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actinidia chinensis polysaccharide interferes with the epithelial-mesenchymal transition of gastric cancer by regulating the nuclear transcription factor-κB pathway to inhibit invasion and metastasis

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Journal of Traditional Chinese Medicine 2024年第05期44卷 896-905页

作者： ZHANG Guangshun XU Xiaonan XU Chuyun LIAO Guanghui XU Hao LOU Zhaohuan ZHANG Guangji School of Pharmaceutical Sciences Zhejiang Chinese Medical University Key Labortary of Blood-stasis-toxin Syndrome of Zhejiang Province School of Basic Medical Sciences Zhejiang Chinese Medical University Traditional Chinese Medicine "Preventing Disease" Wisdom Health Project Research Center of Zhejiang the First Affiliated Hospital of Zhejiang Chinese Medical University

OBJECTIVE: To investigate the mechanisms of the effect of actinidia chinensis polysaccharide(ACPS) on the invasion and metastasis of gastric cancer ***: BGC-823-Luc gastric cancer cells stably transfected with a luciferase gene were used to establish an insitutransplanted tumor mouse model. A live mouse imaging system was used to observe tumor growth, and hematoxylin and eosin staining was applied to analyze tissue histopathology. Transwell and scratch wound assays were performed to examine the invasive and migratory ability of BGC-823 cells. Immunofluorescence,confocal microscopy, immunohistochemistry, and Western blot assays were used to analyze the expressions of the nuclear transcription factor-κB(NF-κB)signaling pathway and epithelial-mesenchymal transition(EMT)-related ***: ACPS significantly inhibited the growth of subcutaneously transplanted BGC-823-Luc gastric cancer tumors in nude mice and reduced inflammatory cell infiltration in tumor tissues. ACPS inhibited Epidermal Growth Factor-induced invasion, migration, and morphological changes in the cytoskeleton of BGC-823cells. ACPS inhibited gastric cancer EMT and decreased the expression of matrix metallopeptidase 9, N-cadherin and p-NF-κB p65 in transplanted tumor tissues. ACPS inhibited the expression of matrix metalloproteinases and vascular adhesion factors in BGC-823 cells, promoted p65-NF-κB nuclear translocation, and regulated proteins associated with the NF-κB p65 ***: ACPS inhibited gastric cancer invasion and metastasis both in vivo and in vitro, which evidenced the inhibition of gastric cancer EMT via regulating the NF-κB inflammatory pathway.

关键词： actinidia chinensis polysaccharide NF-kappa B epithelial-mesenchymal transition invasion neoplasm metastasis signal transduction stomach neoplasms

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