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Exploration of the contributing factors to the walking and biking travel frequency using multi-level joint models with endogeneity

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Journal of Traffic and transportation Engineering(English Edition) 2022年第6期9卷 1044-1054页

作者： Mankirat Singh Wen Cheng Ranjithsudarshan Gopalakrishnan Yihua Li Menglu Cao Department of Civil Engineering California State Polytechnic UniversityPomonaCA 91768USA Department of Logistics Engineering Central South University of Forestry and TechnologyChangsha 410004China

The enormous advantages of active transportation lead the transportation research focus towards enhancing the walking and biking *** present study explored the influential factors to the walking and biking travel frequency based on data obtained from the National Household Travel Survey California add-on *** study features some ***,bivariate models were used to account for the common unobserved heterogeneity shared at both household and personal ***,endogeneity was explicitly ***,both variable importance ranking and correlation analysis are employed to determine the different features to be fed into each of the joint *** results illustrated that the models developed with endogeneity performed better than the models without *** influential variables which includes mode to work by bicycle,public transit usage,count of household members,and multiple race responses,tend to have statistically significant impacts on walking and biking trips.

关键词： active transportation Household and personal levels Bivariate models Endogeneity

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Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy

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Bioactive Materials 2021年第10期6卷 3473-3484页

作者： Xin Li Helin Li Changchang Zhang Andrij Pich Lingxi Xing Xiangyang Shi Department of Gynecology and Obstetrics XinHua Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai200092China DWI-Leibniz-Institute for Interactive Materials e.V. 52056AachenGermany College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Institute for Technical and Macromolecular Chemistry RWTH Aachen University52074AachenGermany CQM-Centro de Química da Madeira Universidade da MadeiraCampus da Penteada9000-390FunchalPortugal Aachen Maastricht Institute for Biobased Materials Maastricht University6167RD GeleenNetherlands

For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid ***,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs)for enhanced tumor delivery and augmented *** was first grafted with PPy to form CH-PPy polymers that were used to form CH-PPy NGs through glutaraldehyde cross-linking via a miniemulsion *** CH-PPy NGs could be finely treated with an alkaline solution to generate ultrafast charge-reversible CH-PPy-OH-4 NGs(R-NGs)with a negative charge at a physiological pH and a positive charge at a slightly acidic *** R-NGs display good cytocompatibility,excellent protein resistance,and high doxorubicin(DOX)loading ***,the prepared R-NGs/DOX have prolonged blood circulation time,enhanced tumor accumulation,penetration and tumor cell uptake due to their self-adaptive charge switching to be positively charged,and responsive drug delivery for augmented chemotherapy of ovarian carcinoma in ***,the tumor accumulation of R-NGs/DOX(around 4.7%)is much higher than the average tumor accumulation of other nanocarriers(less than 1%)reported *** developed self-adaptive PPy-grafted CH NGs represent one of the advanced designs of nanomedicine that could be used for augmented antitumor therapy with low side effects.

关键词： Ultrafast charge conversion Nanogels active transportation Deep tumor penetration Enhanced antitumor activity

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