxibustion in treating Bell’s palsy: a multicenter randomized controlled trial in China

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Chinese Medical Journal 2004年第10期117卷 1502-1506页

作者：李瑛梁繁荣余曙光李常度胡玲香周东袁秀丽李怡夏晓红 acupuncture and Tuina College Chengdu University of TCM Chengdu 610075 China First Affiliated Hospital of Chengdu University of TCM Chengdu 610075 China West China Hospital Sichuan University Chengdu 610042 China TCM Hospital of Mianyang City Mianyang 621000 China People’s Hospital of Sichuan Province Chengdu 610075 China

Background Bell’s palsy involves acute facial paralysis due to inflammation of the facial nerve. acupuncture and moxibustion (acu-moxi) is beneficial in treating facial palsy. In order to verify the efficacy of acu-moxi on Bell’s palsy, a randomized single-blind, multicenter clinical trial was *** A total of 480 patients from four clinical centers were involved in this trial, of whom 439 completed the trial and 41 did not. All patients were randomly assigned to either the control group or to one of two treatment groups. The control group was treated with prednisone, vitamin B_1, vitamin B_ 12, and dibazole; the treatment groups were treated either with acu-moxi alone or in combination with prednisone, Vitamin B_1, vitamin B_ 12, and dibazole. Symptoms and signs, the House-Brackmann scale, and facial disability index (FDI) scores were assessed and determined both pre- and post-treatment to evaluate the effectiveness of the treatment *** The characteristics of the control and two treatment groups were comparable without statistically significant differences before treatment. There were significant differences between the control and treatment groups after treatment (χ2=15.265, P=0.018). According to evaluations based on the House-Brackmann scale and FDI scores, the effectiveness of treatment in the two treatment groups was better than in the control group and was most effective in patients receiving acu-moxi treatment alone (Z=-2.827, P=0.005). Conclusion The efficacy of acu-moxi treatment for Bell’s palsy is verified scientifically.

关键词： acupuncture and moxibustion Bell’s palsy multicenter trial randomized controlled trial House-Brackmann scale FDI score

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