检索结果-南通市图书馆

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Fa-Jun NAN~2,Jian-Feng LIU~1 1 Sino-France Laboratory for Drug Screening,Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,China 2 National Center for Drug Screening,State Key Laboratory of Drug Research,Shanghai Institute of MateriaMedica, Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai,China

Many GPCR agonists can activate receptor-tyrosine-kinases(RTKs) through transactivation,the mechanisms of which are poorly ***,we have investigated IGF-1 receptor(IGF-IR) transactivation by GABA receptor using a chemical biology approach in rat primary *** show that GABA receptor activation induces a dynamic assembly and disassembly of a protein complex,including both receptors and their downstream ***,a non-receptor tyrosine kinase,plays a key role in coordinating this dynamic ***,such a dynamic process is critical for transactivation and transactivation-dependent neuronal *** results reveal an important mechanism underlying GPCR transactivation of RTKs.

关键词： GABAB receptor IGF-IR transactivation FAK dynamic protein-protein interactions activity-based probe

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells

引用

Chinese Chemical Letters 2024年第2期35卷 451-454页

作者： Jiahao Zhang Haiyue Peng Zi'an Chen Guorui Li Jing Huang State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Animal Models and Molecular MedicineSchool of Biomedical SciencesHunan UniversityChangsha 410082China

Protein S-sulfenylation(protein sulfenic acid),as one of the most significant oxidative post-translational modifications(OxiPTMs),plays a vital role in regulating protein function.A variety of activity-based probes have been developed to profile sulfenic acid in living ***,due to the transient presence and low content of sulfenic acid in living cell,high doses of probes are needed to achieve efficient *** importantly,current probes have no temporal control over sulfenic acid *** overcome these limitations,two caged cysteine sulfenic acid probes DYn-2-ONB and DYn-2-Cou with either an o-nitrobenzyl or coumarin protecting group were developed in this *** probes can be efficiently uncaged via irradiation to produce the active C-nucleophile probe *** assay in living cells demonstrated DYn-2-ONB exhibited better labeling capacity compared with DYn-2,providing it as a powerful tool for improved monitoring of protein S-sulfenylation in living cells.

关键词： Cysteine Sulfenic acid activity-based probe Photocage Light activation Protein S-sulfenylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

activity-based Chemical probes:Development and Applications

Activity-based Chemical Probes:Development and Applications

引用

第八届全国化学生物学学术会议

作者： Qing Zhang Yiqing Zhou Tianlin Guo Zhengying Pan Shenzhen Key Laboratory of Chemical Genomics School of Chemical Biology and BiotechnologyShenzhen Graduate School

＜正＞activity-based chemical probes（ABPs）have gained significant interests in both chemical biology and drug discovery *** this type of small molecule probes,information on protein targets at the functional level,rather than the expression level,can be *** also provides a direct and elegant way to study relationships between targets and drug *** this presentation,we will

关键词： activity-based probe protease kinase

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：