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active chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses

引用

World Journal of Gastroenterology 2008年第34期14卷 5274-5281页

作者： Yan-Hui Ma Wei-Zhi Cheng Fang Gong An-Lun Ma Qi-Wen Yu Ji-Ying Zhang Chao-Ying Hu Xue-Hua Chen Dong-Qing Zhang Shanghai Jiao Tong University School of Medicine Shanghai Institute of Immunology Shanghai 200025 China Shanghai Institute of Digestive Surgery Ruijin Hospital Shanghai 200025 China Centre de recherche du CHUM Hopital Notre- Dame Universite de Montreal Montreal Quebec H2L 4M1 Canada

AIM:To investigate the potential role of active chinese mistletoe lectin-55 (ACML-55) in tumor immune surveillance. METHODS: In this study, an experimental model was established by hypodermic inoculating the colon cancer cell line CT26 (5 × 105 cells) into BALB/c mice. The experimental treatment was orally administered with ACML-55 or PBS, followed by the inoculation of colon cancer cell line CT26. Intracellular cytokine staining was used to detect IFN-γ production by tumor antigen specific CD8+ T cells. FACS analysis was employed to profi le composition and activation of CD4+, CD8+, γδ T and NK cells. RESULTS: Our results showed, compared to PBS treated mice, ACML-55 treatment signifi cantly delayed colon cancer development in colon cancer -bearingBalb/c mice in vivo. Treatment with ACML-55 enhanced both Ag specifi c activation and proliferation of CD4+ and CD8+ T cells, and increased the number of tumor Ag specific CD8+ T cells. It was more important to increase the frequency of tumor Ag specific IFN-γ producing-CD8+ T cells. Interestingly, ACML-55 treatment also showed increased cell number of NK, and γδT cells, indicating the role of ACML-55 in activation of innate lymphocytes. CONCLUSION: Our results demonstrate that ACML-55 therapy can enhance function in immune surveillance in colon cancer-bearing mice through regulating both innate and adaptive immune responses.

关键词： active chinese mistletoe lectin-55 Coloncancer Immune surveillance Tumor therapy Agspecific-CD8+ T cell

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