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ABCG5和ABCG8与胆固醇结石形成的关系

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中华肝胆外科杂志 2005年第9期11卷 583-585页

作者：沈振斌秦新裕童赛雄锁涛复旦大学附属中山医院上海市200032

目的探讨ABCG5和ABCG8与结石形成的关系。方法测定结石组病人结石胆固醇含量,确定为胆固醇结石。比较禁食情况下胆固醇结石病人和胃癌病人中血脂、脂蛋白的差异,采用实时PCR方法比较胆固醇结石病人与胃癌病人ABCG5和ABCG8mRNA的差异。... 详细信息

目的探讨ABCG5和ABCG8与结石形成的关系。方法测定结石组病人结石胆固醇含量,确定为胆固醇结石。比较禁食情况下胆固醇结石病人和胃癌病人中血脂、脂蛋白的差异,采用实时PCR方法比较胆固醇结石病人与胃癌病人ABCG5和ABCG8mRNA的差异。结果两组病例血脂、脂蛋白比较无明显差异。胆固醇结石组ABCG5/beta-actin和ABCG8/beta-actin均高于胃癌组(为17.6%±9.8%vs13.5%±6.2%,P<0.01;18.9%±7.1%vs16.5%±4.2%,P<0.01),说明胆固醇结石病人在基础情况下ABCG5和ABCG8有较高的转录水平。结论本研究提示胆固醇结石的形成与肝脏ABCG5和ABCG8高表达,向胆汁中转运较多的胆固醇有关。

关键词：胆结石结石成因 ABCG5 ABCG8 胆固醇结石形成胃癌病人胆固醇含量 PCR方法 actin mRNA

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Effects of early maternal separation on CRMP2 and microtubule dynamics in the hippocampus of young rats

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China Medical Abstracts (Internal Medicine) 2020年第4期37卷 235-235页

作者：魏艳艳 Renmin Hosp Wuhan Univ

Objective To investigate the effects of different degrees of maternal separation(MS) stress on hippocampus CRMP2,P-CRMP2 expression and microtubule dynamics in young male *** Thirty-six newborn male rats were randomly divided into three groups:maternal separation 360 min group (MS360 group),maternal separation 15 min group (MS15 group) and normal control group (NC group).

关键词： actin Effects of early maternal separation on CRMP2 and microtubule dynamics in the hippocampus of young rats

Vacuole import and degradation pathway: Insights into a specialized autophagy pathway

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World Journal of Biological Chemistry 2011年第11期2卷 239-245页

作者： Abbas A Alibhoy Hui-Ling Chiang Department of Cellular and Molecular Physiology Penn State University College of Medicine

Glucose deprivation induces the synthesis of pivotagluconeogenic enzymes such as fructose-1,6-bisphos-phatase, malate dehydrogenase, phosphoenolpyruvatecarboxykinase and isocitrate lyase in Saccharomycescerevisiae. However, following glucose replenishment,these gluconeogenic enzymes are inactivated and de-graded. Studies have characterized the mechanismsby which these enzymes are inactivated in response toglucose. The site of degradation of these proteins hasalso been ascertained to be dependent on the dura-tion of starvation. Glucose replenishment of short-termstarved cells results in these proteins being degradedin the proteasome. In contrast, addition of glucose tocells starved for a prolonged period results in theseproteins being degraded in the vacuole. In the vacuoledependent pathway, these proteins are sequestered inspecialized vesicles termed vacuole import and degra-dation (Vid). These vesicles converge with the endo-cytic pathway and deliver their cargo to the vacuolefor degradation. Recent studies have identified thatinternalization, as mediated by actin polymerization, isessential for delivery of cargo proteins to the vacuolefor degradation. In addition, components of the targetof rapamycin complex 1 interact with cargo proteins during glucose starvation. Furthermore, Tor1p dissoci-ates from cargo proteins following glucose replenish-ment. Future studies will be needed to elaborate on the importance of internalization at the plasma membrane and the subsequent import of cargo proteins into Vid vesicles in the vacuole dependent degradation pathway.

关键词： Vacuole import and degradation Fructose-1,6-bisphosphatase Vacuole Proteasome Autophagy Target of rapamycin complex 1 actin polymerization Endocytosis

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不一样的浪漫--《尽善尽美》观感

海外英语 2005年第7期 74-页

作者：黄英霞

　　The story is quite unbelievable,but who can stand up and say it's not convincing?Since we can't deny love can change and make everything better,by the way,the actors are really into their roles!……

关键词： and abl 观感 excel look actin well think will cast

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肝血管平滑肌脂肪瘤21例临床病理观察

诊断病理学杂志 2001年第5期8卷 267-269页

作者：纪小龙纪元钟定荣申明识解放军总医院病理科北京100853 上海医科大学附属中山医院

目的　研究肝血管平滑肌脂肪瘤 (HAML)的形态学特点。方法　收集 2 1例HAML的临床相关资料 ;采用HE染色、特殊染色、免疫组化、电镜等方法进行研究。结果　HAML患者的症状、体征及影像学均有其特征 ,病理形态学上均显示有血管周上皮样细... 详细信息

目的　研究肝血管平滑肌脂肪瘤 (HAML)的形态学特点。方法　收集 2 1例HAML的临床相关资料 ;采用HE染色、特殊染色、免疫组化、电镜等方法进行研究。结果　HAML患者的症状、体征及影像学均有其特征 ,病理形态学上均显示有血管周上皮样细胞 ,血管有厚壁和薄壁两种 ,上皮样细胞分为 4种形态 ,形态与免疫表型有一定的相关性 ,部分上皮样细胞胞浆PAS染色阳性且抗淀粉酶消化 ,电镜下可见类似前黑色素小体的特殊晶体样结构及密体。结论　HAML是一种好发于中青年女性的良性肿瘤 ,其特点为actin、HMB45 (+)。HAML因其特殊形态。

关键词：肝肿瘤血管平滑肌脂肪瘤 actin HMB45 临床病理

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