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Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia

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Chinese Medical Journal 2013年第3期126卷 526-531页

作者： WANG Zhi-ren TAN Yun-long YANG Fu-de ZHANG Wu-fang ZOU Yi-zhuang TAN Shu-ping SONG Chong-sheng LI Ying-li ZHANG Wei-hua ZHOU Dong-feng Institute of Mental Health Peking University Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing 100191 China Beijing Hui-Long-Guan Hospital Beijing 100096 China

Background Patients with schizophrenia have prominent abnormality in information processing that can be observed by measures of prepulse inhibition （PPI） of acoustic startle reflex and PPI deficits have been considered as a candidate endophenotypic marker of schizophrenia. However, there has been little information on PPI and related measures in Chinese patients with schizophrenia. The research was to explore the deficits of acoustic startle reflex that might exist in Chinese patients with schizophrenia. Methods startle response to acoustic stimuli, habituation, and PPI were examined in 31 Chinese patients with first-episode, medication-naive schizophrenia and 30 age-and sex-matched healthy Chinese controls. At the same day of startle testing, psychopathological symptoms of the patients were assessed with the Positive and Negative Syndrome Scale （PANSS）. Results Compared with healthy controls, patients exhibited the significant reduction in startle response and PPI deficits at 60 milliseconds （ms） intervals （PP160, P 〈0.05） but not at 30 or 120 ms intervals. Furthermore, there was a relatively strong correlation between PPI60 （P 〈0.05） and scores of positive scale of PANSS in patients with schizophrenia. Conclusion Our findings confirmed impaired PPI in Chinese patients with schizophrenia and suggested that a relationship between sensorimotor gating deficits and clinical symptoms of patients with schizophrenia might exist.

关键词： acoustic startle prepulse inhibition schizophrenia

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ANIMAL BEHAVIORAL MODELS OF TINNITUS

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Journal of Otology 2014年第2期9卷 58-63页

作者： ZHANG Chao WANG Qiuju SUN Wei Department of Otolaryngology Chinese PLA General Hospital Center for Hearing & Deafness Department of Communicative Dis-orders and SciencesState University of New York at Buffalo 3435 Main StreetBuffaloNY 14214

The pathophysiology of tinnitus is poorly understood and treatments are often unsuccessful. A number of animal models have been developed in order to gain a better understanding of tinnitus. A great deal has been learned from these models re- garding the electrophysiological and neuroanatomical correlates of tinnitus following exposure to noise or ototoxic drugs. Re- liable behavioral data is important for determining whether such electrophysiological or neuroanatomical changes are indeed related to tinnitus. Of the many documented tinnitus animal behavioral paradigms, the acoustic startle reflex had been pro- posed as a simple method to identify the presence or absence of tinnitus. Several behavioral models based on conditioned re- sponse suppression paradigms have also been developed. In addition to determining the presence or absence of tinnitus, some of the behavioral paradigms have provided signs of the onset, frequency, and intensity of tinnitus in animals. Although none of these behavioral models have been proved to be a perfect model, these studies provide useful information on understanding the neural mechanisms underlying tinnitus.

关键词： Tinnitus Behavioral model acoustic startle Noise exposure Salicylate

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